Catalog No.S2916

ML-161 is an allosteric inhibitor of PAR1 with IC50 of 0.26 μM.

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In DMSO USD 190 In stock
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ML161 Chemical Structure

ML161 Chemical Structure
Molecular Weight: 361.23

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

ML161 is available in the following compound libraries:

Product Information

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Product Description

Biological Activity

Description ML-161 is an allosteric inhibitor of PAR1 with IC50 of 0.26 μM.
Targets PAR1
IC50 0.26 μM [1]
In vitro ML-161 is an allosteric inhibitor of PAR1. ML-161 displays dose-dependent inhibition of thrombin-induced platelet activation, as measured by P-selectin expression. ML-161 displays selective inhibition of SFLLRN and thrombin-induced platelet aggregation, both of which operate via PAR1, and has no effect on AYPGKF, thromboxane, or ADP-induced platelet aggregation, which are all agonists at alternative platelet GPCRs. [1]
In vivo

Protocol(Only for Reference)

Kinase Assay: [2]

P-Selectin Expression Assay Blood from healthy donors who has not ingested aspirin in the 2 weeks prior to donation is collected by venipuncture into 0.4% sodium citrate. Citrate-anticoagulated blood is centrifuged at 200g for 20 minutes to prepare platelet-rich plasma. Washed platelets are subsequently prepared from platelet-rich plasma by centrifugation at 1,000g in the presence of 0.15 μM PGE1. For analysis of P-selectin expression, 20 μL washed platelets (0.5-1 × 108/mL) are incubated with the indicated agonists. Platelet activation is measured by P-selectin surface expression using PE-antihuman P-selectin and flow cytometry. Results are expressed as percent inhibition of P-selectin surface expression.


Chemical Information

Download ML161 SDF
Molecular Weight (MW) 361.23


CAS No. 423735-93-7
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Syonnyms N/A
Solubility (25°C) * In vitro DMSO 72 mg/mL (199 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name Benzamide, 2-bromo-N-[3-[(1-oxobutyl)amino]phenyl]-

Preparing Stock Solutions

Stock Solution (1ml DMSO) 1mM 10mM 20mM 30mM
Mass(mg) 0.36123 3.6123 7.2246 10.8369

Research Area

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