Catalog No.S2240 Synonyms: SPM 907
Molecular Weight(MW): 527.65
Fesoterodine Fumarate is a prodrug of 5-hydroxymethyl tolterodine that is a muscarinic AChR receptor antagonist, used to treat overactive bladder syndrome.
Purity & Quality Control
Choose Selective AChR Inhibitors
|Description||Fesoterodine Fumarate is a prodrug of 5-hydroxymethyl tolterodine that is a muscarinic AChR receptor antagonist, used to treat overactive bladder syndrome.|
Fesoterodine is rapidly and extensively converted to 5-HMT, such that the pharmacologic activity appears to be primarily attributable to 5-HMT.  Fesoterodine is a competitive antagonist of cholinergic agonist-stimulated responses in human M1-M5 cell lines and has a similar potency and selectivity profile to the radioligand-binding studies. Fesoterodine causes a rightward shift of the concentration-response curve for carbachol with no depression of the maximum in rat bladder strips, and concentration-dependently reduces contractions induced by electrical field stimulation (EFS).  Fesoterodine is hydrolyzed by nonspecific esterases to 5-hydroxmethyl tolterodine (5-HMT), which is the active metabolite and is responsible for all its antimuscarinic activity. 
|In vitro||DMSO||100 mg/mL (189.51 mM)|
|Water||100 mg/mL (189.51 mM)|
|Ethanol||100 mg/mL (189.51 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02240459||Recruiting||Overactive Bladder|Mild Cognitive Impairment||University of Alberta|Pfizer||August 2016||Phase 2|
|NCT02676154||Recruiting||Autonomic Dysreflexia||University of British Columbia|Pfizer|International Collaboration On Repair Discoveries (ICORD)|Vancouver Coastal Health||February 2016||Phase 2|
|NCT02614482||Recruiting||Overactive Bladder||Stéphane Bolduc|Pfizer|Centre Hospitalier Universitaire de Québec, CHU de Québec||October 2015||Phase 3|
|NCT02262936||Terminated||Nocturia||Mount Sinai Hospital, Canada|Baycrest|The Physicians Services Incorporated Foundation||July 2015||Phase 2|Phase 3|
|NCT02501928||Recruiting||Urinary Bladder, Neurogenic||Pfizer||June 2015||Phase 3|
|NCT02385500||Not yet recruiting||Urinary Bladder, Overactive|Parkinson Disease||Sir Mortimer B. Davis - Jewish General Hospital||March 2015||Phase 4|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.