OAC1

Catalog No.S7217 Synonyms: BAS 00287861

OAC1 Chemical Structure

Molecular Weight(MW): 237.26

Purity & Quality Control

Biological Activity

Description OAC1 (Oct4-activating compound 1) can enhance the efficiency of reprogramming.
Targets
Oct4 [1]
In vitro

OAC1 at 1 μM enhances reprogramming efficiency by activating both Oct4 and Nanog promoter-driven luciferase reporter genes. Furthermore, OAC1 enhances the pluripotent stem cells (iPSC) reprogramming efficiency and accelerates the reprogramming process in the quartet reprogramming factors (Oct4, Sox2, c-Myc, and Klf4) treated mouse embryonic fibroblasts (MEFs). The iPSC colonies derived using OAC1 along with the quartet factors exhibits typical ESC morphology, gene-expression pattern, and developmental potential. OAC1 seems to enhance reprogramming efficiency via increasing transcription of the Oct4-Nanog-Sox2 triad and Tet1, a gene known to be involved in DNA demethylation. While it doesn’t inhibit the p53-p21 pathway or activate the Wnt-β-catenin signaling. OAC1 may be used to enhance the reprogramming of somatic cells to a pluripotent state. [1]

Protocol

Cell Research:[1]
+ Expand
  • Cell lines: Human ESCs transfected with human Oct4 and Nanog luciferase reporter genes
  • Concentrations: ~1 μM
  • Incubation Time: 24 h
  • Method: The Oct4-luc or Nanog-luc cells are treated with compound OAC1 at 1 μM concentration. Luciferase reporter assays are performed 24 h after OAC1 treatment.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 47 mg/mL (198.09 mM)
Ethanol 21 mg/mL (88.51 mM)
Water <1 mg/mL
In vivo

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 237.26
Formula

C14H11N3O

CAS No. 300586-90-7
Storage powder
in solvent
Synonyms BAS 00287861

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID