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Methazolastone Chemical Structure
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Biological Activity
In vitro, temozolomide has demonstrated scheduledependent antitumor activity against a variety of malignancies, including glioma, metastatic melanoma, and other difficult-totreat cancers. [1,2]
The spontaneous conversion of temozolomide to MTIC is dependent on pH. Comparison of the half-life of temozolomide in phosphate buffer ((pH 7.4) t1/2 5 1.83 h) with the mean plasma half-life observed in patients after i.v. and p.o. dosing (t1/2 5 1.81 h) indicates that the conversion of temozolomide to MTIC is a chemically controlled reaction with little or no enzymatic component. [3]
Chemical Information
| Molecular Weight (WM): | 194.15 |
|---|---|
| Formula: | C6H6N6O2 |
| CAS No.: | 85622-93-1 |
| Synonyms: |
Temozolomide, Temodar, Temodal
|
| Dissolve in (25°C): | DMSO ≥39mg/mL |
| Water ≥5mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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