EUK 134
Catalog No.S4261
Molecular Weight(MW): 416.74
EUK 134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.
Purity & Quality Control
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Biological Activity
| Description | EUK 134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril. | |
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| In vitro |
EUK 134 shows potent catalase and SOD activities, and protects human fibroblasts against cytotoxicity by glucose and glucose oxidase. [1] EUK 134 (20 μM) prevents Aβ-induced microglial proliferation in vitro. [2] In SK-N-MC cells, EUK134 protects neuronal cells against H(2)O(2) toxicity by attenuating oxidative stress through inhibition of MAPK pathway, and also results in decreased expression of pro-apoptotic genes p53 and Bax as well as enhanced expression of anti-apoptotic Bcl-2 gene. [3] EUK 134 significantly inhibits amyloid formation at two molar ratios of 1:1 and 5:1 (drugs to protein). [4] |
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| In vivo | EUK 134 (2.5 mg/kg), in a middle cerebral artery occlusion model, significantly reduces brain infarct size, and apparently prevents further infarct growth. [1] EUK-134 prevents oxidative stress and attenuates rat brain damage induced by systemic administration of systemic kainic acid (KA). [5] |
Protocol
| Animal Research:[1] |
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Solubility (25°C)
| In vitro | DMSO | 83 mg/mL (199.16 mM) |
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| Water | 13 mg/mL (31.19 mM) | |
| Ethanol | Insoluble |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 416.74 |
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| Formula | C18H18ClMnN2O4 |
| CAS No. | 81065-76-1 |
| Storage | powder |
| Synonyms | N/A |
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