Research Area
Product Type
United States ( Change Country )
Exemestane Chemical Structure
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Biological Activity
Exemestane is an irreversible, oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive breast cancer in postmenopausal women. [1]Its structure was related to the natural substrate androstenedione and it acts as a false substrate for the aromatase enzyme, an effect also known as "suicide inhibition."[1]The estrogen suppression rate for exemestane varies from 85% for estradiol (E2) to 95% for estrone (E1). [1]Exemestane was found to inhibit human placental aromatase with IC50 of 42 nM. [2]
References on Exemestane
- [] Biochimica et Biophysica Acta 2002;1587:326– 337
Chemical Information
| Molecular Weight (WM): | 296.4 |
|---|---|
| Formula: | C20H24O2 |
| CAS No.: | 107868-30-4 |
| Synonyms: |
Aromasin
|
| Dissolve in (25°C): | DMSO ≥59mg/mL |
| Water <1mg/mL | |
| Ethanol ≥15mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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