Luteolin

Catalog No.S2320

Luteolin Chemical Structure

Molecular Weight(MW): 286.24

Luteolin is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. Phase 2.

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In DMSO USD 70 In stock
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USD 570 In stock
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1 Customer Review

  • Bioactive compounds inhibit recombinant HDAC activity. Recombinant HDACs were incubated with flavonoid Luteolin (C) for 2 h prior to the addition of cell permeable HDAC substrates. Luteolin inhibited activity of most classes I, IIa, and IIb HDAC isoforms.

    Mol Nutr Food Res, 2017. Luteolin purchased from Selleck.

Purity & Quality Control

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Biological Activity

Description Luteolin is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. Phase 2.
Targets
PDE2 [1]
(Cell-free assay)
PDE5 [1]
(Cell-free assay)
PDE4 [1]
(Cell-free assay)
PDE3 [1]
(Cell-free assay)
PDE1 [1]
(Cell-free assay)
6.4 μM(Ki) 9.5 μM(Ki) 11.1 μM(Ki) 13.9 μM(Ki) 15.0 μM(Ki)
In vitro

Luteolin is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. [1] Luteolin inhibits LPS-stimulated TNF-alpha production with an IC50 of less than 1 μM. Luteolin inhibites LPS-induced phosphorylation of Akt as well as IkappaBalpha. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
mouse RAW264.7 cells M2PRN2Z2dmO2aX;uJIF{e2G7 MV[yJIg> M1uybGlvcGmkaYTpc44hd2ZiTl:gdJJw\HWldHnvckBqdiCOUGOtd5RqdXWuYYTl[EBud3W|ZTDSRXczPjRwNzDj[YxteyCycnWtbY5kfWKjdHXkJIZweiB{IHjyd{Bj\W[xcnWgUHBUKHO2aX31cIF1cW:wIH\vdkAzPCCqcoOgZpkhT3KrZYPzJIF{e2G7IH3leIhw\CxiSVO1NF0xNjJzIN88US=> NFHzRWkzPTF5NkG4Oy=>
HEK293 FS cells NHz0O4FHfW6ldHnvckBie3OjeR?= M2DOZWlvcGmkaYTpc44hd2ZiTl;YOEBmgHC{ZYPz[YQhcW5iSFXLNlk{KE[VIHPlcIx{KGG|c3Xzd4VlKGG|IFiyU|IheHKxZIXjeIlwdiCkeTDINm8zN1S7cj;MVG8h[XO|YYmsJGlEPTB;MD64OUDPxE1? MWqyNFc{OTN3Nx?=
CHO cells MU\GeY5kfGmxbjDhd5NigQ>? MUXB[49vcXO2IHHjeIl3cXS7IHH0JJJifCCGQWSg[ZhxemW|c3XkJIlvKEOKTzDj[YxteyxiRVO1NF0yNjR3IN88US=> MoHJNlA6PzF4NUC=
human MV4-11 cells MXjDfZRwfG:6aXPpeJkh[XO|YYm= MX63NkBp M3LEeWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1XPC1zMTDj[YxteyCqYYLic5JqdmdiRlzUN{BufXSjdHnvckBi\nSncjC3NkBpenNiYomgeIV1emG8b3zpeY0h[mG|ZXSgSZohS3mWb4igZ4VtdCC4aXHibYxqfHliYYPzZZktKEeLNUC9NU44PiEQvF2= NXK2cI1YOjN2MUGwO|M>
HEK293 cells Ml;3SpVv[3Srb36gZZN{[Xl? M1HDTlI1KGh? MlPwRYdwdmm|dDDhZ5Rqfmm2eTDheEBud3W|ZTDQVGFT\2GvbXGg[ZhxemW|c3XkJIlvKEiHS{K5N{Bk\WyuczDjc{1mgHC{ZYPzbY5oKHerdHigS4FtPCC{ZYDvdpRmeiC4ZXP0c5Ih[W[2ZYKgNlQhcHK|IHL5JIR2[WxvbIXjbYZmemG|ZTDy[ZBwenSncjDhd5NigSxiRVO1NF0zNjNizszN NF:0fFYzPDl3NUi4PS=>
human U2OS cells MmPxSpVv[3Srb36gZZN{[Xl? MVm1JIg> MmjpRYdwdmm|dDDhZ5Rqfmm2eTDheEBIWFJ|NTDy[YNmeHSxcjDpckBpfW2jbjDVNm9UKGOnbHzzJINw\XiycnXzd4lv\yCJYXy0MXZROTZvVFXWJIF{e2W|c3XkJIF{KGKndHGgZZJz\XO2aX6geJJidnOub3PheIlwdiCjZoTldkA2KGi{czDifUBj\XSjIHzhZ5RidWG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBGSzVyPUOuNkDPxE1? NX3jbGJrOjR7MEC0OFc>
RBL-2H3 cells MmjZSpVv[3Srb36gZZN{[Xl? NIjXOpRKdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QhUUxvNDDwdo9lfWO2aX;uJIlvKFKETD2yTFMh[2WubIOge4F{KGSndHXycYlv\WRuIFnDOVA:Oy55IN88US=> NGryXWgyOjl3MUC5Ni=>
human mast cells NFiyN4lHfW6ldHnvckBie3OjeR?= NWDQVYc4UW6qaXLpeIlwdiCxZjDTXWshcW5iaIXtZY4hdWG|dDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hdWG|dDDj[YxtKGSnZ4LhcpVt[XSrb36sJGVEPTB;ND61JO69VQ>? MXqyNlI2PzJzMx?=
human LNCAP cells NE\VfJdHfW6ldHnvckBie3OjeR?= NGDIV45Fd3ewcnXneYxifGmxbjDv[kBxem:|dHH0[UB{eGWlaX\pZ{BidnSrZ3XuJJNm[3KndHnvckBqdiCqdX3hckBNVkODUDDj[YxteyxiSVO1NF02KM7:TR?= NX3LeIxiOjVyMUm0O|g>
rat H9c2 cells MUnGeY5kfGmxbjDhd5NigQ>? M{LOc|I1KGh? MUjDfZRweHKxdHXjeIl3\SCjY4Tpeol1gSCjZ3HpcpN1KGSxeH;yeYJq[2mwLXnu[JVk\WRiY4n0c5RwgGmlaYT5JIlvKHKjdDDIPYMzKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IEK0JIhzeyCkeTDNWHQh[XO|YYmsJGVEPTB;NT61N{DPxE1? MV6yNFk{Ojd4Mh?=
human HT-29 cells Ml7lSpVv[3Srb36gZZN{[Xl? M33kSVExKG2rboO= MWPB[49vcXO2IHHjeIl3cXS7IHH0JGdRWjN3IILlZ4VxfG:{IHnuJIh2dWGwIFjUMVI6KGOnbHzzJIFnfGW{IEGwJI1qdnNiYomg[Jlv[W2rYzDtZZN{KHKnZHnzeJJq[nW2aX;uJIF{e2G7LDDFR|UxRTdwMkSg{txO NFT2WVYzPDlyMES0Oy=>
human RS4:11 cells M3PCZWN6fG:2b4jpZ4l1gSCjc4PhfS=> Ml3RO|IhcA>? NUXjcZdFS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWlN2OkGxJINmdGy|IHjhdoJwemmwZzD3bYxlKHS7cHWgSmxVOyCjZoTldkA4OiCqcoOgZpkhfGW2cnH6c4xqfW1iYnHz[YQhTXpiQ4nUc5gh[2WubDD2bYFjcWyrdImgZZN{[XluIFfJOVA:Py5{NTFOwG0> MonGNlM1OTFyN{O=
NCI-H460 cells MXjGeY5kfGmxbjDhd5NigQ>? NXz5OnhkOi1{MDDo NXfTfpY1UW6qaXLpeIlwdiCxZjDBRmNIOiCneIDy[ZN{\WRiaX6gbJVu[W5iTlPJMWg1PjBiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBRcEFiYXPjeY12dGG2aX;uJIFnfGW{IEKgeI8hOjBiaILzJJJmdGG2aY\lJJRwKG[3bXn0doVud3KpaX6gR{whUUN3ME24Mlkh|ryP MYKyNVI4PTN6Nh?=
human H9 cells NU\xe4NtTnWwY4Tpc44h[XO|YYm= MUKzJIRigXN? MUfBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYyKDOEIHnu[oVkfGWmIHnuJIh2dWGwIFi5JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwhemWybHnjZZRqd25iYX\0[ZIhOyCmYYnzJIJ6KHB{NDDhcpRq\2WwIHPhdJR2emViYYPzZZktKEWFNUC9NVAh|ryP MX64NVU5OTZ2
MDCK cells MmfZR5l1d3SxeHnjbZR6KGG|c3H5 MVXDfZRwfG:6aXPpeJkh[WejaX7zeEBOTEONIHPlcIx{KGK7IF3UWEBie3OjeTygR2M2OD1zMj60OEDPxE1? NVTsPIp3OTh4NECwOFI>
mouse B16-4A5 cells MmCwSpVv[3Srb36gZZN{[Xl? MVS3NkBp MW\Jcohq[mm2aX;uJI9nKHSqZX;wbJltdGmwZT3zeIlufWyjdHXkJI1mdGGwb3flcoV{cXNiaX6gcY92e2ViQkG2MVRCPSClZXzsd{Bi\nSncjC3NkBpenNuIFnDOVA:OTRizszN M{W5W|IxOTh7M{m5
K562 cells MWTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWi1JIRigXN? M2LocWdzd3e2aDDpcohq[mm2aX;uJI9nKEt3NkKgZ4VtdHNiYomgXHRVKGG|c3H5JIFnfGW{IEWg[IF6eyxiSVO1NF0yPC54NTFOwG0> M4HNe|E4PDFzMEmy
human H9 cells MYPDfZRwfG:6aXPpeJkh[XO|YYm= NEj3Xmo{KGSjeYO= NGDlV3dEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJQSClZXzsd{Bi\nSncjCzJIRigXNuIFnDOVA:OTZizszN NHLQTlM5OTV6MU[0
human HT-29 cells MnPhSpVv[3Srb36gZZN{[Xl? MYexNEBucW6| MXfE[ZNmdnOrdHn6ZZRqd25ib3[gS3BTOzVicnXj[ZB1d3JiaX6gbJVu[W5iSGStNlkh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD6ZZBzcW6jc4StbY5lfWOnZDDkfY5idWmlIH3hd5MhemWmaYP0doljfXSrb36gZYZ1\XJiMUCgcYlveyxiSVO1NF0yQC54IN88US=> M1HqPVI1QTByNES3
human U937 cells NWrwN3E{WHKxbHnm[ZJifGmxbjDhd5NigQ>? MkmxO|IhcA>? NHvqT3ZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGW5N|ch[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IGfTWE05KGG|c3H5MEBKSzVyPUKwJO69VQ>? Mlu1NVcyPThyNUS=
mouse HT22 cells M{fZNGZ2dmO2aX;uJIF{e2G7 NFXMXHc{KGh? MUPO[ZVzd3C{b4TlZ5RqfmViYXP0bZZqfHliaX6gcY92e2ViSGSyNkBk\WyuczDhd5Nme3OnZDDhd{B1NUKRT1itbY5lfWOnZDD0c5hq[2m2eTDheEA1OCC3TTDwdoVqdmO3YnH0[YQh\m:{IEOgbJJ{KG[xbHzve4VlKGK7IIStRm9QUCCrbnT1Z5Rqd25ibXXhd5Vz\WRiYX\0[ZIhQSCqcoOgZpkhVVSWIHHzd4F6 MmnzNlQzPDV7M{m=
human THP1 cells NWrH[YlMTnWwY4Tpc44h[XO|YYm= MmTDNlAh|ryP NVPoS|J[OSCq MoTMSI94dnKnZ4XsZZRqd25ib3[gWHBCNWmwZIXj[YQhVk:[MjDtVm5CKGW6cILld5Nqd25iaX6gbJVu[W5iVFjQNUBk\WyuczDheEAzOCC3TTDpcoN2[mG2ZXSg[o9zKDFiaIKgdJJqd3JidH:gWHBCKGOqYXzs[Y5o\SCvZXHzeZJm\CCjZoTldkAzPCCqcoOgZpkhWlRvUFPSJIFv[Wy7c3nz MoLINlM4QDZ3MkC=
MDA-MB-231 cells MoG1SpVv[3Srb36gZZN{[Xl? MXu1JO69VQ>? NXzBTmZFOTZiaB?= MkfWTY5pcWKrdHnvckBw\iCSTVGtd5RqdXWuYYTl[EBPTi2tYYDwZWIhe2mpbnHsbY5oKCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIF3ERU1OSi1{M{GgZ4VtdHNiYYSgOUB2VSCrbnP1ZoF1\WRiZn;yJFE3KGi{czDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[Xl? MVyyOVE6ODR4Nh?=
HL60 cells M4jGNnBzd2yrZnXyZZRqd25iYYPzZZk> M2TBR|MxKM7:TR?= MnLzOFghcA>? MlTaRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKTE[wJINmdGy|IHH0JFMxKHWPIHHmeIVzKDR6IHjyd{BjgSCPVGOgZZN{[Xl? NVvxc4lOOTh{NUi0OFA>

... Click to View More Cell Line Experimental Data

In vivo LD50: Mice >2500mg/kg (i.g.) [3]

Protocol

Solubility (25°C)

In vitro DMSO 57 mg/mL (199.13 mM)
Ethanol 3 mg/mL warmed (10.48 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 286.24
Formula

C15H10O6

CAS No. 491-70-3
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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The Serial Dilution Calculator Equation

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02909686 Recruiting Gulf War Illness University of Alabama at Birmingham|Congressionally Directed Medical Research Programs July 2016 Phase 2
NCT01847521 Completed Autism Spectrum Disorders Attikon Hospital December 2011 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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PDE Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID