Home Metabolism PPAR agonist Seladelpar For research use only.

Seladelpar

Synonyms: MBX-8025

Seladelpar(MBX-8025) is a potent and selective agonist of peroxisome proliferator–activated receptor-delta (PPAR-δ) with EC50 of 2 nM for human PPAR-δ. MBX-8025 enhances insulin sensitivity, counters dyslipidemia, and reduces hepatic storage of lipotoxic lipids, thereby ameliorating NASH pathology in obese diabetic mice.

Seladelpar Chemical Structure

Seladelpar Chemical Structure

CAS: 851528-79-5(freebase)

Purity & Quality Control

Batch: S663501 DMSO] 89 mg/mL] false] Water] 89 mg/mL] false] Ethanol] 89 mg/mL] false Purity: 99.02%
99.02

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Signaling Pathway

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Biological Activity

Description Seladelpar(MBX-8025) is a potent and selective agonist of peroxisome proliferator–activated receptor-delta (PPAR-δ) with EC50 of 2 nM for human PPAR-δ. MBX-8025 enhances insulin sensitivity, counters dyslipidemia, and reduces hepatic storage of lipotoxic lipids, thereby ameliorating NASH pathology in obese diabetic mice.
Targets
PPAR-δ [1]
(Cell-free assay)
2 nM(EC50)

Chemical Information & Solubility

Molecular Weight 444.47 Formula

C21H23F3O5S
CAS No. 851528-79-5(freebase) SDF Download Seladelpar SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 89 mg/mL ( (200.23 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 89 mg/mL

Ethanol : 89 mg/mL


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In vivo
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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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