Catalog No.S1998 Synonyms: RO-1-9213
Molecular Weight(MW): 102.09
D-cycloserine is an analog of the amino acid D-alanine, used as an antibiotic in the treatment of tuberculosis.
Purity & Quality Control
Choose Selective Antifection Inhibitors
|Description||D-cycloserine is an analog of the amino acid D-alanine, used as an antibiotic in the treatment of tuberculosis.|
|In vivo||D-cycloserine (DCS) facilitates extinction of conditioned freezing to the light CS when no drug pre-exposure has occurred, but pre-exposure to DCS just prior to conditioning disrupted the facilitation of extinction effect in mice.  D-cycloserine (DCS) which has a high affinity for the glycine modulatory site in the NMDA receptor complex modulated memory processing in a dose-dependent manner. DCS also facilitates retention in 'senescence-accelerated mice' in which impairment of learning andmemory increases with age.  D-cycloserine (DCS) exhibits facilitated extinction of fear but are able to reacquire fear of that conditioned stimulus (CS) in a similar manner as saline-treated control rats. DCS-treated rats exhibits generalized extinction (i.e., they are less fearful of a non-extinguished CS) in comparison to controls.  D-cycloserine (DCS), an antimycobacterial agent known to cross the blood-brain barrier, binds with high affinity to this glycine modulatory site, functions as a positive modulator, and facilitates performance of learningtasks in rats. DCS appears to be a potent cognitive enhancer at doses lower than those required for antibacterial activity.  D-cycloserine injections (3.25, 15, or 30 mg/kg) before 30 non-reinforced light exposures dose-dependently enhances extinction but does not influence fear-potentiated startle in rats that does not receive extinction training. |
-  Parnas AS, et al. Neurobiol Learn Mem,?005, 83(3), 224-231.
-  Flood JF, et al. Eur J Pharmacol,?992, 221(2-3), 249-254.
-  Ledgerwood L, et al. Biol Psychiatry,?005, 57(8), 841-847.
|In vitro||Water||20 mg/mL (195.9 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02772211||Not yet recruiting||Treatment Resistant Depression||Sheba Medical Center|Teva Pharmaceuticals USA|Tel Aviv University||June 2016||Phase 4|
|NCT02687165||Recruiting||Post Treatment Lyme Syndrome (PTLS)|Chronic Pain||New York State Psychiatric Institute||January 2016||--|
|NCT02656342||Recruiting||Obsessive-Compulsive Disorder||Haukeland University Hospital|The Research Council of Norway|Helse Vest||November 2015||Phase 4|
|NCT02983734||Recruiting||Gulf War Illness||Boston University||October 2015||Phase 2|
|NCT02582515||Recruiting||Tourette Disorder|Chronic Tic Disorder||University of California, Los Angeles||October 2015||--|
|NCT02635893||Recruiting||Spinal Cord Injury||University of Miami|The Craig H. Neilsen Foundation||October 2015||Phase 4|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.