PF-562271

Catalog No.S2890

PF-562271 Chemical Structure

Molecular Weight(MW): 507.49

PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.

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In DMSO USD 350 In stock
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USD 270 In stock
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4 Customer Reviews

  • (F,G) The migration and invasion ability of 5637 and T24 cells transfected with PF-562271 and WT-METTL13 was examined. The number of cells was quantified and is shown in a column graph.

    Sci Rep, 2016, 6:19261. PF-562271 purchased from Selleck.

    D-F. T47D cells plated as in A were treated with vehicle (−) or the FAK Y397 inhibitor, PF-562271 (+), for 1 h prior to ± PRL (4 nM) for 15 min (representative immunoblots).

    Oncotarget, 2016, 7(30):48093-48106. PF-562271 purchased from Selleck.

  • OVISE cells were incubated for 24 hr at the indicated concentrations of the FAK inhibitors. Immunoblots were performed to assess inhibition of auto-phosphorylation by the FAK inhibitors.

    PLoS One 2014 9(2), e88587. PF-562271 purchased from Selleck.

    VEGF and P450 enzyme production in response to FAK or Src inhibitors. MCF10A cells were cultured in LD collagen gels ?vehicle control (V), 10 uM PF-562271 FAK ATP inhibitor (PF) or Src inhibitor PP2 for 24 h. Cells were also lysed and examined for CYP1A1 or CYP4B1 by immunoblot (B and C) and densitometry (D and E). VEGF data are displayed as the mean normalized to the vehicle control, N = 6, 盨EM, *p < 0.003 vs control (A). P450 data are displayed as the mean relative to GAPDH and normalized to the control. N > 4, ±SEM, *p < 0.05 vs respective control (D and E).

    Environ Toxicol Pharmacol 2014 39(1), 114-124. PF-562271 purchased from Selleck.

Purity & Quality Control

Choose Selective FAK Inhibitors

Biological Activity

Description PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.
Targets
FAK [1]
(Cell-free assay)
PYK2 [1]
(Cell-free assay)
CDK2/CyclinE [1]
(Cell-free assay)
CDK3/CyclinE [1]
(Cell-free assay)
CDK1/CyclinB [1]
(Cell-free assay)
1.5 nM 13 nM 30 nM 47 nM 58 nM
In vitro

PF-562271 binds in the ATP-binding cleft of FAK, forming two of the three “canonical” H-bonds between the inhibitor and main-chain atoms in the kinase hinge region. PF-562271 is potent in an inducible cell-based assay measuring phospho-FAK with IC50 of 5 nM. PF-562271 (3.3 μM) results in G1 arrest of PC3-M cells. [1] PF-562271 (1 nM) blocks bFGF-stimulated blood vessel angiogenesis as performed in chicken chorioallantoic membrane assays. PF-262271 potently blocks blood vessel sprouting without detectable changes in vascular leakage. [2] PF-562271 (250 nM) results in complete inhibition of collective A431 cell invasion into collagen gels. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MV-4-11 M1yzfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3[xNWlEPTB;MD6yO|Y3KM7:TR?= M4LUT3NCVkeHUh?=
SW982 M2DwSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTBwM{K4NkDPxE1? NH7xVohUSU6JRWK=
KM12 M3jieWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DjV2lEPTB;MD6zPFU2PyEQvF2= M{juZnNCVkeHUh?=
COLO-205 NVzpXXU1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTWfFBKSzVyPUCuOFg3PThizszN MomzV2FPT0WU
COLO-829 NVLFZmV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TOXGlEPTB;MD63OVE4PiEQvF2= MYrTRW5ITVJ?
MG-63 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn[wTWM2OD1yLkiwOlM4KM7:TR?= MmLuV2FPT0WU
IGROV-1 MnviS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPCTWM2OD1yLkixNFM5KM7:TR?= MXjTRW5ITVJ?
NCI-H650 M4G3Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwOEOxOVQh|ryP NFTO[4FUSU6JRWK=
RT-112 NGjORZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTBwOUi0OkDPxE1? NFrpTIRUSU6JRWK=
BCPAP MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTFwMEGyPFgh|ryP NUfNWm12W0GQR1XS
ALL-PO NIPKN|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVe3XmV4UUN3ME2xMlAyPTh2IN88US=> MWLTRW5ITVJ?
KYSE-270 NGHmXnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jkXmlEPTB;MT6wOFcyPCEQvF2= MYnTRW5ITVJ?
8305C MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XsVWlEPTB;MT6wPVkxPCEQvF2= MnrsV2FPT0WU
NCI-H810 NUHwRWt4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzVRXp5UUN3ME2xMlExPzd4IN88US=> NFjBfWZUSU6JRWK=
CAL-33 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrKTWM2OD1zLkGyPVM5KM7:TR?= MUfTRW5ITVJ?
AN3-CA NX;OXHhoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH[0RplKSzVyPUGuNlE5PjdizszN NEj3V2NUSU6JRWK=
NKM-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTFwMke1NFYh|ryP MorzV2FPT0WU
BPH-1 NUHQNXRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTUU3VKSzVyPUGuNlg4PjZizszN NIPsdHZUSU6JRWK=
MES-SA NUPVOHZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTFwM{C2PFIh|ryP NX\Ge5RQW0GQR1XS
CAL-62 MmftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTnTWM2OD1zLkOxPVA6KM7:TR?= MXPTRW5ITVJ?
Detroit562 NFXtW2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfiTWM2OD1zLkO1NlIzKM7:TR?= MlH4V2FPT0WU
KYSE-150 NVjBRm9KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTFwM{WyN|Yh|ryP MVHTRW5ITVJ?
SK-UT-1 NI\tcGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHNU45KSzVyPUGuOFQ3PDdizszN NHLNfZdUSU6JRWK=
HUTU-80 MnnDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTFwNES4PFYh|ryP NIrIe2hUSU6JRWK=
SIG-M5 Moe2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPqdVdNUUN3ME2xMlQ5Ozh5IN88US=> M1jhfXNCVkeHUh?=
AGS M2DncWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TQZ2lEPTB;MT61NlEzPCEQvF2= NFTMdI5USU6JRWK=
ST486 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jMTGlEPTB;MT61N|I4QCEQvF2= M{jRUHNCVkeHUh?=
HSC-2 MoTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDvRnoxUUN3ME2xMlU{QTVizszN MnvPV2FPT0WU
LCLC-103H MnvVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfTTWM2OD1zLkW1PFE5KM7:TR?= MWnTRW5ITVJ?
BC-1 MnfIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PVcmlEPTB;MT62NVY3PCEQvF2= M3PsdHNCVkeHUh?=
CGTH-W-1 NHyzTlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTqTplIUUN3ME2xMlYyPjd7IN88US=> MnKyV2FPT0WU
MZ1-PC NUnFN5ZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTFwNkKzNVIh|ryP NYrLdpZNW0GQR1XS
SW1710 MknVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PPeWlEPTB;MT62NlYzQCEQvF2= NIna[HBUSU6JRWK=
EW-13 MmjLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDWeZVKSzVyPUGuOlM1PjZizszN MnvHV2FPT0WU
TE-11 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHDdJpKSzVyPUGuOlM2OjJizszN NEPpO25USU6JRWK=
BHY M2PWNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\kd2lEPTB;MT62OVY3OyEQvF2= NG[1e3BUSU6JRWK=
ML-2 NVm4fnFOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTFwNk[4NFIh|ryP MlnjV2FPT0WU
MEL-JUSO M2frfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4e2eWlEPTB;MT63Nlg6OSEQvF2= M3jNR3NCVkeHUh?=
U251 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\DTWM2OD1zLke0NFMyKM7:TR?= M3n4XXNCVkeHUh?=
MHH-ES-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTFwN{m1Olgh|ryP MoPRV2FPT0WU
CAL-85-1 M2\5fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MomxTWM2OD1zLkiwOFkh|ryP MWHTRW5ITVJ?
D-336MG NEnUUYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXueJRlUUN3ME2xMlg2PjF2IN88US=> MUDTRW5ITVJ?
VA-ES-BJ MmjLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvPOoZRUUN3ME2xMlkxOzF3IN88US=> NIjreXFUSU6JRWK=
MDA-MB-468 NFrJPZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{f0WmlEPTB;MT65NVI4OiEQvF2= M2HYXnNCVkeHUh?=
MEL-HO M3;T[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2C2[mlEPTB;MT65O|k6OyEQvF2= M4jvWXNCVkeHUh?=
SW954 NHPpNZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLLcIJ7UUN3ME2yMlAxOTVzIN88US=> NIT1RotUSU6JRWK=
LB831-BLC NVnOb3JqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXwc4xKSzVyPUKuNFA6QDhizszN MWTTRW5ITVJ?
EW-16 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTJwMEO5PFMh|ryP M33MTHNCVkeHUh?=
NCI-H460 NVfxSIJuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjHZmJrUUN3ME2yMlA1QDN7IN88US=> NX\FbFFFW0GQR1XS
CHP-212 NV;vOYxST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTJwMEm1N|kh|ryP NXHxNGZ6W0GQR1XS
MHH-NB-11 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTOTIdWUUN3ME2yMlEzQDF6IN88US=> MWHTRW5ITVJ?
DU-4475 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTJwMUS3OVkh|ryP M2r6R3NCVkeHUh?=
ABC-1 NF;IT2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TMfmlEPTB;Mj6yOVE6PiEQvF2= MV7TRW5ITVJ?
LOUCY NU\yUoM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\hTWM2OD1{LkK2NVI5KM7:TR?= NHP4SYZUSU6JRWK=
LC-2-ad MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnrUZhbUUN3ME2yMlI3QTZ4IN88US=> M1PMZXNCVkeHUh?=
ETK-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXvTWM2OD1{LkK4OFYh|ryP Mki5V2FPT0WU
KYSE-180 MnXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HLfmlEPTB;Mj6yPFg4PCEQvF2= NGrBWW9USU6JRWK=
HOP-92 NFzPb5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXMTWM2OD1{LkOwOlc{KM7:TR?= M2nqPHNCVkeHUh?=
RCC10RGB MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TrSmlEPTB;Mj6zNlUxPyEQvF2= MnvOV2FPT0WU
KASUMI-1 MlS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fHfWlEPTB;Mj6zNlg5KM7:TR?= M2jTWXNCVkeHUh?=
ACN MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTJwM{S3OFUh|ryP MYTTRW5ITVJ?
BxPC-3 M4TDe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDXTWM2OD1{LkO1OFM3KM7:TR?= MlnVV2FPT0WU
MONO-MAC-6 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLpTWM2OD1{LkSxNlQ5KM7:TR?= NHjt[o1USU6JRWK=
CAL-39 NXfGUlhST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTJwNEG2Nlgh|ryP M162UnNCVkeHUh?=
CMK NFr0OpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLCTWM2OD1{LkSxO|k2KM7:TR?= MmXNV2FPT0WU
MFE-296 MlX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTJwNEe3PVIh|ryP M1zUZnNCVkeHUh?=
DU-145 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnJXnlKSzVyPUKuOFkyOThizszN MofLV2FPT0WU
MDA-MB-231 NXzUZWdVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17rfmlEPTB;Mj60PVU4OiEQvF2= NF7YUHlUSU6JRWK=
EFO-27 MkO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XDNmlEPTB;Mj61NVg5QCEQvF2= MUHTRW5ITVJ?
SNU-387 NHzNc2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTJwNUK4NkDPxE1? NGjSRVdUSU6JRWK=
KYSE-410 NWexZ5pwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHBXoxKSzVyPUKuOVY2OTdizszN NUPUWVUyW0GQR1XS
NCCIT M1rlSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTJwNUeyOEDPxE1? NWTtNINiW0GQR1XS
LXF-289 NXXSbG1CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTJwNUiyO|Mh|ryP NWG0Z2I5W0GQR1XS
HMV-II NFHMepJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;qXpRKSzVyPUKuOVg6QTdizszN NX70Z4dbW0GQR1XS
MOLT-4 NWPIe2JQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIX5dXRKSzVyPUKuOlA4OTJizszN MmrIV2FPT0WU
KOSC-2 MnnqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;RO2VoUUN3ME2yMlY{QDd7IN88US=> NHe1TmVUSU6JRWK=
TUR MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHYdHdKSzVyPUKuOlU{PjlizszN NVX2XZNiW0GQR1XS
NCI-H2087 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DxUWlEPTB;Mj63NVY1PiEQvF2= M{Swd3NCVkeHUh?=
SCC-15 M{[5PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojwTWM2OD1{Lke1NlUzKM7:TR?= Mn34V2FPT0WU
HSC-4 MnW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPkWYVKSzVyPUKuO|g{QDlizszN MoPCV2FPT0WU
G-402 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzTVZZKSzVyPUKuPFE1PDdizszN MlvFV2FPT0WU
GP5d NHrV[otIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHKOVdKSzVyPUKuPFM5OjdizszN M3ewcXNCVkeHUh?=
IGR-1 NH7MbmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLkTWM2OD1{LkizPVg4KM7:TR?= M1vIT3NCVkeHUh?=
SK-PN-DW NFnmNZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF30[WNKSzVyPUKuPFYzODRizszN M4TuSHNCVkeHUh?=
OPM-2 M4T0OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTJwOEm5O|gh|ryP M1rIfnNCVkeHUh?=
5637 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTJwOUK0N|kh|ryP M{Puc3NCVkeHUh?=
NCI-H2030 NFiwU25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\xVFNKSzVyPUKuPVgxOjlizszN NV3ycIp3W0GQR1XS
SK-LU-1 NGG0RphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHmye3FKSzVyPUKuPVg{OzRizszN NYf1TWdXW0GQR1XS
EW-18 M4TZPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvTNYdKSzVyPUOuNFU{OiEQvF2= NEHlZZlUSU6JRWK=
786-0 M2[yfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vIUmlEPTB;Mz6wOVc5PCEQvF2= MWLTRW5ITVJ?
NCI-H1963 MoPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTNwMEi4NlUh|ryP NHXnXIxUSU6JRWK=
A2780 M3HmNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTNwMUCzOFEh|ryP NH\SXWNUSU6JRWK=
NCI-H526 MnnMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvPWI9EUUN3ME2zMlE{QTZzIN88US=> NGHVeY9USU6JRWK=
BHT-101 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7weI9KSzVyPUOuNVU4QThizszN MV;TRW5ITVJ?
RPMI-7951 NUXqOJhtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVG3d29QUUN3ME2zMlIxOTN5IN88US=> NIK1WINUSU6JRWK=
HL-60 NGX1SZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjxbVltUUN3ME2zMlIyOTRizszN MnWxV2FPT0WU
CTV-1 NEXtSohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfCZ4Z{UUN3ME2zMlI2Ozd5IN88US=> NWS3eYttW0GQR1XS
IST-SL1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjrZ|FKSzVyPUOuNlk1PjVizszN MYLTRW5ITVJ?
G-401 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjabmY6UUN3ME2zMlI6QDB6IN88US=> NHizSZJUSU6JRWK=
OVCAR-5 MkHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3zTmRKSzVyPUOuN|Y{PTJizszN NWXjU4dkW0GQR1XS
EW-1 M{TNR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jwfmlEPTB;Mz60NFU1PCEQvF2= MoPYV2FPT0WU
H4 NGnle5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1Gz[2lEPTB;Mz60O|U3QSEQvF2= NEfKU|lUSU6JRWK=
EM-2 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\zTWM2OD1|LkS4Olc1KM7:TR?= M1nGW3NCVkeHUh?=
RS4-11 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2iwVWlEPTB;Mz60PFcyPSEQvF2= Mk\kV2FPT0WU
NOMO-1 M{DFWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HvZ2lEPTB;Mz60PVIxPCEQvF2= NYLvb5BtW0GQR1XS
HCT-116 MnvCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTNwNUC3NVEh|ryP MlLmV2FPT0WU
CAL-120 NUT1S4ZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDHfIZKSzVyPUOuOVc{PSEQvF2= M1:5N3NCVkeHUh?=
CAL-51 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjFTWM2OD1|LkW3OlEzKM7:TR?= MVzTRW5ITVJ?
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NCI-H2081 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTNwNkWyPFgh|ryP NXHUS5dtW0GQR1XS
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CAS-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTFyLkS2NFgh|ryP NEey[ZVUSU6JRWK=
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JiyoyeP-2003 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX6wPXp6UUN3ME2xNU4xQDl{IN88US=> M{\OSHNCVkeHUh?=
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HLE NFS4[HNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTFzLkKxNVkh|ryP M3H2O3NCVkeHUh?=
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L-540 NV\NOZZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DHOmlEPTB;MUGuPFk6KM7:TR?= NGnHe41USU6JRWK=
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CAL-27 M{S3SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;mW2lEPTB;MUKuNVM3QSEQvF2= M4nWPHNCVkeHUh?=
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KINGS-1 M4LE[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPXTWM2OD1zMj6zOFIyKM7:TR?= M3rafXNCVkeHUh?=
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HAL-01 M3v2dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPFc|lKSzVyPUGyMlYyPzRizszN NHruT3dUSU6JRWK=
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HT M3Hzd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13nUmlEPTB;MUKuPVQ{PyEQvF2= NUfES4c3W0GQR1XS
OE33 NIDIZ2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3WSJVqUUN3ME2xNk46PDV4IN88US=> NXrMPIJxW0GQR1XS
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LB2241-RCC NVjUNZd5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PFSmlEPTB;MUOuNVQ3QSEQvF2= NETie3ZUSU6JRWK=
CCF-STTG1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XlZ2lEPTB;MUOuOFA{QSEQvF2= M17xV3NCVkeHUh?=
RPMI-8402 NHvhbWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTF|LkWwN|Eh|ryP NV3tWmRyW0GQR1XS
DEL M33uc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonRTWM2OD1zMz61OVA{KM7:TR?= MnL1V2FPT0WU
NB5 NWPhWG9UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTF|LkW1NFMh|ryP NV;Wd3lWW0GQR1XS
NUGC-3 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHzTWM2OD1zMz63OFU{KM7:TR?= MUjTRW5ITVJ?
CAL-72 NVXVbXZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTF2LkG5NFYh|ryP NWXHWYlKW0GQR1XS
VMRC-RCZ NEX0[FBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;wSGxKSzVyPUG0MlI{PiEQvF2= NH\sfpNUSU6JRWK=
YAPC NWnPZYVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV:3W2xEUUN3ME2xOE4zPDB5IN88US=> MVTTRW5ITVJ?
ES5 Ml\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LZdGlEPTB;MUSuNlU6QSEQvF2= NFy2eZFUSU6JRWK=
CAL-12T MoruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\vWYlKSzVyPUG0MlQ{OzZizszN NGrvWnRUSU6JRWK=
GAMG MljYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTF2LkW1O|ch|ryP NHexeHZUSU6JRWK=
BT-20 M4rKU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrJUG5RUUN3ME2xOE46Ozh2IN88US=> NIfVXHFUSU6JRWK=
KALS-1 NGrt[nZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTF3LkCxOVgh|ryP NIPCXJFUSU6JRWK=
LS-123 NWWxWGJFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTF3LkCxOlUh|ryP NX3tTIxGW0GQR1XS
LK-2 M2j0O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjIbWJKSzVyPUG1MlA5PjJizszN MnrsV2FPT0WU
NCI-H1770 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTJTWM2OD1zNT6yPFY5KM7:TR?= MWXTRW5ITVJ?
MIA-PaCa-2 MnGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLwTWM2OD1zNT60NVY{KM7:TR?= MXnTRW5ITVJ?
DB MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmexTWM2OD1zNT62PVQyKM7:TR?= NHrmbXVUSU6JRWK=
Becker NUDMbI5{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTF3Lki5NlYh|ryP NEG1T5RUSU6JRWK=
HT-144 NGTKUHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\l[WlEPTB;MUWuPVQ6PyEQvF2= M{Xj[3NCVkeHUh?=
NCI-H2405 MnWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHr0cHFKSzVyPUG2MlIzOThizszN M1HIU3NCVkeHUh?=
TK10 NIXNe4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTF4LkO3OFIh|ryP MmHwV2FPT0WU
THP-1 Mkn2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTF4LkS2OlUh|ryP M{LObHNCVkeHUh?=
LB373-MEL-D M2PxW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmr1TWM2OD1zNj62NVM5KM7:TR?= Ml;IV2FPT0WU
SJSA-1 NYL1eZM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXrOmpnUUN3ME2xOk46OjF7IN88US=> MmLnV2FPT0WU
EB2 M1jieGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3P3Z2lEPTB;MUeuO|QzPiEQvF2= M{LqdHNCVkeHUh?=
MN-60 NHS2OlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPvTWM2OD1zNz63PVM3KM7:TR?= NYq0UJB{W0GQR1XS
A253 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEm5fZJKSzVyPUG3MlgzPSEQvF2= MVjTRW5ITVJ?
CESS MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4ryUWlEPTB;MUeuPVMzPiEQvF2= MVzTRW5ITVJ?
EW-11 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTF5Lkm5OVgh|ryP M3zIe3NCVkeHUh?=
TE-8 M3Ty[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTF6LkC2Olkh|ryP MWfTRW5ITVJ?
UACC-257 NVHMW|UxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEj6c3JKSzVyPUG4MlIxPjJizszN MoThV2FPT0WU
NCI-H226 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmH3TWM2OD1zOD64Nlk6KM7:TR?= MnzLV2FPT0WU
NCI-H748 NHrCcIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUOz[JMyUUN3ME2xPE45PTh3IN88US=> NYL3OIR6W0GQR1XS
NCI-H1299 NXf4b2lGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXJW3FUUUN3ME2xPE45QTF6IN88US=> NYe5OYtsW0GQR1XS
IST-MEL1 MknsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVW1PGlyUUN3ME2xPU4yPzV2IN88US=> MmTVV2FPT0WU
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PF-382 NXLzbmltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjITWM2OD12MD63OFg4KM7:TR?= NUTCZ5pyW0GQR1XS
OAW-42 MlvpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTR{LkK5OFIh|ryP M4jWOXNCVkeHUh?=
LB996-RCC NVvub4h4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILEUYNKSzVyPUSyMlgxODhizszN MVPTRW5ITVJ?
SAS MluyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFqzTGRKSzVyPUSzMlQzQDhizszN NULWW|NQW0GQR1XS
MRK-nu-1 NF7aNJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXMTWM2OD12ND63OFE1KM7:TR?= M2DGenNCVkeHUh?=
EoL-1-cell NXj3eo1RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTR2LkmxN|Yh|ryP NV;CUHY3W0GQR1XS
NCI-H2342 NF7FV4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHe4OFlKSzVyPUS1MlEyOTdizszN MYHTRW5ITVJ?
NCI-H1703 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfMR4drUUN3ME20Ok4xPTl{IN88US=> MmCyV2FPT0WU
NCI-H187 NU[xUmlxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTR4LkG4Olkh|ryP NE\iWGJUSU6JRWK=
CP66-MEL Mn;tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXu4OXZZUUN3ME20Ok4zPzh7IN88US=> MULTRW5ITVJ?
HCC1569 M4PJUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1W2fmlEPTB;NE[uOVkyPyEQvF2= NEfwN|VUSU6JRWK=
BL-70 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fmdWlEPTB;NE[uO|c{PyEQvF2= MYnTRW5ITVJ?
Saos-2 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfFNYpKSzVyPUS3MlMyOjNizszN NIL1R|lUSU6JRWK=
LC-1F MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjwUYpGUUN3ME20O{43OTB3IN88US=> MUfTRW5ITVJ?
KY821 M2rPPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXudJdKSzVyPUS3MlY1OzRizszN MV\TRW5ITVJ?
PSN1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTR6LkG0NFEh|ryP NWrCZ2toW0GQR1XS
RT4 MorWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PGXWlEPTB;NEiuPFM4PyEQvF2= NHmxPXlUSU6JRWK=
LS-1034 NF7RU4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjYfYVMUUN3ME20PE45QTV2IN88US=> MkXFV2FPT0WU
NCI-H1395 Mly5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWriXo5SUUN3ME20PU4xPDl{IN88US=> MnHiV2FPT0WU
EKVX MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;GTWM2OD12OT62O|MyKM7:TR?= NWfQUWtqW0GQR1XS
IST-MES1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTR7Lki5OFQh|ryP NHPUPY5USU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo PF-562271 (< 33 mg/kg p.o.) inhibits FAK phosphorylation in tumors in a dose- and time-dependent manner in U87MG-bearing mice. PF-562271 (50 mg/kg p.o. bid) results in 86% tumor growth inhibition in BxPc3 xenografts mice and 45% tumor growth inhibition in PC3-M xenografts mice. PF-562271 (25 mg/kg, bid) results in 2-fold greater apoptosis in treated tumors in mice bearing H125 lung xenografts. [1] PF-562271 (33 mg/kg, p.o.) inhibits extensive movement of the tumor cells over 24 hours in mice. PF-562271 (33 mg/kg, p.o.) results in altered E-cadherin dynamics in mice, which correlates with reduced E-cadherin–dependent collective cell movement. [3] PF-562271 (25 mg/kg, p.o. bid) results in 62% tumor growth inhibition in PC3M-luc-C6 subcutaneuous local implant xenograft mouse model. [4] PF-562,271 (5 mg/kg, oral) results in significant and similar increases in osteocalcin and cancellous bone parameters and a decrease in tumor growth and signs of bone healing in rats implanted with MDA-MB-231 cells in the tibia. [5]

Protocol

Animal Research:[1]
+ Expand
  • Animal Models: Athymic female mice bearing BxPc3 or PC3-M xenografts.
  • Formulation: 5% Gelucire
  • Dosages: 50 mg/kg
  • Administration: Oral gavage
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL warmed (197.04 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents individually and in order:
30% PEG400+0.5% Tween80+5% propylene glycol
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 507.49
Formula

C21H20F3N7O3S

CAS No. 717907-75-0
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    What’s the difference between S2890 and S2672?

  • Answer:

    S2890 is free base and S2672 is the besylate salt, S2672 has better solubility than S2890.

Related Antibodies

FAK Signaling Pathway Map

Related FAK Products

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID