Rolipram Chemical Structure
Cilomilast (SB-207499) is among the first of a new generation of PDE4 inhibitors (Ki ≈100 nM).
Pimobendan (Vetmedin) is a selective inhibitor of phosphodiesterase III (PDE III) with an IC50 of 0.32 μM.
S-(+)-Rolipram is a less active enantiomer of the PDE4 inhibitor with an EC50 of 1.0 μM
GSK256066 is an exceptionally high affinity and selective PDE4 inhibitor with an IC50 of 3.2 pM for PDE4B.
PF-2545920 a highly selective and potent PDE10A inhibitor with an IC50 of 0.37 nM.
LY315920(Varespladib) is a sPLA2 inhibitor (IC50 of 9.6 ±1 nM)
Abiraterone (CB-7598) is a potent steroidal cytochrome P450 17alpha-hydroxylase-17,20-lyase (CYP17) inhibitor with an IC50 at 4 nM.
Bicalutamide (Casodex) is an active competitive non-steroidal androgen receptor antagonist.
Inhibitor of the 17,20 lyase.
MDV3100 (Enzalutamide) is androgen-receptor inhibitor. Highly recommended inhibitor in AR research.
Rolipram is a PDE4-inhibitor. Like most PDE4-inhibitors, it is an anti-inflammatory drug. Rolipram is being studied as a possible alternative to current antidepressants. Recent studies show that rolipram may have antipsychotic effects. [1]
| Molecular Weight (WM): | 275.34 |
|---|---|
| Formula: | C16H21NO3 |
| CAS No.: | 61413-54-5 |
| Synonyms: |
N/A
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| Dissolve in (25°C): | DMSO ≥55mg/mL |
| Water <1mg/mL | |
| Ethanol ≥55mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
A collection of 864 bioactive compounds
A collection of 481 inhibitors
A collection of 194 kinase inhibitors
A collection of 85 tyrosine kinase inhibitors.
A collection of 426 FDA approved drugs
A collection of 139 natural products
A collection of 40 chemotherapeutic agents
A unique collection of 17 small molecule modulators
A unique collection of 47 small molecule inhibitors
A unique collection of 63 GPCR small molecules
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