Mianserin HCl

Synonyms: Bolvidon, Norval, Tolvon,ORG GB-94 HCl,Mianserin hydrochloride

Mianserin (Bolvidon, Norval, Tolvon,ORG GB-94 HCl,Mianserin hydrochloride) is an potent antagonist of H1 histamine receptor and 5-HT serotonin receptors, used for the treatment of depression.

Mianserin HCl Chemical Structure

Mianserin HCl Chemical Structure

CAS: 21535-47-7

Selleck's Mianserin HCl has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 100%
100

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Biological Activity

Description Mianserin (Bolvidon, Norval, Tolvon,ORG GB-94 HCl,Mianserin hydrochloride) is an potent antagonist of H1 histamine receptor and 5-HT serotonin receptors, used for the treatment of depression.
Targets
Histamine receptor [1]
In vitro
In vitro

Mianserin (2 mg/kg s.c.) causes a modest increase of DOPAC levels up to about 30% above base-line, which is statistically significant when compared to saline. Mianserin increases extracellular norepinephnne, but a comparison with desipramine and idazoxan showed that both NE reuptake inhibition and alpha-2 autoreceptor blockade contributed to the mianserin-induced increase in extracellular norepinephnne. [1] Mianserin and eltoprazine displays opposite effects in the elevated plus-maze: Mianserin induces anxiolytic-like effects, while eltoprazine shows anxiogenic-like ones. Mianserin treatment induces a decrease in the number of these sites, while eltoprazine treatment results in an increase. [2]

In Vivo
In vivo

Mianserin, which has a small or no effect in noradrenaline (NA) reuptake but may enhance release by blocking presynaptic inhibition mediated by alpha 2-adrenoceptors, induced regeneration of catecholamine fibers in the rat cerebral cortex. [3] Mianserin attenuates the effects of both m-CPP and SKF 38393 in neonatal 6-OHDA-lesioned rats, suggesting that DA agonist effects are mediated by 5-HT neurochemical systems. [4] Mianserin (10 mg/kg, SC) dose-dependently increases up to about 6 times extracellular dopamine in the medial prefrontal cortex of the rat. Mianserin also dose-dependently increases extracellular noradrenaline in the prefrontal cortex. [5]

Chemical Information & Solubility

Molecular Weight 300.83 Formula

C18H20N2·HCl

CAS No. 21535-47-7 SDF Download Mianserin HCl SDF
Smiles CN1CCN2C(C1)C3=CC=CC=C3CC4=CC=CC=C42.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 60 mg/mL ( (199.44 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 30 mg/mL

Ethanol : 21 mg/mL


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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