TAE684 (NVP-TAE684)

Related ALK Inhibitors

• GSK1838705A

  GSK1838705A is a potent inhibitor of IGF-1R, IR and ALK with IC50 of 2.0 nM, 1.6 nM and 0.5 nM, respectively

• CH5424802

  CH5424802 is a potent and selective ALK inhibitor with IC50 of 1.9 nM.

• AP26113

  AP26113 is a potent ALK inhibitor for ALK, FER, ROS/ROS1, FLT3 and FES/FPS with IC50 of 0.62 nM, 1.3 nM, 1.9 nM, 2.1 nM and 3.4 nM, respectively.

• CEP-28122

  CEP-28122 is a highly potent and selective orally active ALK inhibitor with IC50 of 1.9 nM.

• Linifanib (ABT-869)

  Linifanib (ABT-869) is a novel, potent ATP-competitive RTK inhibitor for KDR, CSF-1R, Flt-1, Flt-3 and PDGFRβ with IC50 of 4 nM, 3 nM, 3 nM, 3 nM, and 66 nM respectively.

• BIBF1120 (Vargatef)

  BIBF1120 (Vargatef) is a potent inhibitor of VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.

• Afatinib (BIBW2992)

  BIBW2992 (Afatinib, Tomtovok, Tovok) irreversibly inhibits EGFR/HER2 including EGFR^wt, EGFR^L858R, EGFR^L858R/T790M and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively.

• BMS-536924

  BMS-536924 is an ATP-competitive IGF-1R and IR inhibitor with IC50 of 100 nM and 73 nM, respectively.

• Cediranib (AZD2171)

  Cediranib (AZD2171) is a highly potent VEGFR2 inhibitor with IC50 of 0.5 nM, also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM.

• CI-1033 (Canertinib)

  CI-1033 is a potent inhibitor of EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, respectively.