Imatinib (STI571)

Catalog No.S2475 Synonyms: CGP057148B, ST-1571

Imatinib (STI571) Chemical Structure

Molecular Weight(MW): 493.6

Imatinib (STI571) is a multi-target inhibitor of tyrosine kinase with inhibition for v-Abl, c-Kit and PDGFR, IC50 values are 0.6 μM, 0.1 μM and 0.1 μM in cell-free or cell-based assays, respectively.

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Cited by 35 Publications

6 Customer Reviews

  • Ba/F3-p210T315I cells were treated with indicated concentrations of imatinib with or without PDMP for 24 h. Apoptosis was determined as in A. Data are shown as percentage of sub-G1 for apoptosis in triplicate cultures. *P<0.05.

    FASEB J 2011 25, 3661-3673. Imatinib (STI571) purchased from Selleck.

    Targeting KITLG through c-KIT inhibition using Imatinib; one representative experiment is shown (n = 4).

    Oncotarget, 2016, 7(34):54583-54595. Imatinib (STI571) purchased from Selleck.


    Inhibition of thymidine (a and b) and cytarabine (c and d) uptake with imatinib. K562 cells (a and c) and MEG-01 cells (b and d) were incubated at 37 ◦C for 15 min with imatinib transport buffer, and then incubated with 0.5 Ci of [3H] thymidine or [3H] cytarabine for an additional 5 min in presence of imatinib. Cells were then washed 3 times, lysed and radioactivity associated to cell pellets was quantified. DMSO, dimethylsulfoxide; DPD, dipyridamole.

    Leukemia Res 2012 36, 1311-1314. Imatinib (STI571) purchased from Selleck.

    ZFX regulates imatinib sensitivity and PI3K/Akt signaling pathway in CML cells. Viability of cells transfected with si-ZFX at the indicated doses of imatinib for 24 h (a). Colonies of leukemia cells and imatinib-resistant cells transfected with si-ZFX following treatment with imatinib for 10 days (b). Western blot analysis of Akt, p-Akt, CyclinD1, CyclinE1, Bcl-2, and Caspase-3 in K562 and K562/G01 cells transfected with si-ZFX for 2 days (c). The relative densities of proteins were quantified and normalized to b-Actin (d). Values represented the mean ± SD data from experiments in triplicate. *P\0.05 and **P\0.01

    Cell Biochem Biophys, 2016, 74(2):277-83. Imatinib (STI571) purchased from Selleck.

  • Cell Viability assay results. A2C12, BetaD5, GammaA3, GammaD12, A549, CaCo2, HepG2 cell lines were treated with imatinib mesylate for 24h and 96h.

    Dr. Thomas Kruwel of Fraunhofer. Imatinib (STI571) purchased from Selleck.

    A. Viability curve for the c-Kit mutant MelMS melanoma cell line treated with increasing concentrations of imatinib for 72h (relative to DMSO-treated controls; mean ±sd; n=3) B. MelMS melanoma cells were treated with 50nM imatinib for 24h. The effects on c-Kit, ERK and AKT activation were determined by immunoblotting.

    Dr. Helen Rizos from the university of Sydney. Imatinib (STI571) purchased from Selleck.

Purity & Quality Control

Choose Selective PDGFR Inhibitors

Biological Activity

Description Imatinib (STI571) is a multi-target inhibitor of tyrosine kinase with inhibition for v-Abl, c-Kit and PDGFR, IC50 values are 0.6 μM, 0.1 μM and 0.1 μM in cell-free or cell-based assays, respectively.
(Cell-free assay)
c-Kit [2]
(M-07e cells)
v-Abl [1]
(Cell-free assay)
100 nM 100 nM 600 nM
In vitro

In vitro assays for inhibition of a panel of tyrosine and serine/threonine protein kinases show that Imatinib inhibits the v-Abl tyrosine kinase and PDGFR potently with an IC50 of 0.6 and 0.1 μM, respectively. [1] Imatinib inhibits the SLF-dependent activation of wild-type c-kit kinase activity with a IC50 for these effects of approximately 0.1 μM, which is similar to the concentration required for inhibition of PDGFR. [2] Imatinib exhibits growth-inhibitory activity on the human bronchial carcinoid cell line NCI-H727 and the human pancreatic carcinoid cell line BON-1 with an IC50 of 32.4 and 32.8 μM, respectively. [3] A recent study shows that Imatinib has the potential to exert its antileukemia effects in chronic myelogenous leukemia by down-regulating hERG1 K(+) channels, which are highly expressed in leukemia cells and appear of exceptional importance in favoring leukemogenesis. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EM-2 NXTiWW5uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrqVoZKSzVyPUCuNFg5QCEQvF2= M1fL[nNCVkeHUh?=
BV-173 M3K5PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{K3T2lEPTB;MD6xPFc1KM7:TR?= NFraeYdUSU6JRWK=
K-562 NILvcWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jk[GlEPTB;MD6yNlQ{OiEQvF2= MorWV2FPT0WU
CGTH-W-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTrZ5VKSzVyPUCuN|g{PzRizszN M{fvc3NCVkeHUh?=
ST486 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTBwNki1OEDPxE1? MWLTRW5ITVJ?
NCI-H1436 NEewenVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;pOGlEPTB;MD65O|gxOSEQvF2= NWfhZVh[W0GQR1XS
NOS-1 M3r4Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGK2R41KSzVyPUGuOlU{QDNizszN MVLTRW5ITVJ?
A498 MoPoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PWcGlEPTB;Mj61O|IzOyEQvF2= NGn5RXZUSU6JRWK=
NCI-H1770 MonJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTVwNUeyOlIh|ryP NIfFNoNUSU6JRWK=
IMR-5 M3faWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDaVZNrUUN3ME22MlIzOTR5IN88US=> MVrTRW5ITVJ?
LB2241-RCC MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRThwMEezPFQh|ryP NH3MfmZUSU6JRWK=
TGBC24TKB NHvvOmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHnTWM2OD16LkO0NFUzKM7:TR?= M3HjUHNCVkeHUh?=
SCC-15 M3L0Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPUTpBKSzVyPUGwMlc4QDhizszN NHzPeY1USU6JRWK=
BB49-HNC MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTF2LkOzN|Uh|ryP Mn\JV2FPT0WU
ES7 MknoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkK2TWM2OD1zND63N|c6KM7:TR?= Mn22V2FPT0WU
LB2518-MEL MnPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTF4Lk[wPVQh|ryP M1jsRnNCVkeHUh?=
NCI-H510A MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGW5WlBKSzVyPUG3MlI1PDJizszN M13hdnNCVkeHUh?=
HH MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fuN2lEPTB;MUeuN|k6QSEQvF2= NILZblZUSU6JRWK=
LC4-1 MnHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTnTWM2OD1zOD6wOlUzKM7:TR?= NGXxT2hUSU6JRWK=
KARPAS-45 NFmwVopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\N[mlEPTB;MUiuNVg1QCEQvF2= Ml\2V2FPT0WU
LB1047-RCC MoewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDaTWM2OD1zOD60OFUzKM7:TR?= NFPZZldUSU6JRWK=
NKM-1 MonBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DtT2lEPTB;MUmuN|U2OiEQvF2= NHr0THZUSU6JRWK=
SCLC-21H MmrKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fkXWlEPTB;MkCuNVI1PiEQvF2= NF7mS2hUSU6JRWK=
RS4-11 NED0SpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1mxXmlEPTB;MkCuN|MxQCEQvF2= Ml;0V2FPT0WU
GDM-1 NGe4fXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTJ{LkW5OFUh|ryP MlHMV2FPT0WU
MPP-89 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFX6fVJKSzVyPUK1MlY5PzRizszN NEjiZndUSU6JRWK=
NB10 NVjpfHpXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTJ4LkS2PVkh|ryP NE[3d2tUSU6JRWK=
L-540 NVXncotHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7UTWM2OD1{Nj65NVQ{KM7:TR?= MYTTRW5ITVJ?
NTERA-S-cl-D1 M2jReWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrxSmJKSzVyPUOwMlUxQTNizszN M{PsdXNCVkeHUh?=
EW-1 NFTHVWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;scFc3UUN3ME2zNk46PDV2IN88US=> NXvQdZR1W0GQR1XS
Calu-6 NGnaS2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nOe2lEPTB;M{OuNVg2PSEQvF2= NVrTWoFmW0GQR1XS
CTV-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDDTWM2OD1|Mz65O|g6KM7:TR?= M3jkOHNCVkeHUh?=
YT MlzwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\iZ2lEPTB;M{iuOVIxQSEQvF2= M2\uNnNCVkeHUh?=
TE-6 MkPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHOTWM2OD12MT6yO|k5KM7:TR?= Mnu5V2FPT0WU
EW-13 M{LObmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVu4cIFLUUN3ME20Nk4zPzlzIN88US=> M{\5SXNCVkeHUh?=
MOLT-16 M2XXOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTUTWM2OD12NT6wO|UzKM7:TR?= Mmq1V2FPT0WU
TE-11 NHLFSXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DjUmlEPTB;NE[uOlU{KM7:TR?= NVTyTm4yW0GQR1XS
EB2 NX34SG9oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXm2T3ppUUN3ME20Ok43QTlizszN NYPvOXVVW0GQR1XS
SW684 NUjmcWd1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37TUmlEPTB;NEiuNlY6PSEQvF2= MWXTRW5ITVJ?
EW-18 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1yyR2lEPTB;NEiuOFM6PSEQvF2= NVvL[FR5W0GQR1XS
RL95-2 M3vkOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTVyLkC3NUDPxE1? NYDUS3I3W0GQR1XS
CHP-126 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTmOWtKSzVyPUWwMlg6ODVizszN MljpV2FPT0WU
TE-15 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzLTWM2OD13Mj6yOVU3KM7:TR?= MXLTRW5ITVJ?
ES4 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTV{Lkm3O|Uh|ryP MWHTRW5ITVJ?
TE-1 NHPCXYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzDNVhLUUN3ME21N{46PDV3IN88US=> M1vuWnNCVkeHUh?=
SIMA NIOzXY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnibnhxUUN3ME21O{4{OzFzIN88US=> M2ToW3NCVkeHUh?=
LB647-SCLC MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17YVWlEPTB;NkSuNVE5QCEQvF2= M17vSnNCVkeHUh?=
KY821 NFHkc4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fEN2lEPTB;NkSuNlU2OiEQvF2= MlS2V2FPT0WU
LC-2-ad M3m3PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnviTWM2OD14NT63OlAyKM7:TR?= Mly4V2FPT0WU
KP-N-RT-BM-1 NF3xcJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XRV2lEPTB;Nk[uOlM3PiEQvF2= M{S3enNCVkeHUh?=
SW872 NVfTW21yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2myV2lEPTB;NkeuOFM5OiEQvF2= MUnTRW5ITVJ?
ES5 NHvOV|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPITWM2OD14Nz62PVY5KM7:TR?= NGnXV5RUSU6JRWK=
SK-NEP-1 NXi0[4R4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3Pye2lEPTB;NkiuN|gxOyEQvF2= NHzTUm5USU6JRWK=
RPMI-6666 MkHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvofpM2UUN3ME23NU4xOzJizszN M2rlTnNCVkeHUh?=
COLO-829 M4rpXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELvR2lKSzVyPUeyMlY6QDdizszN MV;TRW5ITVJ?
KP-N-YS MlLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3hTWM2OD15Mj63NVM6KM7:TR?= NGLTdZhUSU6JRWK=
GI-1 NUn0Z|k4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTd|LkK4Olgh|ryP MnroV2FPT0WU
ETK-1 M2XFNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDHfWNKSzVyPUezMlQ6OzJizszN MkW1V2FPT0WU
LXF-289 M3;QfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrpVW9uUUN3ME23N{44OjlizszN Mk\YV2FPT0WU
CAS-1 MlyyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13zcGlEPTB;N{OuPFg2PyEQvF2= NESw[2tUSU6JRWK=
EW-22 M{jaSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETENIhKSzVyPUe0MlcyOTVizszN MV3TRW5ITVJ?
NCI-H2196 Mn;SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonmTWM2OD15NT62N|c6KM7:TR?= MXzTRW5ITVJ?
EoL-1-cell MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTscXJKSzVyPUixMlY6PjNizszN NYnRbJBuW0GQR1XS
D-247MG M{DnTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjxTWM2OD16Mj6wNlQ5KM7:TR?= MnnIV2FPT0WU
Becker M3\Z[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTh{LkO0PFEh|ryP NH7ISHJUSU6JRWK=
IST-MEL1 M{DRO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTh{LkO0PFIh|ryP NIjtcYJUSU6JRWK=
MDA-MB-134-VI M4SyZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1iyZmlEPTB;OEKuOVk6PiEQvF2= MlfjV2FPT0WU
NCI-H1092 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHy3ZplKSzVyPUi0MlAyQTdizszN MUHTRW5ITVJ?
HCC2218 NUThO3NiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF34Zo1KSzVyPUi2Mlc6OTNizszN MWfTRW5ITVJ?
GI-ME-N NGP1e|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzrTWM2OD16Nz63Olk6KM7:TR?= NWTDNWFKW0GQR1XS
C8166 NXXi[2prT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHmwb3NKSzVyPUi5MlYyOjVizszN NULCTGZqW0GQR1XS
Ramos-2G6-4C10 MmjJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmOwTWM2OD16OT64O|E6KM7:TR?= NHfXfXZUSU6JRWK=
CTB-1 M3zPdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjjTWM2OD17MD62N|U4KM7:TR?= M{\mRnNCVkeHUh?=
NCCIT M1:5R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\SWIdKSzVyPUm1MlMzQTJizszN Mle0V2FPT0WU
COLO-684 NXjPSIxjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPQVmtKSzVyPUm2MlI{QDVizszN M1\JUnNCVkeHUh?=
SU-DHL-1 NH\uO5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{H3V2lEPTB;OU[uPVg1OiEQvF2= MXjTRW5ITVJ?
SF126 NWPuWoxsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fjdWlEPTB;OUeuOVIyPyEQvF2= MW\TRW5ITVJ?
NMC-G1 NVX2[I9jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILoS5FKSzVyPUm4MlQ2PTRizszN M1Kz[HNCVkeHUh?=
NB14 MmXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTl6LkmyNFgh|ryP MW\TRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo Imatinib produces a different antitumor effect on three xenografted tumors derived from surgical samples of fresh human small cell lung cancers, with 80%, 40% and 78% growth inhibition of SCLC6, SCLC61 and SCLC108 tumors, respectively, and no significant inhibition of SCLC74 growth. [5] In high fat fed ApoE(-/-) mice, Imatinib significantly reduces the high fat-induced lipid staining area by 30%, 27% and 35% compared to high-fat diet untreated controls when dosed by gavage at 10, 20 and 40 mg/kg, respectively, and suppresses carotid artery lipid accumulation. [6]


Kinase Assay:


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PDGF receptor kinase activity:

PDGF receptor is immunoprecipitated from BALB/c 3T3 cell extracts with rabbit antiserum to the murine PDGF receptor for 2 hours on ice. Protein A-Sepharose beads are used to collect the antigen-antibody complexes. The immunoprecipitates are washed twice with TNET (50 mM Tris, pH 7.5, 140 mM NaCl, 5 mM EDTA, 1% Triton X-100), once with TNE (50 mM Tris, pH 7.5, 140 mM EDTA), and once with kinase buffer (20 mM Tris, pH 7.5,10 mM MgCl2). After stimulation with PDGF (50 ng/mL) for 10 minutes at 4 °C, different concentrations of drug are added to the reaction mixture. PDGF receptor kinase activity is determined by incubation with 10 μCi [7-33P]-ATP and l μM ATP for 10 minutes at 4 °C. Immune complexes are separated by SDS-PAGE on 7.5% gels.
Cell Research:


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  • Cell lines: BON-1 cells and NCI-H727 cells
  • Concentrations: ~100 μM
  • Incubation Time: 48 hours
  • Method:

    BON-1 cells and NCI-H727 cells are seeded into flat-bottomed 96-well plates in triplicate and allowed to adhere overnight in 10% fetal bovine serum-supplemented DMEM or RPMI 1640 complete medium, respectively; the medium is then exchanged for serum-free medium (negative control) or serum-free medium containing serial dilutions of Imatinib. After 48 hours (control cultures do not reach confluence), the number of metabolically active cells is determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and absorbance is measured in a Packard Spectra microplate reader at 540 nm. Growth inhibition is calculated using the following formula: inhibition rate = (1 − a / b) × 100%, where a and b are the absorbance values of the treated and control groups, respectively.

    (Only for Reference)
Animal Research:


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  • Animal Models: SCLC6, SCLC61, SCLC 74 and SCLC108 small cell lung cancers are injected into Swiss mice (nu/nu, female).
  • Formulation: Imatinib is diluted in water.
  • Dosages: 70 or 100 mg/kg
  • Administration: Administered via i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 4 mg/mL (8.1 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents individually and in order:
2% DMSO+30% PEG 300+2% Tween 80+ddH2O

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 493.6


CAS No. 152459-95-5
Storage powder
Synonyms CGP057148B, ST-1571

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00044304 Recruiting Hypereosinophilic Syndrome National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) August 22, 2002 Phase 2
NCT02644525 Not yet recruiting Loaisis National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) December 21, 2015 Phase 2
NCT03007147 Not yet recruiting B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1|BCR-ABL1 Fusion Protein Expression|Minimal Residual Disease|Philadelphia Chromosome Positive|T Acute Lymphoblastic Leukemia|Untreated Adult Acute Lymphoblastic Leukemia|Untreated Childhood Acute Lymphoblastic Leukemia Childrens Oncology Group|National Cancer Institute (NCI) July 2017 Phase 3
NCT03023046 Not yet recruiting Adult Acute Lymphoblastic Leukemia|Adult Lymphoblastic Lymphoma|CD20 Positive|Philadelphia Chromosome Positive University of Washington|National Cancer Institute (NCI) February 2017 Phase 2
NCT02538926 Not yet recruiting B Acute Lymphoblastic Leukemia|B Lymphoblastic Lymphoma|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent B Lymphoblastic Lymphoma|Recurrent T Lymphoblastic Leukemia/Lymphoma|Refractory B Lymphoblastic Lymphoma|Refractory T Lymphoblastic Lymphoma|T Acute Lymphoblastic Leukemia|T Lymphoblastic Lymphoma University of Washington|National Cancer Institute (NCI) January 2017 Phase 2
NCT02924714 Recruiting Gastrointestinal Stromal Tumor Oslo University Hospital January 2017 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    What is the difference between S2475 (Imatinib) and S1026 (Imatinib Mesylate)? Are they water soluble?

  • Answer:

    S2475 is free base of Imatinib while S1026 is a solt form of Imatinib. They have exactly the same biological activity but different solubility. S1026 can be dissolved in water, but S2475 is not soluble in water. S2475 can be dissolved in DMSO at up to 3mg/ml.

PDGFR Signaling Pathway Map

PDGFR Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID