Home Metabolism Carbohydrate Metabolism inhibitor Ketohexokinase inhibitor 1 For research use only.

Ketohexokinase inhibitor 1

Synonyms: PF-06835919, MDK1846

Ketohexokinase inhibitor 1 (PF-06835919, MDK1846) is a potent inhibitor of ketohexokinase (KHK) with IC50 of 8.4 nM and 66 nM for KHK-C and KHK-A, respectively.

Ketohexokinase inhibitor 1 Chemical Structure

Ketohexokinase inhibitor 1 Chemical Structure

CAS: 2102501-84-6

Purity & Quality Control

Batch: Purity: 99.59%
99.59

Ketohexokinase inhibitor 1 Related Products

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Biological Activity

Description Ketohexokinase inhibitor 1 (PF-06835919, MDK1846) is a potent inhibitor of ketohexokinase (KHK) with IC50 of 8.4 nM and 66 nM for KHK-C and KHK-A, respectively.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04427917 Completed
Healthy
Pfizer
 November 24 2020 Phase 1
NCT02974374 Completed
Non-alcoholic Fatty Liver Disease
Pfizer
 October 2016 Phase 1

Chemical Information & Solubility

Molecular Weight 356.34 Formula

C16H19F3N4O2
CAS No. 2102501-84-6 SDF --
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 71 mg/mL ( (199.24 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 71 mg/mL

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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