Home GPCR & G Protein Glucagon Receptor antagonist Adomeglivant For research use only.

Adomeglivant

Synonyms: LY2409021

Adomeglivant (LY2409021) is a potent and selective antagonist of glucagon receptor that is used as a chronic treatment for type 2 diabetes.

Adomeglivant Chemical Structure

Adomeglivant Chemical Structure

CAS: 1488363-78-5

Purity & Quality Control

Batch: S055501 DMSO] 100 mg/mL] false] Ethanol] 100 mg/mL] false] Water] Insoluble] false Purity: 99.27%
99.27

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Choose Selective Glucagon Receptor Inhibitors

Biological Activity

Description Adomeglivant (LY2409021) is a potent and selective antagonist of glucagon receptor that is used as a chronic treatment for type 2 diabetes.
Targets
Glucagon Receptor [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02385084 Terminated
Healthy
Eli Lilly and Company
 March 2015 Phase 1
NCT02217618 Completed
Healthy Participants
Eli Lilly and Company
 August 2014 Phase 1
NCT02091362 Completed
Type 2 Diabetes Mellitus
Eli Lilly and Company
 March 2014 Phase 2
NCT01929109 Completed
Kidney Failure Chronic|Renal Insufficiency Chronic
Eli Lilly and Company
 August 2013 Phase 1

Chemical Information & Solubility

Molecular Weight 555.63 Formula

C32H36F3NO4
CAS No. 1488363-78-5 SDF --
Smiles CC1=CC(=CC(=C1C2=CC=C(C=C2)C(C)(C)C)C)OC(CCC(F)(F)F)C3=CC=C(C=C3)C(=O)NCCC(=O)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (179.97 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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