Catalog No.S1736 Synonyms: AHR 85
Molecular Weight(MW): 241.24
Methocarbamol is a carbonic anhydrase inhibitor, used as a central muscle relaxant to treat skeletal muscle spasms.
Purity & Quality Control
Choose Selective Carbonic Anhydrase Inhibitors
|Description||Methocarbamol is a carbonic anhydrase inhibitor, used as a central muscle relaxant to treat skeletal muscle spasms.|
Methocarbamol is metabolized via dealkylation and hydroxylation followed by conjugation to form both glucuronides and sulfates. 
|In vivo||Methocarbamol results in a median terminal half-life, mean transit time, mean absorption time, and apparent oral clearance of 2.89 hours, 2.67 hours, 0.410 hours, and 16.5 mL/min/kg in the horse. Methocarbamol is rapidly absorbed and extensively metabolized after oral administration to horses as indicated by a short absorption time and modest systemic bioavailability of 54.4% in the horse.  Methocarbamol is a centrally acting muscle relaxant available in both IV and oral forms in cats.  Methocarbamol (100 mg/kg) does not change the heart rate, cardiac output, mean pulmonary arterial blood pressure, systolic, diastolic and mean aortic blood pressure, respiratory rate and arterial blood gases, but mild to moderate depression is observed in five of eight horses administered i.v. Methocarbamol, and in all horses administered oral Methocarbamol. Plasma Methocarbamol concentration declines very rapidly during the initial or rapid disposition phase after i.v. administration; the terminal elimination half-life ranged from 59 minutes to 90 minutes in horse. Peak plasma Methocarbamol concentrations following oral administration occur within 15 to 45 minutes in horse. |
|In vitro||DMSO||48 mg/mL (198.97 mM)|
|Ethanol||48 mg/mL (198.97 mM)|
|Water||2 mg/mL (8.29 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02642874||Not yet recruiting||Liver Cirrhosis||Tanta University||October 2016||Phase 3|
|NCT02831569||Completed||Pain||Boehringer Ingelheim||July 2016||Phase 3|
|NCT02665286||Recruiting||Low Back Pain||Montefiore Medical Center||March 2016||Phase 4|
|NCT02432456||Recruiting||Wounds and Injuries|Rib Fractures||Medical College of Wisconsin||September 2015||Phase 4|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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