Home Transmembrane Transporters Sodium Channel inhibitor Ibutilide Fumarate

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Ibutilide Fumarate Sodium Channel inhibitor

Cat.No.S2118

Ibutilide Fumarate (U-70226E,Corvert Fumarate) is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm by induction of slow inward sodium current, which prolongs action potential and refractory period of myocardial cells.
Ibutilide Fumarate Sodium Channel inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 885.23

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Quality Control

Batch: Purity: 99.97%
99.97

Solubility

In vitro
Batch:

DMSO : 89 mg/mL (100.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 89 mg/mL

Ethanol : 89 mg/mL

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 885.23 Formula

(C20H36N2O3S)2.C4H4O4

 Storage (From the date of receipt)
CAS No. 122647-32-9 Download SDF Storage of Stock Solutions

Synonyms U-70226E,Corvert Fumarate SMILES CCCCCCCN(CC)CCCC(C1=CC=C(C=C1)NS(=O)(=O)C)O.CCCCCCCN(CC)CCCC(C1=CC=C(C=C1)NS(=O)(=O)C)O.C(=CC(=O)O)C(=O)O

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Mechanism of Action

Targets/IC50/Ki
Sodium channel

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-03-19)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04675788 COMPLETED
Long QT Syndrome; Abnormalities, Drug-Induced
Indiana University
 2021-09-02 PHASE4
NCT03834883 COMPLETED
Long QT Syndrome; Abnormalities, Drug-Induced
Indiana University
 2019-03-26 PHASE4
NCT03834883 Active not recruiting
Long QT Syndrome|Abnormalities Drug-Induced
Indiana University|American Heart Association|Purdue University
 2019-03-26 Phase 4
NCT03370536 TERMINATED
Atrial Fibrillation; Persistent Atrial Fibrillation
Vivek Reddy
 2017-11-01
NCT02513940 COMPLETED
Long QT Syndrome
Indiana University
 2016-05 PHASE4
NCT00589992 UNKNOWN
Atrial Fibrillation; Pulmonary Vein Ablation
Ball Memorial Hospital
 2007-10

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