Catalog No.S2484 Synonyms: Win 47203

Milrinone Chemical Structure

Molecular Weight(MW): 211.22

Milrinone is a phosphodiesterase 3 (PDE3) inhibitor, used to increase the heart's contractility.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
USD 970 In stock
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1 Customer Review

  • Viability of H9c2 cells incubated with MRN-HSA-NPs (black bars) compared with MRN-Lactate (grey bars) at different MRN concentrations, at (a) 4 hours, (b) 24 hours and (c) 48 hours. The graph shows a representative result of mean±SD (n=3). ****P<0.0001, ***P<0.001, **P<0.01 and *P<0.05 were considered significant based on Sidak’s posthoc analysis.

    Mol Pharm, 2017, doi: 10.1021/acs.molpharmaceut.7b00360. Milrinone purchased from Selleck.

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Biological Activity

Description Milrinone is a phosphodiesterase 3 (PDE3) inhibitor, used to increase the heart's contractility.
ATPase [1] PDE3 [7] PDE2 [7]
2.1 μM 5.2 μM
In vitro

Milrinone causes a concentration-dependent increase in the cAMP level in rabbit and human platelets with similar potency. Milrinone inhibits human platelet aggregation with a median inhibitory concentration (IC50) of 2 mM.Milrinone concentration-dependently increases left ventricular developed pressure (LVDP) and contractility. Milrinone concentration-dependently increases cAMP in rabbit coronary smooth muscle cells. [1] Milrinone increases intracellular cyclic adenosine monophosphate by inhibiting Type III phosphodiesterase. [2] Milrinone is a potent (IC50 = 0.16-0.90 mM) and selective (100 times peak III relative to peak I) peak III inhibitor. Milrinone significant increases in cAMP content accompany significant vasorelaxation. [3]

In vivo Milrinone inhibits PDE4 in addition to PDE3 activity in the rabbit heart.Milrinone (>10 microM) causes greater elevations in intracellular cAMP and calcium than cilostazol. [4] Milrinone causes similar increases in heart rate, cardiac output, and left ventricular +dP/dt and decreases in end-diastolic pressure and systemic vascular resistance in anaesthetized dogs. [5] Milrinone leads to significant increases in right ventricular function as well as significant improvements in pulmonary vascular resistance, pulmonary blood flow, and left ventricular filling in mongrel dogs underwent pulmonary artery catheterization. [6]


Solubility (25°C)

In vitro DMSO 42 mg/mL (198.84 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 211.22


CAS No. 78415-72-2
Storage powder
in solvent
Synonyms Win 47203

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02951130 Not yet recruiting Congenital Diaphragmatic Hernia|Persistent Pulmonary Hypertension of the Newborn|Hypoxemic Respiratory Failure|Pulmonary Hypoplasia NICHD Neonatal Research Network|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) February 2017 Phase 2
NCT02726620 Recruiting Hypotension Vanderbilt University Medical Center|UMC Utrecht January 2017 --
NCT02712788 Recruiting Cerebral Vasospasm Indiana University April 2016 Phase 2
NCT02644057 Recruiting Cardiorenal Syndrome Maimonides Medical Center March 2016 Phase 2
NCT02549066 Recruiting Complication of Extracorporeal Circulation|Kidney Circulation Disorder|Renal Function Disorder Sahlgrenska University Hospital, Sweden January 2016 --
NCT02640846 Recruiting Septic Shock|Cardiomyopathy Sahlgrenska University Hospital, Sweden December 2015 Phase 4

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PDE Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID