Catalog No.S2868 Synonyms: SYR-322
Molecular Weight(MW): 461.51
Alogliptin is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.
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|Description||Alogliptin is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.|
Alogliptin(SYR-322) is a potent inhibitor of DPP-4 and exhibits greater than 10,000 fold selectivity over the closely related serine proteases DPP-8 and DPP-9. Alogliptin is not an inhibitor of CYP-450 enzymes and does not block the hERG channel at concentrations up to 30 μM. 
|In vivo||Alogliptin(SYR-322) produces dose-dependent improvements in glucose tolerance and increases plasma insulin levels in female Wistar fatty rats.  Acute administration of alogliptin results in a significant decrease in plasma DPP-4 activity, and increases plasma active GLP-1. Alogliptin improves glucose tolerance at a dose of 0.3 mg/kg and higher, with a dose-dependent increase in plasma IRI, suggesting that improved glucose tolerance results from the ability of alogliptin to enhance insulin secretion. |
|In vitro||DMSO||68 mg/mL (147.34 mM)|
|Water||2 mg/mL (4.33 mM)|
|In vivo||Add solvents individually and in order:
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03042325||Not yet recruiting||Diabetes Mellitus, Type 2||Takeda||March 2017||Phase 4|
|NCT02989649||Recruiting||Diabetes Mellitus, Type 2||Takeda||December 2016||--|
|NCT02856113||Recruiting||Diabetes Mellitus, Type 2||Takeda||November 2016||Phase 3|
|NCT02756832||Recruiting||Diabetes Mellitus||Takeda||September 2016||Phase 4|
|NCT02771093||Recruiting||Type 2 Diabetes Mellitus||Takeda||July 2016||Phase 4|
|NCT02763007||Not yet recruiting||Diabetes Mellitus, Type 2||Kun-Ho Yoon|Takeda|The Catholic University of Korea||May 2016||Phase 4|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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