Luteolin

Catalog No.S2320

Luteolin Chemical Structure

Molecular Weight(MW): 286.24

Luteolin is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. Phase 2.

Size Price Stock Quantity  
In DMSO USD 70 In stock
USD 50 In stock
USD 170 In stock
USD 570 In stock
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1 Customer Review

  • Bioactive compounds inhibit recombinant HDAC activity. Recombinant HDACs were incubated with flavonoid Luteolin (C) for 2 h prior to the addition of cell permeable HDAC substrates. Luteolin inhibited activity of most classes I, IIa, and IIb HDAC isoforms.

    Mol Nutr Food Res, 2017. Luteolin purchased from Selleck.

Purity & Quality Control

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Biological Activity

Description Luteolin is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. Phase 2.
Targets
PDE2 [1]
(Cell-free assay)
PDE5 [1]
(Cell-free assay)
PDE4 [1]
(Cell-free assay)
PDE3 [1]
(Cell-free assay)
PDE1 [1]
(Cell-free assay)
6.4 μM(Ki) 9.5 μM(Ki) 11.1 μM(Ki) 13.9 μM(Ki) 15.0 μM(Ki)
In vitro

Luteolin is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. [1] Luteolin inhibits LPS-stimulated TNF-alpha production with an IC50 of less than 1 μM. Luteolin inhibites LPS-induced phosphorylation of Akt as well as IkappaBalpha. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
mouse RAW264.7 cells M3vrdWZ2dmO2aX;uJIF{e2G7 MXGyJIg> MULJcohq[mm2aX;uJI9nKE6RIIDyc4R2[3Srb36gbY4hVFCVLYP0bY12dGG2ZXSgcY92e2ViUlHXNlY1NjdiY3XscJMheHKnLXnuZ5Vj[XSnZDDmc5IhOiCqcoOgZoVnd3KnIFzQV{B{fGmvdXzheIlwdiCob4KgNlQhcHK|IHL5JGdzcWW|czDhd5NigSCvZYToc4QtKEmFNUC9NE4zOSEQvF2= NUnL[|N1OjVzN{[xPFc>
HEK293 FS cells MYHGeY5kfGmxbjDhd5NigQ>? MUDJcohq[mm2aX;uJI9nKE6RWESg[ZhxemW|c3XkJIlvKEiHS{K5N{BHWyClZXzsd{Bie3Onc4Pl[EBieyCKMl:yJJBzd2S3Y4Tpc44h[nliSELPNk9VgXJxTGDPJIF{e2G7LDDJR|UxRTBwOEWg{txO NYLHUphwOjB5M{GzOVc>
CHO cells MY\GeY5kfGmxbjDhd5NigQ>? MV3B[49vcXO2IHHjeIl3cXS7IHH0JJJifCCGQWSg[ZhxemW|c3XkJIlvKEOKTzDj[YxteyxiRVO1NF0yNjR3IN88US=> M1T2elIxQTdzNkWw
human MV4-11 cells NGLETItEgXSxdH;4bYNqfHliYYPzZZk> NEPRcGw4OiCq NYLxbYpZS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVVZ2LUGxJINmdGy|IHjhdoJwemmwZzDGUHQ{KG23dHH0bY9vKGGodHXyJFczKGi{czDifUB1\XS{YYrvcIl2dSCkYYPl[EBGgiCFeWTvfEBk\WyuII\pZYJqdGm2eTDhd5NigSxiR1m1NF0yNjd4IN88US=> NILhN2szOzRzMUC3Ny=>
HEK293 cells NFWzV|lHfW6ldHnvckBie3OjeR?= NWLkTmNWOjRiaB?= NGPiU5lC\2:waYP0JIFkfGm4aYT5JIF1KG2xdYPlJHBRSVKpYX3tZUBmgHC{ZYPz[YQhcW5iSFXLNlk{KGOnbHzzJINwNWW6cILld5Nqdmdid3n0bEBI[Wx2IILldI9zfGW{II\lZ5RweiCjZoTldkAzPCCqcoOgZpkh\HWjbD3seYNq\mW{YYPlJJJmeG:{dHXyJIF{e2G7LDDFR|UxRTJwMzFOwG0> NY\aW2xCOjR7NUW4PFk>
human U2OS cells NWj4PHEyTnWwY4Tpc44h[XO|YYm= MXK1JIg> MWXB[49vcXO2IHHjeIl3cXS7IHH0JGdRWjN3IILlZ4VxfG:{IHnuJIh2dWGwIGWyU3Mh[2WubIOgZ49mgHC{ZYPzbY5oKEejbEStWnAyPi2WRW[gZZN{\XO|ZXSgZZMh[mW2YTDhdpJme3SrbjD0doFve2yxY3H0bY9vKGGodHXyJFUhcHK|IHL5JIJmfGFibHHjeIFu[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTB;Mz6yJO69VQ>? NHS2SJkzPDlyMES0Oy=>
RBL-2H3 cells Mn73SpVv[3Srb36gZZN{[Xl? NYq2dYNvUW6qaXLpeI9zgSCjY4Tpeol1gSCjZ3HpcpN1KEmOLUSgdJJw\HWldHnvckBqdiCUQlytNmg{KGOnbHzzJJdieyCmZYTldo1qdmWmLDDJR|UxRTNwNzFOwG0> MUKxNlk2OTB7Mh?=
human mast cells M1;Vd2Z2dmO2aX;uJIF{e2G7 M37ZTGlvcGmkaYTpc44hd2ZiU2nLJIlvKGi3bXHuJI1ie3RiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJI1ie3RiY3XscEBl\We{YX71cIF1cW:wLDDFR|UxRTRwNTFOwG0> NH2yXowzOjJ3N{KxNy=>
human LNCAP cells M2jBN2Z2dmO2aX;uJIF{e2G7 M2DxSGRwf26{ZXf1cIF1cW:wIH;mJJBzd3O2YYTlJJNx\WOrZnnjJIFvfGmpZX6gd4VkemW2aX;uJIlvKGi3bXHuJGxPS0GSIHPlcIx{NCCLQ{WwQVUh|ryP NX7LNnlIOjVyMUm0O|g>
rat H9c2 cells M{TRZ2Z2dmO2aX;uJIF{e2G7 M3fjZlI1KGh? M1KzWWN6fG:ycn;0[YN1cX[nIHHjeIl3cXS7IHHnZYlve3RiZH;4c5J2[mmlaX6tbY5lfWOnZDDjfZRwfG:6aXPpeJkhcW5icnH0JGg6[zJiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfUwhTUN3ME21MlU{KM7:TR?= MV2yNFk{Ojd4Mh?=
human HT-29 cells M1z0T2Z2dmO2aX;uJIF{e2G7 NVHDb2F[OTBibXnudy=> NF3MUJlC\2:waYP0JIFkfGm4aYT5JIF1KEeSUkO1JJJm[2WydH;yJIlvKGi3bXHuJGhVNTJ7IHPlcIx{KGGodHXyJFExKG2rboOgZpkh\HmwYX3pZ{Bu[XO|IILl[Il{fHKrYoX0bY9vKGG|c3H5MEBGSzVyPUeuNlQh|ryP MUSyOFkxODR2Nx?=
human RS4:11 cells MmmyR5l1d3SxeHnjbZR6KGG|c3H5 MnTtO|IhcA>? MV\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDSV|Q7OTFiY3XscJMhcGG{Yn;ybY5oKHerbHSgeJlx\SCITGSzJIFnfGW{IEeyJIhzeyCkeTD0[ZRz[XqxbHn1cUBj[XOnZDDFfkBEgVSxeDDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhT0l3ME23MlI2KM7:TR?= MY[yN|QyOTB5Mx?=
NCI-H460 cells NFHMU5RHfW6ldHnvckBie3OjeR?= Mn65Nk0zOCCq M2rOfmlvcGmkaYTpc44hd2ZiQVLDS|Ih\XiycnXzd4VlKGmwIHj1cYFvKE6FST3IOFYxKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gVIhCKGGlY4XteYxifGmxbjDh[pRmeiB{IITvJFIxKGi{czDy[YxifGm4ZTD0c{BnfW2rdILlcY9z\2mwIFOsJGlEPTB;OD65JO69VQ>? NXeyTXFmOjF{N{WzPFY>
human H9 cells MlPzSpVv[3Srb36gZZN{[Xl? MmraN{Bl[Xm| MmrBRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXOSB|QjDpcoZm[3SnZDDpckBpfW2jbjDIPUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdoFtKHKncHzpZ4F1cW:wIHHmeIVzKDNiZHH5d{BjgSCyMkSgZY51cWenbjDjZZB1fXKnIHHzd4F6NCCHQ{WwQVExKM7:TR?= MUm4NVU5OTZ2
MDCK cells Ml;SR5l1d3SxeHnjbZR6KGG|c3H5 NUTWboJrS3m2b4TvfIlkcXS7IHHnZYlve3RiTVTDT{Bk\WyuczDifUBOXFRiYYPzZZktKEOFNUC9NVIvPDRizszN Mn7uNVg3PDByNEK=
mouse B16-4A5 cells NX7OeIsxTnWwY4Tpc44h[XO|YYm= M{HPZVczKGh? MYPJcohq[mm2aX;uJI9nKHSqZX;wbJltdGmwZT3zeIlufWyjdHXkJI1mdGGwb3flcoV{cXNiaX6gcY92e2ViQkG2MVRCPSClZXzsd{Bi\nSncjC3NkBpenNuIFnDOVA:OTRizszN Mo\HNlAyQDl|OUm=
K562 cells NFza[JZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnjPOUBl[Xm| MXPHdo94fGhiaX7obYJqfGmxbjDv[kBMPTZ{IHPlcIx{KGK7IGjUWEBie3OjeTDh[pRmeiB3IHThfZMtKEmFNUC9NVQvPjVizszN MYexO|QyOTB7Mh?=
human H9 cells NILnSnJEgXSxdH;4bYNqfHliYYPzZZk> MVezJIRigXN? M1v3eGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGg6KGOnbHzzJIFnfGW{IEOg[IF6eyxiSVO1NF0yPiEQvF2= MmHYPFE2QDF4NB?=
human HT-29 cells MYfGeY5kfGmxbjDhd5NigQ>? NEDlbIMyOCCvaX7z NWPQZnZpTGW|ZX7zbZRqgmG2aX;uJI9nKEeSUkO1JJJm[2WydH;yJIlvKGi3bXHuJGhVNTJ7IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhgmGycnnuZZN1NWmwZIXj[YQh\HmwYX3pZ{Bu[XO|IILl[Il{fHKrYoX0bY9vKGGodHXyJFExKG2rboOsJGlEPTB;MUiuOkDPxE1? MVmyOFkxODR2Nx?=
human U937 cells NHPJO21Rem:uaX\ldoF1cW:wIHHzd4F6 MU[3NkBp NH\yfW9CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGW5N|ch[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IGfTWE05KGG|c3H5MEBKSzVyPUKwJO69VQ>? Mn:4NVcyPThyNUS=
mouse HT22 cells MVjGeY5kfGmxbjDhd5NigQ>? M2DVcFMhcA>? M3\oVW5mfXKxcILveIVkfGm4ZTDhZ5Rqfmm2eTDpckBud3W|ZTDIWFIzKGOnbHzzJIF{e2W|c3XkJIF{KHRvQl;PTE1qdmS3Y3XkJJRwgGmlaYT5JIF1KDRyIIXNJJBz\WmwY4XiZZRm\CCob4KgN{BpenNiZn;scI94\WRiYomgeE1DV0:KIHnu[JVkfGmxbjDt[YF{fXKnZDDh[pRmeiB7IHjyd{BjgSCPVGSgZZN{[Xl? MoG1NlQzPDV7M{m=
human THP1 cells MVXGeY5kfGmxbjDhd5NigQ>? NWDyepNpOjBizszN MkPTNUBp Mo\qSI94dnKnZ4XsZZRqd25ib3[gWHBCNWmwZIXj[YQhVk:[MjDtVm5CKGW6cILld5Nqd25iaX6gbJVu[W5iVFjQNUBk\WyuczDheEAzOCC3TTDpcoN2[mG2ZXSg[o9zKDFiaIKgdJJqd3JidH:gWHBCKGOqYXzs[Y5o\SCvZXHzeZJm\CCjZoTldkAzPCCqcoOgZpkhWlRvUFPSJIFv[Wy7c3nz Mm\qNlM4QDZ3MkC=
MDA-MB-231 cells NIX0bIlHfW6ldHnvckBie3OjeR?= M4L2UVUh|ryP M3XqNFE3KGh? NXjudohMUW6qaXLpeIlwdiCxZjDQUWEue3SrbYXsZZRm\CCQRj3rZZBx[UJic3nncoFtcW6pIDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJG1FSS2PQj2yN|Eh[2WubIOgZZQhPSC3TTDpcoN2[mG2ZXSg[o9zKDF4IHjyd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYm= M3ribVI2OTlyNE[2
HL60 cells NG\SW4tRem:uaX\ldoF1cW:wIHHzd4F6 MnfqN|Ah|ryP NFO1S5Y1QCCq MkfURY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKTE[wJINmdGy|IHH0JFMxKHWPIHHmeIVzKDR6IHjyd{BjgSCPVGOgZZN{[Xl? Mom5NVgzPTh2NEC=

... Click to View More Cell Line Experimental Data

In vivo LD50: Mice >2500mg/kg (i.g.) [3]

Protocol

Solubility (25°C)

In vitro DMSO 57 mg/mL (199.13 mM)
Ethanol 3 mg/mL warmed (10.48 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 286.24
Formula

C15H10O6

CAS No. 491-70-3
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Molecular Weight Calculator

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02909686 Recruiting Gulf War Illness University of Alabama at Birmingham|Congressionally Directed Medical Research Programs July 2016 Phase 2
NCT01847521 Completed Autism Spectrum Disorders Attikon Hospital December 2011 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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PDE Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID