Home Transmembrane Transporters TRP Channel agonist Borneol For research use only.

Borneol

Borneol is a bicyclic monoterpenoid compound extracted from medicinal plants such as Blumea balsamifera, and Dryobalanops aromatica. It is a TRPM8 agonist that increases ocular surface wetness.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.

Borneol Chemical Structure

Borneol Chemical Structure

CAS: 507-70-0

Purity & Quality Control

Batch: S360501 DMSO] 30 mg/mL] false] Ethanol] 30 mg/mL] false] Water] Insoluble] false Purity: 99.86%
99.86

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Biological Activity

Description Borneol is a bicyclic monoterpenoid compound extracted from medicinal plants such as Blumea balsamifera, and Dryobalanops aromatica. It is a TRPM8 agonist that increases ocular surface wetness.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
Targets
TRPM8 [2]
(cell-based assay)
65 μM(EC50)
In vitro
In vitro Borneol activates TRPM8 channel in a temperature- and dose-dependent manner. Borneol at micromolar concentrations do not affect the viability of human corneal epithelial cells. Borneol has been found to activate TRPV3 channel, which belongs to the heat-activated vanilloid family of TRP channels[1]. Borneol can potentiate (EC50 = 248 μM) or directly activate (> 1.5 mM) the GABAA receptor, activate the TRPV3 channel (EC50 = 3.45 ± 0.13 mM), and inhibit the TRPA1 channel (IC50 = 0.5 ± 0.3 or 0.20 ± 0.06 mM)[2].
Cell Research Cell lines HEK293 and HCE cells
Concentrations --
Incubation Time 24 h
Method

The viability of HEK293 and HCE cells is measured with WST-1 reagent. Briefly, cells are seeded in 96-well plates to reach a confluency of 50–60%. Borneol or menthol is added into the cell culture medium and incubated for 24 h. WST-1 (10 μl) is then added into each well and incubated for 2 h. Absorbance at 450 nm (A450) and 690 nm (A690) is measured in a plate reader. The subtracted value (A450-A690) is used to evaluate viability of the cells.
In Vivo
In vivo Borneol is widely used in ophthalmic preparations and classic formulas of Traditional Chinese Medicine to treat various diseases including oculopathies, oral ulcers, sore throat, skin diseases and mild neurological disorders, and found to produce anti-inflammatory, anti-bacterial and analgesic effects. Borneol can increase tear secretion via activating the cold-sensing TRPM8 channel in the cornea[1]. borneol may facilitate the delivery of other effective components and enhance their effects in combinatorial herbal formulas. Thus, borneol is also orally administered as an adjuvant component for the treatment of a variety of diseases. topical borneol provides analgesic effects in three different mouse models of pain[2].
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05559307 Recruiting
Ischemic Stroke Acute
Ying Gao|Beijing Chaoyang Integrative Medicine Rescue and First Aid Hospital|Dongzhimen Hospital Beijing
 August 16 2022 Phase 4

Chemical Information & Solubility

Molecular Weight 154.25 Formula

C10H18O
CAS No. 507-70-0 SDF Download Borneol SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 30 mg/mL ( (194.48 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 30 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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