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Promethazine HCl

Name: Promethazine HCl
Brand: Selleck Chemicals
SKU: S4293
Rating: 5 (3 reviews)

Catalog No.S4293 Purity: 99.84%

Promethazine HCl is a potent histamine H₁ receptor antagonist, used as a sedative and antiallergic medication.

Promethazine HCl Chemical Structure

CAS: 58-33-3

Selleck's Promethazine HCl has been cited by 3 publications

Purity & Quality Control

Batch: Purity: 99.84%

99.84

Promethazine HCl Related Products

Related Targets	H1 receptor H2 receptor H3 receptor H4 receptor	Click to Expand
Related Compound Libraries	FDA-approved Drug Library Natural Product Library Neuronal Signaling Compound Library CNS-Penetrant Compound Library Anti-alzheimer Disease Compound Library	Click to Expand

Signaling Pathway

Histamine Receptor Signaling Pathway

Choose Selective Histamine Receptor Inhibitors

Biological Activity

Description	Promethazine HCl is a potent histamine H₁ receptor antagonist, used as a sedative and antiallergic medication.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05759481	Not yet recruiting	Post-operative Nausea and Vomiting	Milton S. Hershey Medical Center	January 2024	Phase 2
NCT04805073	Recruiting	Pruritus\|Pregnancy Related	University of Florida	August 9 2021	Phase 4
NCT03539562	Completed	Labor Pain\|Early Labor	University of California San Francisco	September 27 2017	--
NCT02465866	Completed	Healthy	Charleston Laboratories Inc	November 2014	Phase 1
NCT01644838	Completed	Labor Pain	Mashhad University of Medical Sciences	August 2010	Phase 2\|Phase 3

Chemical Information & Solubility

Molecular Weight	320.88	Formula	C₁₇H₂₁ClN₂S
CAS No.	58-33-3	SDF	Download Promethazine HCl SDF
Smiles	CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C.Cl
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 64 mg/mL ( (199.45 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 64 mg/mL

Ethanol : 34 mg/mL

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
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