Home Ubiquitin E3 Ligase inhibitor Smurf1-IN-A01 For research use only.

Smurf1-IN-A01

Synonyms: A01, SMURF1 inhibitor A01

Smurf1-IN-A01 can inhibit Smurf1-mediated Smad1/5 degradation and accelerate BMP-2 signal responsiveness with a Kd of 3.664 nM.

Smurf1-IN-A01 Chemical Structure

Smurf1-IN-A01 Chemical Structure

CAS: 1007647-73-5

Purity & Quality Control

Batch: S034501 DMSO] 100 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.95%
99.95

Smurf1-IN-A01 Related Products

Signaling Pathway

E3 Ligase Signaling Pathways

E3 Ligase Signaling Pathway

Choose Selective E3 Ligase Inhibitors

Biological Activity

Description Smurf1-IN-A01 can inhibit Smurf1-mediated Smad1/5 degradation and accelerate BMP-2 signal responsiveness with a Kd of 3.664 nM.
Targets
Smurf1 [1]
3.664 nM(Kd)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06193538 Recruiting
Advanced Glioblastoma Patients
First Affiliated Hospital of Wannan Medical College
 September 14 2023 Phase 1
NCT06048536 Recruiting
Contraception
Viatris Inc.
 March 7 2023 Phase 2
NCT05139121 Enrolling by invitation
Contraception
Mylan Technologies Inc.|Mylan Inc.|Viatris Inc.
 October 26 2021 Phase 3
NCT04012242 Recruiting
Nonalcoholic Steatohepatitis|Ultrasound|Elastography
Tokyo Medical University
 June 15 2019 --
NCT01357993 Completed
Attention-Deficit / Hyperactivity Disorder
Janssen Pharmaceutical K.K.
 May 2011 Phase 3

Chemical Information & Solubility

Molecular Weight 512.93 Formula

C22H20ClF3N4O3S
CAS No. 1007647-73-5 SDF --
Smiles CC1=CC=NN1C2=CC=C(C=C2)C(=O)N3CCN(CC3)S(=O)(=O)C4=CC(=C(C=C4)Cl)C(F)(F)F
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (194.95 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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