ML161 (Parmodulin 2)

ML161 (Parmodulin 2) is an allosteric inhibitor of PAR1 with IC50 of 0.26 μM.

ML161 (Parmodulin 2) Chemical Structure

ML161 (Parmodulin 2) Chemical Structure

CAS: 423735-93-7

Purity & Quality Control

Batch: S291601 DMSO] 72 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.47%
99.47

ML161 (Parmodulin 2) Related Products

Choose Selective PAR Inhibitors

Biological Activity

Description ML161 (Parmodulin 2) is an allosteric inhibitor of PAR1 with IC50 of 0.26 μM.
Targets
PAR1 [1]
(Cell-free assay)
0.26 μM
In vitro
In vitro ML-161 is an allosteric inhibitor of PAR1. ML-161 displays dose-dependent inhibition of thrombin-induced platelet activation, as measured by P-selectin expression. ML-161 displays selective inhibition of SFLLRN and thrombin-induced platelet aggregation, both of which operate via PAR1, and has no effect on AYPGKF, thromboxane, or ADP-induced platelet aggregation, which are all agonists at alternative platelet GPCRs. [1]

Chemical Information & Solubility

Molecular Weight 361.23 Formula

C17H17BrN2O2

CAS No. 423735-93-7 SDF Download ML161 (Parmodulin 2) SDF
Smiles CCCC(=O)NC1=CC(=CC=C1)NC(=O)C2=CC=CC=C2Br
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 72 mg/mL ( (199.31 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy ML161 (Parmodulin 2) | ML161 (Parmodulin 2) supplier | purchase ML161 (Parmodulin 2) | ML161 (Parmodulin 2) cost | ML161 (Parmodulin 2) manufacturer | order ML161 (Parmodulin 2) | ML161 (Parmodulin 2) distributor