Promethazine HCl

Catalog No.S4293

Promethazine HCl is a potent histamine H1 receptor antagonist, used as a sedative and antiallergic medication.

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Promethazine HCl Chemical Structure

Promethazine HCl Chemical Structure
Molecular Weight: 320.88

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

Promethazine HCl is available in the following compound libraries:

Product Information

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Product Description

Biological Activity

Description Promethazine HCl is a potent histamine H1 receptor antagonist, used as a sedative and antiallergic medication.
In vitro
In vivo

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)
Body Surface Area (m2)0.0070.0250.
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)


Clinical Trial Information( data from, updated on 2016-07-30)

NCT Number Recruitment Conditions Sponsor
Start Date Phases
NCT02625181 Recruiting Postoperative Nausea and Vomiting Vanderbilt University|University of Washington July 2016 --
NCT02765256 Not yet recruiting Crohns Disease University of Pennsylvania|Childrens Hospital of Philadel  ...more University of Pennsylvania|Childrens Hospital of Philadelphia|Crohns and Colitis Foundation June 2016 Phase 2
NCT02374567 Recruiting Dementia|Depression|Schizophrenia|Psychosomatic Disorders|Anxiety Disorders Hannover Medical School January 2015 Phase 3
NCT02130622 Recruiting Diabetic Gastroparesis Dartmouth-Hitchcock Medical Center|American College of Ga  ...more Dartmouth-Hitchcock Medical Center|American College of Gastroenterology July 2014 Phase 2
NCT02136420 Active, not recruiting Vestibular [email protected]|National Space Biomedical  ...more [email protected]|National Space Biomedical Research Institute|Massachusetts Institute of Technology|Massachusetts Eye and Ear Infirmary June 2014 Phase 4

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Chemical Information

Download Promethazine HCl SDF
Molecular Weight (MW) 320.88


CAS No. 58-33-3
Storage 3 years -20℃powder
2 years -80℃in solvent
Synonyms N/A
Solubility (25°C) * In vitro DMSO 64 mg/mL (199.45 mM)
Water 64 mg/mL (199.45 mM)
Ethanol 34 mg/mL (105.95 mM)
In vivo
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 10-[2-(dimethylamino)propyl]phenothiazine hydrochloride

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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