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Ispinesib (SB-715992) Chemical Structure
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Biological Activity
Ispinesib (SB 715992) is a potent mitotic kinesin KSP (Eg5) inhibitor with a Ki and an IC50 of 0.6 and 4.1 nM, respectively. Ispinesib (SB 715992) has cytotoxic activity at less than 10 nM in a spectrum of tumor cell lines. Ispinesib (SB 715992) is negative in a mouse model of peripheral neuropathy in which paclitaxel is positive. Ispinesib (SB 715992) was shown to have activity against advanced human colon tumor xenografts including: Colo205 (complete regressions), Colo201 (complete regressions), and HT-29 (tumor growth delay). Ispinesib (SB 715992) (10 mg/kg) induced unexplained toxicity in mice bearing osteosarcoma xenografts. Ispinesib (SB 715992) enhanced the antitumor activity of trastuzumab, lapatinib, doxorubicin, and capecitabine and exhibited activity comparable with paclitaxel and ixabepilone. [1][2]
References on Ispinesib (SB-715992)
- [1] Pediatr Blood Cancer. 2009 Dec 15;53(7):1255-63.
- [2] Clin Cancer Res 2010;16:566-576
Chemical Information
| Molecular Weight (WM): | 517.06 |
|---|---|
| Formula: | C30H33ClN4O2 |
| CAS No.: | 336113-53-2 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥103mg/mL |
| Water <1mg/mL | |
| Ethanol ≥103mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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