Doxylamine Succinate

Catalog No.S4240

Doxylamine Succinate Chemical Structure

Molecular Weight(MW): 388.46

Doxylamine succinate competitively inhibits histamine at H1 receptors with substantial sedative and anticholinergic effects.

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Biological Activity

Description Doxylamine succinate competitively inhibits histamine at H1 receptors with substantial sedative and anticholinergic effects.
Targets
Histamine H1 receptor [1]
In vivo The effects of doxylamine (as the succinate salt) on microsomal enzyme activity and serum thyroid hormone levels are examined in B6C3F1 mice following dietary exposure for 7 or 15 days (0, 40, 375, 750, or 1500 ppm in diet, expressed as free base doxylamine). The results suggest that doxylamine is a phenobarbital-type inducer of liver microsomal cytochrome P450 in B6C3F1 mice, and consistent with the hypothesis that doxylamine increases the activity of those hepatic enzymes involved in T4 metabolism.

Protocol

Solubility (25°C)

In vitro DMSO 78 mg/mL (200.79 mM)
Water 78 mg/mL (200.79 mM)
Ethanol 78 mg/mL (200.79 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 388.46
Formula

C17H22N2O.C4H6O4

CAS No. 562-10-7
Storage powder
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00796315 Completed Allergic Rhinitis|Upper Respiratory Infection Procter and Gamble|Consumer Healthcare Products Association December 2008 Phase 1
NCT00614445 Completed Nausea and Vomiting of Pregnancy Duchesnay Inc.|Premier Research Group plc January 2008 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Histamine Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID