Luteolin

Catalog No.S2320

Luteolin Chemical Structure

Molecular Weight(MW): 286.24

Luteolin is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. Phase 2.

Size Price Stock Quantity  
In DMSO USD 70 In stock
USD 50 In stock
USD 170 In stock
USD 570 In stock
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1 Customer Review

  • Bioactive compounds inhibit recombinant HDAC activity. Recombinant HDACs were incubated with flavonoid Luteolin (C) for 2 h prior to the addition of cell permeable HDAC substrates. Luteolin inhibited activity of most classes I, IIa, and IIb HDAC isoforms.

    Mol Nutr Food Res, 2017. Luteolin purchased from Selleck.

Purity & Quality Control

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Biological Activity

Description Luteolin is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. Phase 2.
Targets
PDE2 [1]
(Cell-free assay)
PDE5 [1]
(Cell-free assay)
PDE4 [1]
(Cell-free assay)
PDE3 [1]
(Cell-free assay)
PDE1 [1]
(Cell-free assay)
6.4 μM(Ki) 9.5 μM(Ki) 11.1 μM(Ki) 13.9 μM(Ki) 15.0 μM(Ki)
In vitro

Luteolin is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. [1] Luteolin inhibits LPS-stimulated TNF-alpha production with an IC50 of less than 1 μM. Luteolin inhibites LPS-induced phosphorylation of Akt as well as IkappaBalpha. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
mouse RAW264.7 cells NEjuenpHfW6ldHnvckBie3OjeR?= M{fWelIhcA>? MmezTY5pcWKrdHnvckBw\iCQTzDwdo9lfWO2aX;uJIlvKEySUz3zeIlufWyjdHXkJI1wfXOnIGLBW|I3PC55IHPlcIx{KHC{ZT3pcoN2[mG2ZXSg[o9zKDJiaILzJIJm\m:{ZTDMVHMhe3SrbYXsZZRqd25iZn;yJFI1KGi{czDifUBIemmnc4OgZZN{[XlibXX0bI9lNCCLQ{WwQVAvOjFizszN NV7ydWRxOjVzN{[xPFc>
HEK293 FS cells M{DyfGZ2dmO2aX;uJIF{e2G7 MWjJcohq[mm2aX;uJI9nKE6RWESg[ZhxemW|c3XkJIlvKEiHS{K5N{BHWyClZXzsd{Bie3Onc4Pl[EBieyCKMl:yJJBzd2S3Y4Tpc44h[nliSELPNk9VgXJxTGDPJIF{e2G7LDDJR|UxRTBwOEWg{txO NXjCZlFwOjB5M{GzOVc>
CHO cells NUKzc|VCTnWwY4Tpc44h[XO|YYm= M1T3R2Fod26rc4SgZYN1cX[rdImgZZQhemG2IFTBWEBmgHC{ZYPz[YQhcW5iQ1jPJINmdGy|LDDFR|UxRTFwNEWg{txO M{fsWFIxQTdzNkWw
human MV4-11 cells MW\DfZRwfG:6aXPpeJkh[XO|YYm= MWS3NkBp MYnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNWlQuOTFiY3XscJMhcGG{Yn;ybY5oKE[OVEOgcZV1[XSrb36gZYZ1\XJiN{KgbJJ{KGK7IITleJJigm:uaYXtJIJie2WmIFX6JGN6XG:6IHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBIUTVyPUGuO|Yh|ryP M1riflI{PDFzMEez
HEK293 cells NHmyV2RHfW6ldHnvckBie3OjeR?= MUOyOEBp MlixRYdwdmm|dDDhZ5Rqfmm2eTDheEBud3W|ZTDQVGFT\2GvbXGg[ZhxemW|c3XkJIlvKEiHS{K5N{Bk\WyuczDjc{1mgHC{ZYPzbY5oKHerdHigS4FtPCC{ZYDvdpRmeiC4ZXP0c5Ih[W[2ZYKgNlQhcHK|IHL5JIR2[WxvbIXjbYZmemG|ZTDy[ZBwenSncjDhd5NigSxiRVO1NF0zNjNizszN NILHS3AzPDl3NUi4PS=>
human U2OS cells MoLoSpVv[3Srb36gZZN{[Xl? NUS0[opWPSCq MXXB[49vcXO2IHHjeIl3cXS7IHH0JGdRWjN3IILlZ4VxfG:{IHnuJIh2dWGwIGWyU3Mh[2WubIOgZ49mgHC{ZYPzbY5oKEejbEStWnAyPi2WRW[gZZN{\XO|ZXSgZZMh[mW2YTDhdpJme3SrbjD0doFve2yxY3H0bY9vKGGodHXyJFUhcHK|IHL5JIJmfGFibHHjeIFu[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTB;Mz6yJO69VQ>? NHTv[m0zPDlyMES0Oy=>
RBL-2H3 cells NWeyeVQ2TnWwY4Tpc44h[XO|YYm= MmPZTY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JGlNNTRicILv[JVkfGmxbjDpckBTSkxvMlizJINmdGy|IIfhd{Bl\XSncn3pcoVlNCCLQ{WwQVMvPyEQvF2= NXnObJRnOTJ7NUGwPVI>
human mast cells Ml\0SpVv[3Srb36gZZN{[Xl? M1HhbGlvcGmkaYTpc44hd2ZiU2nLJIlvKGi3bXHuJI1ie3RiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJI1ie3RiY3XscEBl\We{YX71cIF1cW:wLDDFR|UxRTRwNTFOwG0> NHvu[FczOjJ3N{KxNy=>
human LNCAP cells NWfKems5TnWwY4Tpc44h[XO|YYm= NV7KUlRsTG:5boLl[5Vt[XSrb36gc4YheHKxc4TheIUhe3CnY3nmbYMh[W62aXflckB{\WO{ZYTpc44hcW5iaIXtZY4hVE6FQWCgZ4VtdHNuIFnDOVA:PSEQvF2= MnjhNlUxOTl2N{i=
rat H9c2 cells NEX1XlJHfW6ldHnvckBie3OjeR?= MVSyOEBp MVvDfZRweHKxdHXjeIl3\SCjY4Tpeol1gSCjZ3HpcpN1KGSxeH;yeYJq[2mwLXnu[JVk\WRiY4n0c5RwgGmlaYT5JIlvKHKjdDDIPYMzKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IEK0JIhzeyCkeTDNWHQh[XO|YYmsJGVEPTB;NT61N{DPxE1? NI[4fYQzODl|Mke2Ni=>
human HT-29 cells NIK5c3hHfW6ldHnvckBie3OjeR?= NWjtNFYzOTBibXnudy=> NGHhPJdC\2:waYP0JIFkfGm4aYT5JIF1KEeSUkO1JJJm[2WydH;yJIlvKGi3bXHuJGhVNTJ7IHPlcIx{KGGodHXyJFExKG2rboOgZpkh\HmwYX3pZ{Bu[XO|IILl[Il{fHKrYoX0bY9vKGG|c3H5MEBGSzVyPUeuNlQh|ryP NH;rdFIzPDlyMES0Oy=>
human RS4:11 cells NH;weGREgXSxdH;4bYNqfHliYYPzZZk> NW[xW5JKPzJiaB?= Ml;NR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVnM1QjFzIHPlcIx{KGijcnLvdolv\yC5aXzkJJR6eGViRlzUN{Bi\nSncjC3NkBpenNiYomgeIV1emG8b3zpeY0h[mG|ZXSgSZohS3mWb4igZ4VtdCC4aXHibYxqfHliYYPzZZktKEeLNUC9O{4zPSEQvF2= M{HNe|I{PDFzMEez
NCI-H460 cells MoHGSpVv[3Srb36gZZN{[Xl? M{PJcVIuOjBiaB?= NFzJT4tKdmirYnn0bY9vKG:oIFHCR2czKGW6cILld5Nm\CCrbjDoeY1idiCQQ1mtTFQ3OCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJHBpSSCjY3P1cZVt[XSrb36gZYZ1\XJiMjD0c{AzOCCqcoOgdoVt[XSrdnWgeI8h\nWvaYTy[Y1wemerbjDDMEBKSzVyPUiuPUDPxE1? NWTmUHhkOjF{N{WzPFY>
human H9 cells MY\GeY5kfGmxbjDhd5NigQ>? MY[zJIRigXN? MnX1RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXOSB|QjDpcoZm[3SnZDDpckBpfW2jbjDIPUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdoFtKHKncHzpZ4F1cW:wIHHmeIVzKDNiZHH5d{BjgSCyMkSgZY51cWenbjDjZZB1fXKnIHHzd4F6NCCHQ{WwQVExKM7:TR?= NYrRcI5uQDF3OEG2OC=>
MDCK cells MojZR5l1d3SxeHnjbZR6KGG|c3H5 MWfDfZRwfG:6aXPpeJkh[WejaX7zeEBOTEONIHPlcIx{KGK7IF3UWEBie3OjeTygR2M2OD1zMj60OEDPxE1? MW[xPFY1ODB2Mh?=
mouse B16-4A5 cells M3vlbGZ2dmO2aX;uJIF{e2G7 NYHaNGg3PzJiaB?= M17qO2lvcGmkaYTpc44hd2ZidHjlc5BpgWyuaX7lMZN1cW23bHH0[YQhdWWuYX7v[4Vv\XOrczDpckBud3W|ZTDCNVYuPEF3IHPlcIx{KGGodHXyJFczKGi{czygTWM2OD1zNDFOwG0> MYCyNFE5QTN7OR?=
K562 cells NHPYOYhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWWzcFA5PSCmYYnz NIjqNotIem:5dHigbY5pcWKrdHnvckBw\iCNNU[yJINmdGy|IHL5JHhVXCCjc4PhfUBi\nSncjC1JIRigXNuIFnDOVA:OTRwNkWg{txO M4P3eFE4PDFzMEmy
human H9 cells M13t[2N6fG:2b4jpZ4l1gSCjc4PhfS=> NWT1fW5rOyCmYYnz M1ewO2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGg6KGOnbHzzJIFnfGW{IEOg[IF6eyxiSVO1NF0yPiEQvF2= M1SyV|gyPThzNkS=
human HT-29 cells NHq2cndHfW6ldHnvckBie3OjeR?= M1HWU|ExKG2rboO= NYSyTotUTGW|ZX7zbZRqgmG2aX;uJI9nKEeSUkO1JJJm[2WydH;yJIlvKGi3bXHuJGhVNTJ7IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhgmGycnnuZZN1NWmwZIXj[YQh\HmwYX3pZ{Bu[XO|IILl[Il{fHKrYoX0bY9vKGGodHXyJFExKG2rboOsJGlEPTB;MUiuOkDPxE1? MUWyOFkxODR2Nx?=
human U937 cells MXvQdo9tcW[ncnH0bY9vKGG|c3H5 M3\uflczKGh? NX;hZY5ESW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDVPVM4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDXV3QuQCCjc4PhfUwhUUN3ME2yNEDPxE1? Mm[3NVcyPThyNUS=
mouse HT22 cells NHHEUJdHfW6ldHnvckBie3OjeR?= NWrrOoo{OyCq MX7O[ZVzd3C{b4TlZ5RqfmViYXP0bZZqfHliaX6gcY92e2ViSGSyNkBk\WyuczDhd5Nme3OnZDDhd{B1NUKRT1itbY5lfWOnZDD0c5hq[2m2eTDheEA1OCC3TTDwdoVqdmO3YnH0[YQh\m:{IEOgbJJ{KG[xbHzve4VlKGK7IIStRm9QUCCrbnT1Z5Rqd25ibXXhd5Vz\WRiYX\0[ZIhQSCqcoOgZpkhVVSWIHHzd4F6 NVrnPYtoOjR{NEW5N|k>
human THP1 cells M2LScWZ2dmO2aX;uJIF{e2G7 MY[yNEDPxE1? Mn;jNUBp M1jhS2Rwf26{ZXf1cIF1cW:wIH;mJHRRSS2rbnT1Z4VlKE6RWEKgcXJPSSCneIDy[ZN{cW:wIHnuJIh2dWGwIGTIVFEh[2WubIOgZZQhOjBidV2gbY5kfWKjdHXkJIZweiBzIHjyJJBzcW:{IITvJHRRSSClaHHscIVv\2VibXXhd5Vz\WRiYX\0[ZIhOjRiaILzJIJ6KFKWLWDDVkBidmGueYPpdy=> NFHHRYkzOzd6NkWyNC=>
MDA-MB-231 cells MYnGeY5kfGmxbjDhd5NigQ>? NFPhNXg2KM7:TR?= Mn7zNVYhcA>? NI\MU|RKdmirYnn0bY9vKG:oIGDNRU1{fGmvdXzheIVlKE6ILXvhdJBiSiC|aXfuZYxqdmdiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gUWRCNU2ELUKzNUBk\WyuczDheEA2KHWPIHnuZ5Vj[XSnZDDmc5IhOTZiaILzJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeR?= MWqyOVE6ODR4Nh?=
HL60 cells M4qy[XBzd2yrZnXyZZRqd25iYYPzZZk> NFW4S4g{OCEQvF2= Ml\IOFghcA>? NHvsboFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjMOlAh[2WubIOgZZQhOzBidV2gZYZ1\XJiNEigbJJ{KGK7IF3UV{Bie3OjeR?= M2jPRVE5OjV6NESw

... Click to View More Cell Line Experimental Data

In vivo LD50: Mice >2500mg/kg (i.g.) [3]

Protocol

Solubility (25°C)

In vitro DMSO 57 mg/mL (199.13 mM)
Ethanol 3 mg/mL warmed (10.48 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 286.24
Formula

C15H10O6

CAS No. 491-70-3
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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The Serial Dilution Calculator Equation

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02909686 Recruiting Gulf War Illness University of Alabama at Birmingham|Congressionally Directed Medical Research Programs July 2016 Phase 2
NCT01847521 Completed Autism Spectrum Disorders Attikon Hospital December 2011 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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PDE Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID