Pembrolizumab

Catalog No.A2005 Synonyms: MK-3475, lambrolizumab For research use only. Not for use in humans.

Pembrolizumab Chemical Structure

Pembrolizumab is a potent, highly selective, fully humanized immunoglobulin (Ig) G4-kappa monoclonal antibody against PD-1 with potential immune checkpoint inhibitory and antineoplastic activities.

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Purity & Quality Control

Choose Selective PD-1/PD-L1 Inhibitors

Biological Activity

Description Pembrolizumab is a potent, highly selective, fully humanized immunoglobulin (Ig) G4-kappa monoclonal antibody against PD-1 with potential immune checkpoint inhibitory and antineoplastic activities.
Targets
PD-1 [1]
(Cell-free assay)
In vivo In addition to Melanoma and Lung carcinoma, pembrolizumab has also demonstrated efficacy in other advanced solid tumors and hematologic malignancies. Pembrolizumab had an acceptable side-effect profile and showed antitumor activity in patients with advanced non-small-cell lung cancer[2].

Protocol

Chemical Information

Storage Store at -20°C for 2 years. Avoid freeze-thaw cycles.
Synonyms MK-3475, lambrolizumab

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID