Promethazine HCl

Catalog No.S4293

Promethazine HCl Chemical Structure

Molecular Weight(MW): 320.88

Promethazine HCl is a potent histamine H1 receptor antagonist, used as a sedative and antiallergic medication.

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USD 97 In stock
USD 197 In stock

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Purity & Quality Control

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Promethazine HCl is a potent histamine H1 receptor antagonist, used as a sedative and antiallergic medication.

Protocol

References

Solubility (25°C)

In vitro DMSO 64 mg/mL (199.45 mM)
Water 64 mg/mL (199.45 mM)
Ethanol 34 mg/mL (105.95 mM)
In vivo

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 320.88
Formula

C17H21ClN2S

CAS No. 58-33-3
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02625181 Recruiting Postoperative Nausea and Vomiting Vanderbilt University|University of Washington July 2016 --
NCT02765256 Not yet recruiting Crohns Disease University of Pennsylvania|Childrens Hospital of Philadelphia|Crohns and Colitis Foundation June 2016 Phase 2
NCT02374567 Recruiting Dementia|Depression|Schizophrenia|Psychosomatic Disorders|Anxiety Disorders Hannover Medical School January 2015 Phase 3
NCT02130622 Recruiting Diabetic Gastroparesis Dartmouth-Hitchcock Medical Center|American College of Gastroenterology July 2014 Phase 2
NCT02136420 Active, not recruiting Vestibular [email protected]|National Space Biomedical Research Institute|Massachusetts Institute of Technology|Massachusetts Eye and Ear Infirmary June 2014 Phase 4
NCT01827293 Completed Peripheral Vertigo. Shahid Beheshti University of Medical Sciences April 2013 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Histamine Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID