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MGCD-265 Chemical Structure
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Biological Activity
MGCD265 is a tyrosine kinase inhibitor that targets the MET, VEGFR-1, VEGFR-2, VEGFR-3, RON and TIE2 receptor tyrosine kinases, which appear to play key roles in tumour development and blood vessel formation (angiogenesis) and tumour survival. MGCD265 is currently in phase I single-agent clinical trials for solid tumour cancers and in phase II trials for solid tumours and NSCLC . [1]
References on MGCD-265
- [1] Cancer Res 2006;66:8715-8721
Chemical Information
| Molecular Weight (WM): | 517.60 |
|---|---|
| Formula: | C26H20FN5O2S2 |
| CAS No.: | 875337-44-3 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥104mg/mL |
| Water <1mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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Western blot analysis of c-Met and p-c-Met. 0-50μM MGCD265 was added.
Western blot analysis of c-Met and p-c-Met. 0-50μM MGCD265 was added.
Data independently produced by Dr. Zhang of Tianjin Medical University MGCD-265 purchased from Selleck
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Western blot analysis of c-Met and p-c-Met. 0-50μM MGCD265 was added.
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Data independently produced by Dr. Zhang of Tianjin Medical University
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