Catalog No.S2240 Synonyms: SPM 907
Molecular Weight(MW): 527.65
Fesoterodine Fumarate is a prodrug of 5-hydroxymethyl tolterodine that is a muscarinic AChR receptor antagonist, used to treat overactive bladder syndrome.
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|Description||Fesoterodine Fumarate is a prodrug of 5-hydroxymethyl tolterodine that is a muscarinic AChR receptor antagonist, used to treat overactive bladder syndrome.|
Fesoterodine is rapidly and extensively converted to 5-HMT, such that the pharmacologic activity appears to be primarily attributable to 5-HMT.  Fesoterodine is a competitive antagonist of cholinergic agonist-stimulated responses in human M1-M5 cell lines and has a similar potency and selectivity profile to the radioligand-binding studies. Fesoterodine causes a rightward shift of the concentration-response curve for carbachol with no depression of the maximum in rat bladder strips, and concentration-dependently reduces contractions induced by electrical field stimulation (EFS).  Fesoterodine is hydrolyzed by nonspecific esterases to 5-hydroxmethyl tolterodine (5-HMT), which is the active metabolite and is responsible for all its antimuscarinic activity. 
|In vitro||DMSO||100 mg/mL (189.51 mM)|
|Water||100 mg/mL (189.51 mM)|
|Ethanol||100 mg/mL (189.51 mM)|
* 1 mg/ml means slightly soluble or insoluble.
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02240459||Recruiting||Overactive Bladder|Mild Cognitive Impairment||University of Alberta|Pfizer||August 2016||Phase 2|
|NCT02676154||Recruiting||Autonomic Dysreflexia||University of British Columbia|Pfizer|International Collaboration On Repair Discoveries (ICORD)|Vancouver Coastal Health||February 2016||Phase 2|
|NCT02614482||Recruiting||Overactive Bladder||Stéphane Bolduc|Pfizer|Centre Hospitalier Universitaire de Québec, CHU de Québec||October 2015||Phase 3|
|NCT02262936||Terminated||Nocturia||Mount Sinai Hospital, Canada|Baycrest|The Physicians Services Incorporated Foundation||July 2015||Phase 2|Phase 3|
|NCT02501928||Recruiting||Urinary Bladder, Neurogenic||Pfizer||June 2015||Phase 3|
|NCT02385500||Not yet recruiting||Urinary Bladder, Overactive|Parkinson Disease||Sir Mortimer B. Davis - Jewish General Hospital||March 2015||Phase 4|
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