ML161

Catalog No.S2916

ML-161 is an allosteric inhibitor of PAR1 with IC50 of 0.26 μM.

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In DMSO USD 190 In stock
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ML161 Chemical Structure

ML161 Chemical Structure
Molecular Weight: 361.23

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

ML161 is available in the following compound libraries:

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Product Description

Biological Activity

Description ML-161 is an allosteric inhibitor of PAR1 with IC50 of 0.26 μM.
Targets PAR1
IC50 0.26 μM [1]
In vitro ML-161 is an allosteric inhibitor of PAR1. ML-161 displays dose-dependent inhibition of thrombin-induced platelet activation, as measured by P-selectin expression. ML-161 displays selective inhibition of SFLLRN and thrombin-induced platelet aggregation, both of which operate via PAR1, and has no effect on AYPGKF, thromboxane, or ADP-induced platelet aggregation, which are all agonists at alternative platelet GPCRs. [1]
In vivo
Features

Protocol(Only for Reference)

Kinase Assay: [2]

P-Selectin Expression Assay Blood from healthy donors who has not ingested aspirin in the 2 weeks prior to donation is collected by venipuncture into 0.4% sodium citrate. Citrate-anticoagulated blood is centrifuged at 200g for 20 minutes to prepare platelet-rich plasma. Washed platelets are subsequently prepared from platelet-rich plasma by centrifugation at 1,000g in the presence of 0.15 μM PGE1. For analysis of P-selectin expression, 20 μL washed platelets (0.5-1 × 108/mL) are incubated with the indicated agonists. Platelet activation is measured by P-selectin surface expression using PE-antihuman P-selectin and flow cytometry. Results are expressed as percent inhibition of P-selectin surface expression.
1

References

Chemical Information

Download ML161 SDF
Molecular Weight (MW) 361.23
Formula

C17H17BrN2O2

CAS No. 423735-93-7
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Syonnyms N/A
Solubility (25°C) * In vitro DMSO 72 mg/mL (199 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name Benzamide, 2-bromo-N-[3-[(1-oxobutyl)amino]phenyl]-

Preparing Stock Solutions

Stock Solution (1ml DMSO) 1mM 10mM 20mM 30mM
Mass(mg) 0.36123 3.6123 7.2246 10.8369

Research Area

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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