Home Endocrinology & Hormones Androgen Receptor modulator GSK-2881078 For research use only.

GSK-2881078

GSK 2881078 is a nonsteroidal selective modulator of androgen receptor that is potentially used for the treatment of cachexia.

GSK-2881078 Chemical Structure

GSK-2881078 Chemical Structure

CAS: 1539314-06-1

Purity & Quality Control

Batch: S027601 DMSO] 66 mg/mL] false] Ethanol] 50 mg/mL] false] Water] ˂1 mg/mL] false Purity: 99.89%
99.89

GSK-2881078 Related Products

Signaling Pathway

Androgen Receptor Signaling Pathways

Androgen Receptor Signaling Pathway

Choose Selective Androgen Receptor Inhibitors

Biological Activity

Description GSK 2881078 is a nonsteroidal selective modulator of androgen receptor that is potentially used for the treatment of cachexia.
Targets
androgen receptor [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03359473 Completed
Cachexia
GlaxoSmithKline|Parexel
 February 28 2018 Phase 2
NCT02567773 Completed
Cachexia
GlaxoSmithKline
 September 2015 Phase 1

Chemical Information & Solubility

Molecular Weight 330.33 Formula

C14H13F3N2O2S
CAS No. 1539314-06-1 SDF --
Smiles CC(CS(=O)(=O)C)N1C=CC2=C1C=CC(=C2C(F)(F)F)C#N
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 66 mg/mL ( (199.8 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 50 mg/mL

Water : ˂1 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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