Home Metabolism Carbonic Anhydrase inhibitor Methocarbamol

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Methocarbamol Carbonic Anhydrase inhibitor

Cat.No.S1736

Methocarbamol (AHR 85) is a carbonic anhydrase inhibitor, used as a central muscle relaxant to treat skeletal muscle spasms.
Methocarbamol Carbonic Anhydrase inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 241.24

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Quality Control

Batch: S173601 DMSO]48 mg/mL]false]Ethanol]48 mg/mL]false]Water]2 mg/mL]false Purity: 99.79%
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99.79

Solubility

In vitro
Batch:

DMSO : 48 mg/mL (198.97 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 48 mg/mL

Water : 2 mg/mL

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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 241.24 Formula

C11H15NO5

 Storage (From the date of receipt)
CAS No. 532-03-6 Download SDF Storage of Stock Solutions

Synonyms AHR 85 Smiles COC1=CC=CC=C1OCC(COC(=O)N)O

Mechanism of Action

In vitro
Methocarbamol is metabolized via dealkylation and hydroxylation followed by conjugation to form both glucuronides and sulfates.
In vivo
Methocarbamol results in a median terminal half-life, mean transit time, mean absorption time, and apparent oral clearance of 2.89 hours, 2.67 hours, 0.410 hours, and 16.5 mL/min/kg in the horse. This compound is rapidly absorbed and extensively metabolized after oral administration to horses as indicated by a short absorption time and modest systemic bioavailability of 54.4% in the horse. It is a centrally acting muscle relaxant available in both IV and oral forms in cats. This chemical (100 mg/kg) does not change the heart rate, cardiac output, mean pulmonary arterial blood pressure, systolic, diastolic and mean aortic blood pressure, respiratory rate and arterial blood gases, but mild to moderate depression is observed in five of eight horses administered i.v. Methocarbamol, and in all horses administered oral Methocarbamol. Plasma Methocarbamol concentration declines very rapidly during the initial or rapid disposition phase after i.v. administration; the terminal elimination half-life ranged from 59 minutes to 90 minutes in horse. Peak plasma Methocarbamol concentrations following oral administration occur within 15 to 45 minutes in horse.
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