Research Area
Product Type
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Dutasteride Chemical Structure
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Biological Activity
Dutasteride is a 5-alpha-reductase inhibitor that inhibits the conversion of testosterone into dihydrotestosterone (DHT). It is used for the treatment of benign prostatic hyperplasia (BPH) and is prescibed off-label for the treatment of male pattern baldness (MPB). [1]Dutasteride inhibits both isoforms of 5-alpha reductase (5aR1 and 5aR2) to a similar extent (IC50 6nmol/l and 7 nmol/l, respectively), while finasteride only inhibits Type II. [2]Dutasteride competed for binding the LNCaP cell AR with an IC(50) approximately 1.5 µM. [3]
References on Dutasteride
- [] TheProstate 2004;58:130^144
Chemical Information
| Molecular Weight (WM): | 528.53 |
|---|---|
| Formula: | C27H30F6N2O2 |
| CAS No.: | 164656-23-9 |
| Synonyms: |
Avodart
|
| Dissolve in (25°C): | DMSO ≥106mg/mL |
| Water <1mg/mL | |
| Ethanol ≥25mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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