Molecular Weight(MW): 200.28
Dexmedetomidine is a sedative medication used by intensive care units and anesthetists.
Purity & Quality Control
Choose Selective Adrenergic Receptor Inhibitors
|Description||Dexmedetomidine is a sedative medication used by intensive care units and anesthetists.|
Dexmedetomidine has a relatively high ratio of α2/α1-activity (1620:1 as compared with 220:1 for clonidine) and, therefore, is considered a full agonist of the α2 receptor. This may result in more potent effects of sedation without unwanted cardiovascular effects from α1 receptor activation. The 2-h half-life of dexmedetomidine is nearly 4-fold shorter than that of clonidine, which increases the likelihood that a continuous infusion of dexmedetomidine might be useful for sedation. Dexmedetomidine also has minimum alveolar anesthetic concentration (MAC)-sparing properties, but its use as an anesthetic adjuvant has been complicated by persistent hypotension that has mandated IV fluid administration and vasopressor administration. In addition, its use in large doses is complicated by hypertension from α2 receptor-mediated vascular constriction.
|In vitro||DMSO||40 mg/mL (199.72 mM)|
|Water||40 mg/mL (199.72 mM)|
|Ethanol||40 mg/mL (199.72 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02856594||Not yet recruiting||Postoperative Delirium|Sleep|Anesthesia||Massachusetts General Hospital|National Institutes of Health (NIH)||February 2017||--|
|NCT02807467||Recruiting||Delirium||University Hospital, Basel, Switzerland||January 2017||Phase 4|
|NCT02987985||Not yet recruiting||Anesthesia|General Anesthesia|Analgesics, Opioid|Postoperative Complications|Pathologic Processes|Physiologic Effects of Drugs|Narcotics|Analgesics|Sleep Disordered Breathing|Obstructive Sleep Apnea of Child|Tonsillectomy|Respiratory Depression|Dexmedetomidine|Ketamine|Lidocaine|Gabapentin|Pulse Oximetry||University of Saskatchewan||January 2017||Phase 3|
|NCT03024957||Recruiting||Immune System Suppression||Assiut University||January 2017||Phase 1|Phase 2|
|NCT02985697||Not yet recruiting||Safety and Efficacy of Intranasal Dexmedetomidine||Bon Secours Pediatric Dental Associates||January 2017||Phase 4|
|NCT03012984||Recruiting||Elderly|Surgery|Analgesia|Dexmedetomidine|Complication, Postoperative|Delirium||Peking University First Hospital||January 2017||Phase 4|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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