Home PI3K/Akt/mTOR PTEN inhibitor bpV (HOpic) For research use only.

bpV (HOpic)

Synonyms: Bisperoxovanadium (HOpic)

bpV (HOpic) (Bisperoxovanadium (HOpic)) is a potent inhibitor of PTEN with an IC50 of 14 nM. The IC50s for PTP-β and PTP-1B are about 350- and 1800-fold higher than the IC50 for PTEN, respectively.

bpV (HOpic) Chemical Structure

bpV (HOpic) Chemical Structure

CAS: 722494-26-0

Selleck's bpV (HOpic) has been cited by 16 publications

Purity & Quality Control

Batch: S865101 Water] 69 mg/mL] false] DMSO] Insoluble] false] Ethanol] Insoluble] false Purity: 99.53%
99.53

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Biological Activity

Description bpV (HOpic) (Bisperoxovanadium (HOpic)) is a potent inhibitor of PTEN with an IC50 of 14 nM. The IC50s for PTP-β and PTP-1B are about 350- and 1800-fold higher than the IC50 for PTEN, respectively.
Targets
PTEN [1]
(Cell-free assay)
14 nM
In vitro
In vitro 1 μM BpV(Hopic) treatment is capable of increasing the in vitro migration of C2C12 myoblasts, without significantly reducing their ability to differentiate and fuse into multinucleated myotubes. The effects on myoblast migration is in conjuction with enhanced AKT and ERK1/2 signaling[2].
Cell Research Cell lines C2C12 myoblasts
Concentrations 1 μM or 10 μM
Incubation Time 72 h
Method

C2C12 myoblasts are grown to high confluency and triggered to differentiate in the presence of DM, supplemented with 1 μM or 10 μM BpV(Hopic).
In Vivo
In vivo Pharmacological inhibition of PTEN with bpV(HOpic) exacerbates renal dysfunction and promotes tubular damage in mice with IRI(renal ischemia/reperfusion injury) compared with vehicle-treated mice with IRI. PTEN inhibition enhances tubular cell apoptosis in kidneys with IRI, which is associated with excessive caspase-3 activation. Furthermore, PTEN inhibition expands the infiltration of neutrophils and macrophages into kidneys with IRI, which is accompanied by increased expression of the proinflammatory molecules[3].
Animal Research Animal Models mouse model of ischemia-reperfusion injury (C57BL/6 mice, 8-12 weeks old)
Dosages 200 μg/kg
Administration i.p.

Chemical Information & Solubility

Molecular Weight 347.24 Formula

C6H4NO8V.2K
CAS No. 722494-26-0 SDF --
Smiles [K+].[K+].OC1=CC=C2N(=C1)|[V+3]|3|4(|[O-][O-]|3)(|[O-][O-]|4)(|[O-]C2=O)=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 69 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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