Research Area
Product Type
United States ( Change Country )
INO-1001 Chemical Structure
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Biological Activity
INO-1001 is an isoindolinone derivative and potent inhibitor of the nuclear enzyme PARP (poly (ADP-ribose) polymerase) with chemosensitization and radiosensitization properties[1,2]. INO-1001 inhibits PARP, which may result in inhibition of tumor cell DNA repair mechanisms and, so, tumor cell resistance to chemotherapy and radiation therapy. PARP enzymes are activated by DNA breaks and have been implicated in the repair of DNA single-strand breaks (SSB). In addition,INO-1001 improves the recovery of myocardial and endothelial function after hypothermic cardiac arrest and reduces pulmonary injury associated with extracorporal circulation. [3,4,5]
References on INO-1001
- [1] Cancer Letters 2004;205:155–160
- [2] Invest New Drugs 2008;26:1–5
- [3] Brain Research 2005;1041:149– 156
- [4] Life Sciences 2006;79:317–323
Chemical Information
| Molecular Weight (WM): | 136.15 |
|---|---|
| Formula: | C7H8N2O |
| CAS No.: | 3544-24-9 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥27mg/mL |
| Water ≥27mg/mL | |
| Ethanol ≥27mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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