Luteolin

Catalog No.S2320

Luteolin Chemical Structure

Molecular Weight(MW): 286.24

Luteolin is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. Phase 2.

Size Price Stock Quantity  
In DMSO USD 70 In stock
USD 50 In stock
USD 170 In stock
USD 570 In stock
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1 Customer Review

  • Bioactive compounds inhibit recombinant HDAC activity. Recombinant HDACs were incubated with flavonoid Luteolin (C) for 2 h prior to the addition of cell permeable HDAC substrates. Luteolin inhibited activity of most classes I, IIa, and IIb HDAC isoforms.

    Mol Nutr Food Res, 2017. Luteolin purchased from Selleck.

Purity & Quality Control

Choose Selective PDE Inhibitors

Biological Activity

Description Luteolin is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. Phase 2.
Targets
PDE2 [1]
(Cell-free assay)
PDE5 [1]
(Cell-free assay)
PDE4 [1]
(Cell-free assay)
PDE3 [1]
(Cell-free assay)
PDE1 [1]
(Cell-free assay)
6.4 μM(Ki) 9.5 μM(Ki) 11.1 μM(Ki) 13.9 μM(Ki) 15.0 μM(Ki)
In vitro

Luteolin is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. [1] Luteolin inhibits LPS-stimulated TNF-alpha production with an IC50 of less than 1 μM. Luteolin inhibites LPS-induced phosphorylation of Akt as well as IkappaBalpha. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
mouse RAW264.7 cells M{fwUmZ2dmO2aX;uJIF{e2G7 MnPLNkBp NFnlPGhKdmirYnn0bY9vKG:oIF7PJJBzd2S3Y4Tpc44hcW5iTGDTMZN1cW23bHH0[YQhdW:3c3WgVmFYOjZ2LkegZ4VtdHNicILlMYlv[3WkYYTl[EBnd3JiMjDodpMh[mWob4LlJGxRWyC|dHnteYxifGmxbjDmc5IhOjRiaILzJIJ6KEe{aXXzd{Bie3OjeTDt[ZRpd2RuIFnDOVA:OC5{MTFOwG0> NHH0VoMzPTF5NkG4Oy=>
HEK293 FS cells MUjGeY5kfGmxbjDhd5NigQ>? M4HOe2lvcGmkaYTpc44hd2ZiTl;YOEBmgHC{ZYPz[YQhcW5iSFXLNlk{KE[VIHPlcIx{KGG|c3Xzd4VlKGG|IFiyU|IheHKxZIXjeIlwdiCkeTDINm8zN1S7cj;MVG8h[XO|YYmsJGlEPTB;MD64OUDPxE1? MVyyNFc{OTN3Nx?=
CHO cells M3;rdWZ2dmO2aX;uJIF{e2G7 MX3B[49vcXO2IHHjeIl3cXS7IHH0JJJifCCGQWSg[ZhxemW|c3XkJIlvKEOKTzDj[YxteyxiRVO1NF0yNjR3IN88US=> Ml33NlA6PzF4NUC=
human MV4-11 cells Mo\LR5l1d3SxeHnjbZR6KGG|c3H5 NF7xVYs4OiCq Mmq5R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUXY1NTFzIHPlcIx{KGijcnLvdolv\yCITGSzJI12fGG2aX;uJIFnfGW{IEeyJIhzeyCkeTD0[ZRz[XqxbHn1cUBj[XOnZDDFfkBEgVSxeDDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhT0l3ME2xMlc3KM7:TR?= NIn3SFkzOzRzMUC3Ny=>
HEK293 cells M2L0OWZ2dmO2aX;uJIF{e2G7 NHXEbVUzPCCq MWrB[49vcXO2IHHjeIl3cXS7IHH0JI1wfXOnIGDQRXJo[W2vYTDlfJBz\XO|ZXSgbY4hUEWNMkmzJINmdGy|IHPvMYV5eHKnc4Ppcochf2m2aDDHZYw1KHKncH;yeIVzKH[nY4TvdkBi\nSncjCyOEBpenNiYomg[JVidC2udXPp[oVz[XOnIILldI9zfGW{IHHzd4F6NCCHQ{WwQVIvOyEQvF2= NYLtPYVrOjR7NUW4PFk>
human U2OS cells NEfkdXVHfW6ldHnvckBie3OjeR?= NXK3PXZvPSCq M4HLOGFod26rc4SgZYN1cX[rdImgZZQhT1CUM{WgdoVk\XC2b4KgbY4hcHWvYX6gWVJQWyClZXzsd{Bkd2W6cILld5NqdmdiR3HsOE1XWDF4LWTFWkBie3Onc4Pl[EBieyCkZYThJIFzemW|dHnuJJRz[W6|bH;jZZRqd25iYX\0[ZIhPSCqcoOgZpkh[mW2YTDsZYN1[W2jc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3ME2zMlIh|ryP MlLTNlQ6ODB2NEe=
RBL-2H3 cells MXXGeY5kfGmxbjDhd5NigQ>? MUTJcohq[mm2b4L5JIFkfGm4aYT5JIFo[Wmwc4SgTWwuPCCycn;keYN1cW:wIHnuJHJDVC1{SEOgZ4VtdHNid3HzJIRmfGW{bXnu[YQtKEmFNUC9N{44KM7:TR?= M2S3dFEzQTVzMEmy
human mast cells NX2xVWZETnWwY4Tpc44h[XO|YYm= Mlf0TY5pcWKrdHnvckBw\iCVWVugbY4hcHWvYX6gcYF{fCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gcYF{fCClZXzsJIRm\3KjboXsZZRqd25uIFXDOVA:PC53IN88US=> NHrINVQzOjJ3N{KxNy=>
human LNCAP cells M33MbmZ2dmO2aX;uJIF{e2G7 NIX2eFlFd3ewcnXneYxifGmxbjDv[kBxem:|dHH0[UB{eGWlaX\pZ{BidnSrZ3XuJJNm[3KndHnvckBqdiCqdX3hckBNVkODUDDj[YxteyxiSVO1NF02KM7:TR?= M4L2c|I2ODF7NEe4
rat H9c2 cells NXXrUmxzTnWwY4Tpc44h[XO|YYm= NVjMc3JROjRiaB?= MXHDfZRweHKxdHXjeIl3\SCjY4Tpeol1gSCjZ3HpcpN1KGSxeH;yeYJq[2mwLXnu[JVk\WRiY4n0c5RwgGmlaYT5JIlvKHKjdDDIPYMzKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IEK0JIhzeyCkeTDNWHQh[XO|YYmsJGVEPTB;NT61N{DPxE1? MnftNlA6OzJ5NkK=
human HT-29 cells M{jMfWZ2dmO2aX;uJIF{e2G7 M{jn[VExKG2rboO= M3yxR2Fod26rc4SgZYN1cX[rdImgZZQhT1CUM{WgdoVk\XC2b4KgbY4hcHWvYX6gTHQuOjliY3XscJMh[W[2ZYKgNVAhdWmwczDifUBlgW6jbXnjJI1ie3NicnXkbZN1emmkdYTpc44h[XO|YYmsJGVEPTB;Nz6yOEDPxE1? MWKyOFkxODR2Nx?=
human RS4:11 cells Mmj3R5l1d3SxeHnjbZR6KGG|c3H5 MmPxO|IhcA>? MUDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDSV|Q7OTFiY3XscJMhcGG{Yn;ybY5oKHerbHSgeJlx\SCITGSzJIFnfGW{IEeyJIhzeyCkeTD0[ZRz[XqxbHn1cUBj[XOnZDDFfkBEgVSxeDDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhT0l3ME23MlI2KM7:TR?= M3TmR|I{PDFzMEez
NCI-H460 cells NEf2NlJHfW6ldHnvckBie3OjeR?= MX2yMVIxKGh? NXu3cIQ4UW6qaXLpeIlwdiCxZjDBRmNIOiCneIDy[ZN{\WRiaX6gbJVu[W5iTlPJMWg1PjBiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBRcEFiYXPjeY12dGG2aX;uJIFnfGW{IEKgeI8hOjBiaILzJJJmdGG2aY\lJJRwKG[3bXn0doVud3KpaX6gR{whUUN3ME24Mlkh|ryP MYWyNVI4PTN6Nh?=
human H9 cells MUHGeY5kfGmxbjDhd5NigQ>? M3jIN|Mh\GG7cx?= NWXufHFISW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYMTCzRkBqdm[nY4Tl[EBqdiCqdX3hckBJQSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqemGuIILldIxq[2G2aX;uJIFnfGW{IEOg[IF6eyCkeTDwNlQh[W62aXflckBk[XC2dYLlJIF{e2G7LDDFR|UxRTFyIN88US=> MYG4NVU5OTZ2
MDCK cells NV7ZRVA{S3m2b4TvfIlkcXS7IHHzd4F6 M3L1NWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KE2GQ1ugZ4VtdHNiYomgUXRVKGG|c3H5MEBESzVyPUGyMlQ1KM7:TR?= MV:xPFY1ODB2Mh?=
mouse B16-4A5 cells Mo\pSpVv[3Srb36gZZN{[Xl? M3XHXlczKGh? MV;Jcohq[mm2aX;uJI9nKHSqZX;wbJltdGmwZT3zeIlufWyjdHXkJI1mdGGwb3flcoV{cXNiaX6gcY92e2ViQkG2MVRCPSClZXzsd{Bi\nSncjC3NkBpenNuIFnDOVA:OTRizszN MlfhNlAyQDl|OUm=
K562 cells NWX2bHBlT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3XtNFUh\GG7cx?= Mkj0S5Jwf3SqIHnubIljcXSrb36gc4YhUzV4MjDj[YxteyCkeTDYWHQh[XO|YYmgZYZ1\XJiNTDkZZl{NCCLQ{WwQVE1NjZ3IN88US=> M2\nVFE4PDFzMEmy
human H9 cells M1r0PWN6fG:2b4jpZ4l1gSCjc4PhfS=> M33GNFMh\GG7cx?= MkjSR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTFkh[2WubIOgZYZ1\XJiMzDkZZl{NCCLQ{WwQVE3KM7:TR?= MYq4NVU5OTZ2
human HT-29 cells M1TG[2Z2dmO2aX;uJIF{e2G7 MUmxNEBucW6| NECxW49F\XOnboPpeIl7[XSrb36gc4YhT1CUM{WgdoVk\XC2b4KgbY4hcHWvYX6gTHQuOjliY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB7[XC{aX7hd5QucW6mdXPl[EBlgW6jbXnjJI1ie3NicnXkbZN1emmkdYTpc44h[W[2ZYKgNVAhdWmwczygTWM2OD1zOD62JO69VQ>? NYPjOJJvOjR7MEC0OFc>
human U937 cells Mo\0VJJwdGmoZYLheIlwdiCjc4PhfS=> NFXuboE4OiCq NEOybGNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGW5N|ch[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IGfTWE05KGG|c3H5MEBKSzVyPUKwJO69VQ>? MV6xO|E2QDB3NB?=
mouse HT22 cells NGO5coJHfW6ldHnvckBie3OjeR?= M2jp[|MhcA>? M{XleG5mfXKxcILveIVkfGm4ZTDhZ5Rqfmm2eTDpckBud3W|ZTDIWFIzKGOnbHzzJIF{e2W|c3XkJIF{KHRvQl;PTE1qdmS3Y3XkJJRwgGmlaYT5JIF1KDRyIIXNJJBz\WmwY4XiZZRm\CCob4KgN{BpenNiZn;scI94\WRiYomgeE1DV0:KIHnu[JVkfGmxbjDt[YF{fXKnZDDh[pRmeiB7IHjyd{BjgSCPVGSgZZN{[Xl? NEHMfYozPDJ2NUmzPS=>
human THP1 cells MkDwSpVv[3Srb36gZZN{[Xl? MkH1NlAh|ryP NInlfGYyKGh? NGfPVHhFd3ewcnXneYxifGmxbjDv[kBVWEFvaX7keYNm\CCQT2iyJI1TVkFiZYjwdoV{e2mxbjDpckBpfW2jbjDUTHAyKGOnbHzzJIF1KDJyIIXNJIlv[3WkYYTl[EBnd3JiMTDodkBxemmxcjD0c{BVWEFiY3jhcIxmdmenIH3lZZN2emWmIHHmeIVzKDJ2IHjyd{BjgSCUVD3QR3Ih[W6jbInzbZM> MlfFNlM4QDZ3MkC=
MDA-MB-231 cells MWrGeY5kfGmxbjDhd5NigQ>? M1nBWFUh|ryP M2fXOlE3KGh? M{mwd2lvcGmkaYTpc44hd2ZiUF3BMZN1cW23bHH0[YQhVkZva3HwdIFDKHOrZ37hcIlv\yBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDNSGEuVUJvMkOxJINmdGy|IHH0JFUhfU1iaX7jeYJifGWmIH\vdkAyPiCqcoOgZpkhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7 NYnRTXkzOjVzOUC0OlY>
HL60 cells Moj1VJJwdGmoZYLheIlwdiCjc4PhfS=> MmDNN|Ah|ryP Mn;vOFghcA>? NUXVe4d2SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIUFYxKGOnbHzzJIF1KDNyIIXNJIFnfGW{IES4JIhzeyCkeTDNWHMh[XO|YYm= MoHaNVgzPTh2NEC=

... Click to View More Cell Line Experimental Data

In vivo LD50: Mice >2500mg/kg (i.g.) [3]

Protocol

Solubility (25°C)

In vitro DMSO 57 mg/mL (199.13 mM)
Ethanol 3 mg/mL warmed (10.48 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 286.24
Formula

C15H10O6

CAS No. 491-70-3
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Molecular Weight Calculator

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02909686 Recruiting Gulf War Illness University of Alabama at Birmingham|Congressionally Directed Medical Research Programs July 2016 Phase 2
NCT01847521 Completed Autism Spectrum Disorders Attikon Hospital December 2011 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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PDE Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID