Catalog No.S3075

Dexmedetomidine Chemical Structure

Molecular Weight(MW): 200.28

Dexmedetomidine is a sedative medication used by intensive care units and anesthetists.

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In DMSO USD 130 In stock
USD 97 In stock
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Biological Activity

Description Dexmedetomidine is a sedative medication used by intensive care units and anesthetists.
α2 receptor [1]
1.08 nM(Ki )
In vitro

Dexmedetomidine has a relatively high ratio of α2/α1-activity (1620:1 as compared with 220:1 for clonidine) and, therefore, is considered a full agonist of the α2 receptor. This may result in more potent effects of sedation without unwanted cardiovascular effects from α1 receptor activation. The 2-h half-life of dexmedetomidine is nearly 4-fold shorter than that of clonidine, which increases the likelihood that a continuous infusion of dexmedetomidine might be useful for sedation. Dexmedetomidine also has minimum alveolar anesthetic concentration (MAC)-sparing properties, but its use as an anesthetic adjuvant has been complicated by persistent hypotension that has mandated IV fluid administration and vasopressor administration. In addition, its use in large doses is complicated by hypertension from α2 receptor-mediated vascular constriction.


Solubility (25°C)

In vitro DMSO 40 mg/mL (199.72 mM)
Ethanol 40 mg/mL (199.72 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 200.28


CAS No. 113775-47-6
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02856594 Not yet recruiting Postoperative Delirium|Sleep|Anesthesia Massachusetts General Hospital|National Institutes of Health (NIH) February 2017 --
NCT02807467 Recruiting Delirium University Hospital, Basel, Switzerland January 2017 Phase 4
NCT02987985 Not yet recruiting Anesthesia|General Anesthesia|Analgesics, Opioid|Postoperative Complications|Pathologic Processes|Physiologic Effects of Drugs|Narcotics|Analgesics|Sleep Disordered Breathing|Obstructive Sleep Apnea of Child|Tonsillectomy|Respiratory Depression|Dexmedetomidine|Ketamine|Lidocaine|Gabapentin|Pulse Oximetry University of Saskatchewan January 2017 Phase 3
NCT03024957 Recruiting Immune System Suppression Assiut University January 2017 Phase 1|Phase 2
NCT02985697 Not yet recruiting Safety and Efficacy of Intranasal Dexmedetomidine Bon Secours Pediatric Dental Associates January 2017 Phase 4
NCT03012984 Recruiting Elderly|Surgery|Analgesia|Dexmedetomidine|Complication, Postoperative|Delirium Peking University First Hospital January 2017 Phase 4

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