Imatinib (STI571)

Catalog No.S2475 Synonyms: CGP057148B, ST-1571

Imatinib (STI571) Chemical Structure

Molecular Weight(MW): 493.6

Imatinib (STI571) is a multi-target inhibitor of tyrosine kinase with inhibition for v-Abl, c-Kit and PDGFR, IC50 values are 0.6 μM, 0.1 μM and 0.1 μM in cell-free or cell-based assays, respectively.

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Cited by 35 Publications

6 Customer Reviews

  • Ba/F3-p210T315I cells were treated with indicated concentrations of imatinib with or without PDMP for 24 h. Apoptosis was determined as in A. Data are shown as percentage of sub-G1 for apoptosis in triplicate cultures. *P<0.05.

    FASEB J 2011 25, 3661-3673. Imatinib (STI571) purchased from Selleck.

    Targeting KITLG through c-KIT inhibition using Imatinib; one representative experiment is shown (n = 4).

    Oncotarget, 2016, 7(34):54583-54595. Imatinib (STI571) purchased from Selleck.


    Inhibition of thymidine (a and b) and cytarabine (c and d) uptake with imatinib. K562 cells (a and c) and MEG-01 cells (b and d) were incubated at 37 ◦C for 15 min with imatinib transport buffer, and then incubated with 0.5 Ci of [3H] thymidine or [3H] cytarabine for an additional 5 min in presence of imatinib. Cells were then washed 3 times, lysed and radioactivity associated to cell pellets was quantified. DMSO, dimethylsulfoxide; DPD, dipyridamole.

    Leukemia Res 2012 36, 1311-1314. Imatinib (STI571) purchased from Selleck.

    ZFX regulates imatinib sensitivity and PI3K/Akt signaling pathway in CML cells. Viability of cells transfected with si-ZFX at the indicated doses of imatinib for 24 h (a). Colonies of leukemia cells and imatinib-resistant cells transfected with si-ZFX following treatment with imatinib for 10 days (b). Western blot analysis of Akt, p-Akt, CyclinD1, CyclinE1, Bcl-2, and Caspase-3 in K562 and K562/G01 cells transfected with si-ZFX for 2 days (c). The relative densities of proteins were quantified and normalized to b-Actin (d). Values represented the mean ± SD data from experiments in triplicate. *P\0.05 and **P\0.01

    Cell Biochem Biophys, 2016, 74(2):277-83. Imatinib (STI571) purchased from Selleck.

  • Cell Viability assay results. A2C12, BetaD5, GammaA3, GammaD12, A549, CaCo2, HepG2 cell lines were treated with imatinib mesylate for 24h and 96h.

    Dr. Thomas Kruwel of Fraunhofer. Imatinib (STI571) purchased from Selleck.

    A. Viability curve for the c-Kit mutant MelMS melanoma cell line treated with increasing concentrations of imatinib for 72h (relative to DMSO-treated controls; mean ±sd; n=3) B. MelMS melanoma cells were treated with 50nM imatinib for 24h. The effects on c-Kit, ERK and AKT activation were determined by immunoblotting.

    Dr. Helen Rizos from the university of Sydney. Imatinib (STI571) purchased from Selleck.

Purity & Quality Control

Choose Selective PDGFR Inhibitors

Biological Activity

Description Imatinib (STI571) is a multi-target inhibitor of tyrosine kinase with inhibition for v-Abl, c-Kit and PDGFR, IC50 values are 0.6 μM, 0.1 μM and 0.1 μM in cell-free or cell-based assays, respectively.
(Cell-free assay)
c-Kit [2]
(M-07e cells)
v-Abl [1]
(Cell-free assay)
100 nM 100 nM 600 nM
In vitro

In vitro assays for inhibition of a panel of tyrosine and serine/threonine protein kinases show that Imatinib inhibits the v-Abl tyrosine kinase and PDGFR potently with an IC50 of 0.6 and 0.1 μM, respectively. [1] Imatinib inhibits the SLF-dependent activation of wild-type c-kit kinase activity with a IC50 for these effects of approximately 0.1 μM, which is similar to the concentration required for inhibition of PDGFR. [2] Imatinib exhibits growth-inhibitory activity on the human bronchial carcinoid cell line NCI-H727 and the human pancreatic carcinoid cell line BON-1 with an IC50 of 32.4 and 32.8 μM, respectively. [3] A recent study shows that Imatinib has the potential to exert its antileukemia effects in chronic myelogenous leukemia by down-regulating hERG1 K(+) channels, which are highly expressed in leukemia cells and appear of exceptional importance in favoring leukemogenesis. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EM-2 MnPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWL4b29RUUN3ME2wMlA5QDhizszN MVTTRW5ITVJ?
MEG-01 MnqxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHz5ZYxKSzVyPUCuNFg6OjFizszN Mnm5V2FPT0WU
K-562 Mk\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfpZ25SUUN3ME2wMlIzPDN{IN88US=> MmS3V2FPT0WU
ST486 Ml7yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3v4ZmlEPTB;MD62PFU1KM7:TR?= NX\GNZVSW0GQR1XS
NCI-H1436 NGDQN|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTBwOUe4NFEh|ryP M4O5VHNCVkeHUh?=
NOS-1 NYnLc5pQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HCUmlEPTB;MT62OVM5OyEQvF2= M{XaenNCVkeHUh?=
A498 MlPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTJwNUeyNlMh|ryP NHrlfldUSU6JRWK=
BE-13 M13xWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTJwNkKxNFYh|ryP NWTlc5VjW0GQR1XS
NCI-H1770 NY\6SnQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWD4SnNzUUN3ME21MlU4OjZ{IN88US=> NHeyUmFUSU6JRWK=
LB2241-RCC MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7KTWM2OD16LkC3N|g1KM7:TR?= M{G0N3NCVkeHUh?=
SCC-15 Mlu3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zoXGlEPTB;MUCuO|c5QCEQvF2= M4rHZ3NCVkeHUh?=
BB49-HNC MmLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrsTWM2OD1zND6zN|M2KM7:TR?= M3\ONHNCVkeHUh?=
LB2518-MEL NUT4bWI6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXT1cotPUUN3ME2xOk43ODl2IN88US=> MWnTRW5ITVJ?
TE-441-T M1\NNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jC[WlEPTB;MUeuNlg5PiEQvF2= NVvuR3o5W0GQR1XS
HH NGjOXGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEC2enVKSzVyPUG3MlM6QTlizszN MnvJV2FPT0WU
LC4-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXsTWM2OD1zOD6wOlUzKM7:TR?= Ml;ZV2FPT0WU
KARPAS-45 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTF6LkG4OFgh|ryP MmXtV2FPT0WU
LB1047-RCC MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH:0cFRKSzVyPUG4MlQ1PTJizszN M{O3dXNCVkeHUh?=
RS4-11 M2Pxdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTJyLkOzNFgh|ryP MYfTRW5ITVJ?
ALL-PO M{HFfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXOzT|Y4UUN3ME2yNE45OTR7IN88US=> M3LCWnNCVkeHUh?=
GDM-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXnOXVvUUN3ME2yNk42QTR3IN88US=> M4Lr[HNCVkeHUh?=
DMS-79 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXVTWM2OD1{ND60PVM1KM7:TR?= MljYV2FPT0WU
NB10 M4rXcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorrTWM2OD1{Nj60Olk6KM7:TR?= M4DvfHNCVkeHUh?=
LS-513 M1HFdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPFTWM2OD1{Nj64PFQ4KM7:TR?= NXzuUmtGW0GQR1XS
L-540 Mm\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LvV2lEPTB;Mk[uPVE1OyEQvF2= NF3mVZBUSU6JRWK=
ES1 M{D1Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTJ5LkWyNUDPxE1? NYe1R3l3W0GQR1XS
NTERA-S-cl-D1 Mnn6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTNyLkWwPVMh|ryP MXrTRW5ITVJ?
EW-1 NWfweJk2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml:wTWM2OD1|Mj65OFU1KM7:TR?= NF;Qcm1USU6JRWK=
Calu-6 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2G2fGlEPTB;M{OuNVg2PSEQvF2= NH;J[|dUSU6JRWK=
CTV-1 MofJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPjN5FlUUN3ME2zN{46Pzh7IN88US=> MV;TRW5ITVJ?
YT NEj1VXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPtNYg6UUN3ME2zPE42OjB7IN88US=> NI\2c2RUSU6JRWK=
TE-6 NUXnNWFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjoTWM2OD12MT6yO|k5KM7:TR?= NHnOOmdUSU6JRWK=
HT-144 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTvZ5FKSzVyPUSxMlU1QDZizszN NWnYdnNCW0GQR1XS
EW-13 M1u4Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUX0b3d{UUN3ME20Nk4zPzlzIN88US=> NW\QXZlqW0GQR1XS
KALS-1 NHLEZmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnr[Ww1UUN3ME20N{4yOzJ7IN88US=> NGDjXJpUSU6JRWK=
D-336MG MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jYXmlEPTB;NEWuPVU6QSEQvF2= MWfTRW5ITVJ?
TE-11 M4jaPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTR4Lk[1N{DPxE1? Mn7LV2FPT0WU
EB2 M{P1PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLTXIx2UUN3ME20Ok43QTlizszN MUHTRW5ITVJ?
SK-N-DZ MnLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnQTWM2OD12OD6wPVYyKM7:TR?= MkixV2FPT0WU
SW684 MlvSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{f0fmlEPTB;NEiuNlY6PSEQvF2= MVzTRW5ITVJ?
EW-18 NF65UY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH6ydVFKSzVyPUS4MlQ{QTVizszN NIqwTXBUSU6JRWK=
RL95-2 NGfTfFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonTTWM2OD13MD6wO|Eh|ryP MVHTRW5ITVJ?
CHP-126 M1\zcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonxTWM2OD13MD64PVA2KM7:TR?= NHXE[XZUSU6JRWK=
NCI-H1395 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDsTWM2OD13MT63PFM2KM7:TR?= M{jVPXNCVkeHUh?=
TE-15 NX60PI5[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTV{LkK1OVYh|ryP NX[zT3pKW0GQR1XS
ES4 Mlv6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPCPFE3UUN3ME21Nk46Pzd3IN88US=> NXrKbGU3W0GQR1XS
TE-1 NFL2b5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\ETWM2OD13Mz65OFU2KM7:TR?= M2TFbXNCVkeHUh?=
KY821 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoS3TWM2OD14ND6yOVUzKM7:TR?= MVHTRW5ITVJ?
LC-2-ad M17aTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTZ3Lke2NFEh|ryP NV3JbGtHW0GQR1XS
SW872 NGTD[2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEGwdotKSzVyPU[3MlQ{QDJizszN MWPTRW5ITVJ?
ES5 NHv5[mVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmqzTWM2OD14Nz62PVY5KM7:TR?= NWnPUYxqW0GQR1XS
RPMI-6666 NHHXN45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LEWmlEPTB;N{GuNFMzKM7:TR?= NXO0OoNuW0GQR1XS
COLO-829 NGH0VGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rNV2lEPTB;N{KuOlk5PyEQvF2= M3;SUXNCVkeHUh?=
KP-N-YS NH3CblRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTd{LkexN|kh|ryP Mn7TV2FPT0WU
GI-1 MkX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGryTXZKSzVyPUezMlI5PjhizszN M2S4NnNCVkeHUh?=
ETK-1 NUX0dHdZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvITWM2OD15Mz60PVMzKM7:TR?= M{SzUHNCVkeHUh?=
LXF-289 MlnSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nKWmlEPTB;N{OuO|I6KM7:TR?= NYniTlZQW0GQR1XS
CAS-1 NYHa[HlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPrdJdKSzVyPUezMlg5PTdizszN MojsV2FPT0WU
EW-22 MmjTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1e1XWlEPTB;N{SuO|EyPSEQvF2= NV\oVIlWW0GQR1XS
NCI-H2196 M3HwVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4WyeGlEPTB;N{WuOlM4QSEQvF2= MWfTRW5ITVJ?
EoL-1-cell MoS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRThzLk[5OlMh|ryP M4LKbXNCVkeHUh?=
D-247MG NGjjXGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTh{LkCyOFgh|ryP M3rReXNCVkeHUh?=
Becker NVfTc3h2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1roZmlEPTB;OEKuN|Q5OSEQvF2= NXvpV5hPW0GQR1XS
IST-MEL1 NFnEZnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\vT2lEPTB;OEKuN|Q5OiEQvF2= NV7weIdvW0GQR1XS
MDA-MB-134-VI M3rXfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1r5e2lEPTB;OEKuOVk6PiEQvF2= MlPGV2FPT0WU
NCI-H1092 MmPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\lU4lKSzVyPUi0MlAyQTdizszN M3z5VnNCVkeHUh?=
HCC2218 Mk\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHG0eoVKSzVyPUi2Mlc6OTNizszN MUfTRW5ITVJ?
GI-ME-N NFnHU3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3q5NGlEPTB;OEeuO|Y6QSEQvF2= NEewNotUSU6JRWK=
AM-38 NVLqeoQxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTh6LkO5OVMh|ryP NUHWfGpUW0GQR1XS
KNS-42 MlnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7iSnNKSzVyPUi5MlExOThizszN M1PtUXNCVkeHUh?=
C8166 MlftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjBRZJRUUN3ME24PU43OTJ3IN88US=> MU\TRW5ITVJ?
Ramos-2G6-4C10 M2G2Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvvTWM2OD16OT64O|E6KM7:TR?= NWj3R2J[W0GQR1XS
CTB-1 NFjZSXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrFTWM2OD17MD62N|U4KM7:TR?= NHX2NotUSU6JRWK=
NCI-H526 NEHyR3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLnd|FKSzVyPUmyMlQyODNizszN MVnTRW5ITVJ?
ECC4 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFezXZZKSzVyPUm0MlI2PTVizszN MW\TRW5ITVJ?
NCCIT M{HTVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnNU3k2UUN3ME25OU4{Ojl{IN88US=> NVTnXZdzW0GQR1XS
MZ7-mel MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{OzcmlEPTB;OUWuPVA1KM7:TR?= NH\Vd4xUSU6JRWK=
COLO-684 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknaTWM2OD17Nj6yN|g2KM7:TR?= MmfqV2FPT0WU
SF126 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnqXJFKSzVyPUm3MlUzOTdizszN MXTTRW5ITVJ?
NB14 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUm5cY9MUUN3ME25PE46OjB6IN88US=> M{nmb3NCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo Imatinib produces a different antitumor effect on three xenografted tumors derived from surgical samples of fresh human small cell lung cancers, with 80%, 40% and 78% growth inhibition of SCLC6, SCLC61 and SCLC108 tumors, respectively, and no significant inhibition of SCLC74 growth. [5] In high fat fed ApoE(-/-) mice, Imatinib significantly reduces the high fat-induced lipid staining area by 30%, 27% and 35% compared to high-fat diet untreated controls when dosed by gavage at 10, 20 and 40 mg/kg, respectively, and suppresses carotid artery lipid accumulation. [6]


Kinase Assay:


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PDGF receptor kinase activity:

PDGF receptor is immunoprecipitated from BALB/c 3T3 cell extracts with rabbit antiserum to the murine PDGF receptor for 2 hours on ice. Protein A-Sepharose beads are used to collect the antigen-antibody complexes. The immunoprecipitates are washed twice with TNET (50 mM Tris, pH 7.5, 140 mM NaCl, 5 mM EDTA, 1% Triton X-100), once with TNE (50 mM Tris, pH 7.5, 140 mM EDTA), and once with kinase buffer (20 mM Tris, pH 7.5,10 mM MgCl2). After stimulation with PDGF (50 ng/mL) for 10 minutes at 4 °C, different concentrations of drug are added to the reaction mixture. PDGF receptor kinase activity is determined by incubation with 10 μCi [7-33P]-ATP and l μM ATP for 10 minutes at 4 °C. Immune complexes are separated by SDS-PAGE on 7.5% gels.
Cell Research:


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  • Cell lines: BON-1 cells and NCI-H727 cells
  • Concentrations: ~100 μM
  • Incubation Time: 48 hours
  • Method:

    BON-1 cells and NCI-H727 cells are seeded into flat-bottomed 96-well plates in triplicate and allowed to adhere overnight in 10% fetal bovine serum-supplemented DMEM or RPMI 1640 complete medium, respectively; the medium is then exchanged for serum-free medium (negative control) or serum-free medium containing serial dilutions of Imatinib. After 48 hours (control cultures do not reach confluence), the number of metabolically active cells is determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and absorbance is measured in a Packard Spectra microplate reader at 540 nm. Growth inhibition is calculated using the following formula: inhibition rate = (1 − a / b) × 100%, where a and b are the absorbance values of the treated and control groups, respectively.

    (Only for Reference)
Animal Research:


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  • Animal Models: SCLC6, SCLC61, SCLC 74 and SCLC108 small cell lung cancers are injected into Swiss mice (nu/nu, female).
  • Formulation: Imatinib is diluted in water.
  • Dosages: 70 or 100 mg/kg
  • Administration: Administered via i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 33 mg/mL (66.85 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order:
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 493.6


CAS No. 152459-95-5
Storage powder
in solvent
Synonyms CGP057148B, ST-1571

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00044304 Recruiting Hypereosinophilic Syndrome National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) August 22, 2002 Phase 2
NCT02644525 Not yet recruiting Loaisis National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) December 21, 2015 Phase 2
NCT03007147 Not yet recruiting B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1|BCR-ABL1 Fusion Protein Expression|Minimal Residual Disease|Philadelphia Chromosome Positive|T Acute Lymphoblastic Leukemia|Untreated Adult Acute Lymphoblastic Leukemia|Untreated Childhood Acute Lymphoblastic Leukemia Childrens Oncology Group|National Cancer Institute (NCI) July 2017 Phase 3
NCT03023046 Not yet recruiting Adult Acute Lymphoblastic Leukemia|Adult Lymphoblastic Lymphoma|CD20 Positive|Philadelphia Chromosome Positive University of Washington|National Cancer Institute (NCI) February 2017 Phase 2
NCT02538926 Not yet recruiting B Acute Lymphoblastic Leukemia|B Lymphoblastic Lymphoma|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent B Lymphoblastic Lymphoma|Recurrent T Lymphoblastic Leukemia/Lymphoma|Refractory B Lymphoblastic Lymphoma|Refractory T Lymphoblastic Lymphoma|T Acute Lymphoblastic Leukemia|T Lymphoblastic Lymphoma University of Washington|National Cancer Institute (NCI) January 2017 Phase 2
NCT02924714 Recruiting Gastrointestinal Stromal Tumor Oslo University Hospital January 2017 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

  • Question 1:

    Could you please advise whether it is a clear solution for compound dissolved in vehicle 2% DMSO+30% PEG 300+2% Tween 80+ddH2O?

  • Answer:

    For S2475 Imatinib (STI571), it is soluble in 2% DMSO+30% PEG 300+2% Tween 80+ddH2O at 2mg/ml. When making the solution, please dissolve the compound in DMSO clearly first. If it dissolves not readily, please sonicate and warm it in water bath at 45-50C. Then add PEG and Tween. After they mixed well, dilute with water.

  • Question 2:

    What is the difference between S2475 (Imatinib) and S1026 (Imatinib Mesylate)? Are they water soluble?

  • Answer:

    S2475 is free base of Imatinib while S1026 is a solt form of Imatinib. They have exactly the same biological activity but different solubility. S1026 can be dissolved in water, but S2475 is not soluble in water. S2475 can be dissolved in DMSO at up to 3mg/ml.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID