Research Area
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United States ( Change Country )
Letrozole Chemical Structure
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Biological Activity
CGS 20267 maximally inhibits estradiol production in vitro in LH-stimulated hamster ovarian tissue at 0.1 μM with an IC50 of 0.02 μM and does not significantly affect progesterone production up to 350 μM. In ACTH-stimulated rat adrenal tissue in vitro, aldosterone production was inhibited with an IC50 of 210 μM (10,000 times higher than the IC50 for estradiol production); no significant effect on corticosterone production was seen at 350 μM. In vivo, in ACTH-treated rats, CGS 20267 does not affect plasma levels of corticosterone or aldosterone at a dose of 4 mg/kg p.o. (1000 times higher than the ED50 for aromatase inhibition in vivo) [1]
Inhibitory concentrations of letrozole against the aromatase enzyme derived from various cellular and non-cellular sources.
IC50 values: Human placental microsomes 11nM, MCF-7Ca cancer cells 0.07 nM, JEG-3 cancer cells 0.07 nM, Hamster Ovarian tissue 20 nM. [2]
References on Letrozole
- [] J. Steroid Bioehem. Molee. Biol 1990 ;37:1021-102
- [] Breast Cancer Res Treat 2007;105:7–17
Chemical Information
| Molecular Weight (WM): | 285.3 |
|---|---|
| Formula: | C17H11N5 |
| CAS No.: | 112809-51-5 |
| Synonyms: |
Femara, Piroxicam
|
| Dissolve in (25°C): | DMSO ≥57mg/mL |
| Water <1mg/mL | |
| Ethanol ≥5mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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