Catalog No.S8256 Synonyms: Victoza, Liraglutida, Liraglutidum, NN2211, NN-2211

Liraglutide Chemical Structure

Molecular Weight(MW): 3751.25

Liraglutide is a long-acting glucagon-like peptide-1(GLP-1) receptor agonist.

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Biological Activity

Description Liraglutide is a long-acting glucagon-like peptide-1(GLP-1) receptor agonist.
GLP-1 receptor [1]
In vitro

Liraglutide attenuates induction of plasminogen activator inhibitor type-1 (PAI-1) and vascular adhesion molecule (VAM) expression in human vascular endothelial cells (hVECs) in vitro and may afford protection against endothelial cell dysfunction (ECD), an early abnormality in diabetic vascular disease. In vitro studies demonstrates GLP-1R-dependent liraglutide-mediated inhibition of stimulated PAI-1 and VAM expression[3].

In vivo In vivo studies of vascular reactivity and immunohistochemical analysis are performed in the ApoE-/- mouse model. They demonstrate significant improvement in endothelial function in liraglutide treated mice, a GLP-1R dependent effect. Liraglutide treatment also increases endothelial nitric oxide synthase (eNOS) and reduces intercellular adhesion molecule-1 (ICAM-1) expression in aortic endothelium, an effect again dependent on the GLP-1R[3]. Liraglutide reduces hyperglycemia in T2D mouse models by increasing pancreatic b cell mass through enhanced proliferation[2].


Cell Research:


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  • Cell lines: human umbilical vein endothelial cell line C11-STH20
  • Concentrations: 100 nM
  • Incubation Time: 16 h
  • Method:

    C11-STH cells are cultured to confluence at 37°C in gelatin-coated Nunclon cell culture dishes in Media-199 supplemented with penicillin/streptomycin, 20% FCS, 20 µg/ml endothelial cell growth factor and 20 µg/ml heparin. C11-STH cells are incubated under serum free conditions with liraglutide (100 nM) or the GLP-1 receptor antagonist exendin (9-39) (100 nM) alone or with 10 ng/ml TNFα for 16 h alone or in combination with liraglutide and/or exendin (9-39). ELISA assays for VCAM-1 and ICAM-1 are performed using conditioned medium from C11-STH cells to determine protein expression levels.

    (Only for Reference)
Animal Research:


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  • Animal Models: Athymic nude mice
  • Formulation: Saline
  • Dosages: 300 μg/kg/day
  • Administration: s.c.
    (Only for Reference)

Solubility (25°C)

In vitro Water 100 mg/mL (26.65 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 3751.25


CAS No. 204656-20-2
Storage powder
in solvent
Synonyms Victoza, Liraglutida, Liraglutidum, NN2211, NN-2211

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Frequently Asked Questions

  • Question 1:

    I want to know whether S8256 Liraglutide is free base or salt form?

  • Answer:

    Our S8256 Liraglutide is a TFA salt.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID