Imatinib (Gleevec)

Related PDGFR Inhibitors

• Linifanib (ABT-869)

  Linifanib (ABT-869) is a novel, potent ATP-competitive RTK inhibitor for KDR, CSF-1R, Flt-1, Flt-3 and PDGFRβ with IC50 of 4 nM, 3 nM, 3 nM, 3 nM, and 66 nM respectively.

• BIBF1120 (Vargatef)

  BIBF1120 (Vargatef) is a potent inhibitor of VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.

• Dovitinib (TKI-258)

  Dovitinib (TKI258, CHIR258) is a novel multi-target inhibitor for Flt3, c-Kit, FGFR1/3, VEGFR1/2/3, PDGFRα/β with IC50 of 1 nM, 2 nM, 8 nM/9 nM and 10 nM/13 nM/8 nM, 210 nM/27 nM respectively.

• Motesanib Diphosphate (AMG-706)

  Motesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3, PDGFR, c-Kit and Ret with IC50 of 2 nM/3 nM/6 nM, 84 nM, 8 nM and 59 nM, respectively.

• Masitinib (AB1010)

  Masitinib is a novel tyrosine kinases inhibitor for Kit and PDGFRα/β with IC50 of 200 nM and 540 nM/800 nM, resectively.

• Tivozanib (AV-951)

  AV-951 (Tivozanib, KRN-951) is a potent and selective VEGFR inhibitor for VEGFR1/2/3 with IC50 of 0.21 nM/0.16 nM/0.24 nM and also inhibits PDGFR and c-Kit with IC50 of 1.72 nM and 1.63 nM, respectively.

• Amuvatinib (MP-470)

  MP-470 (Amuvatinib) is a potent and multi-targeted inhibitor of c-Kit^D816H, PDGFα^V561D and Flt3^D835Y with IC50 of 10 nM, 40 nM and 81 nM, respectively.

• Ki8751

  Ki8751 is a potent and selective inhibitor of VEGFR2, PDGFRα and c-Kit with IC50 of 0.9 nM, 67 nM and 40 nM, respectively.

• TSU-68 (SU6668)

  TSU-68 (SU6668, Orantinib) is a potent inhibitor of Flk-1/KDR, FGFR1 and PDGFRβ with K_i of 2.1 μM, 1.2 μM, and 8 nM, respectively.

• CP 673451

  CP 673451 is a potent PDGFR-β inhibitor with an IC50 of 1 nM.