Home MAPK ERK inhibitor BAY-885 For research use only.

BAY-885

BAY-885 is a highly potent and selective ERK5 inhibitor.

BAY-885 Chemical Structure

BAY-885 Chemical Structure

CAS: 2307249-33-6

Selleck's BAY-885 has been cited by 1 publication

Purity & Quality Control

Batch: S889601 DMSO] 30 mg/mL] false] Ethanol] 8 mg/mL] false] Water] Insoluble] false Purity: 99.65%
99.65

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Biological Activity

Description BAY-885 is a highly potent and selective ERK5 inhibitor.
Targets
ERK5 [1]
In vitro
In vitro

BAY-885 shows potent ERK5 kinase and transcriptional inhibition in the SN12C-MEF2 reporter cell line (IC50 = 115 nM/IC90 = 691 nM) and has no effects on a reporter control cell line with constitutive luciferase expression (SN12C-CMV-luc, IC50 > 30 μM), thereby ruling out potential effects as a general inhibitor of transcription or translation.[1]
Cell Research Cell lines BT-474, SK-BR-3, SNU-449, NCIH460, SN12C, MFM-223
Concentrations 0.07 nM - 20 μM
Incubation Time 16 h
Method

On day 1, the cells are seeded in 384-well white plates at a density of 10,000 cells per well in 20 μL of culture medium. On day 2, the test compounds including BAY-885 are added in serial dilutions using the HP D300 Digital Dispenser and incubated at 37 °C for 16 h.

Chemical Information & Solubility

Molecular Weight 515.53 Formula

C25H28F3N7O2
CAS No. 2307249-33-6 SDF --
Smiles CN1CCN(CC1)C2=CC3=C(C(=NC=N3)C4CCN(CC4)C(=O)C5=C(C=C(C=C5)OC(F)(F)F)N)N=C2
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 30 mg/mL ( (58.19 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 8 mg/mL

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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