D-Cycloserine

Catalog No.S1998 Synonyms: RO-1-9213

D-Cycloserine Chemical Structure

Molecular Weight(MW): 102.09

D-cycloserine is an analog of the amino acid D-alanine, used as an antibiotic in the treatment of tuberculosis.

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Biological Activity

Description D-cycloserine is an analog of the amino acid D-alanine, used as an antibiotic in the treatment of tuberculosis.
In vivo D-cycloserine (DCS) facilitates extinction of conditioned freezing to the light CS when no drug pre-exposure has occurred, but pre-exposure to DCS just prior to conditioning disrupted the facilitation of extinction effect in mice. [1] D-cycloserine (DCS) which has a high affinity for the glycine modulatory site in the NMDA receptor complex modulated memory processing in a dose-dependent manner. DCS also facilitates retention in 'senescence-accelerated mice' in which impairment of learning andmemory increases with age. [2] D-cycloserine (DCS) exhibits facilitated extinction of fear but are able to reacquire fear of that conditioned stimulus (CS) in a similar manner as saline-treated control rats. DCS-treated rats exhibits generalized extinction (i.e., they are less fearful of a non-extinguished CS) in comparison to controls. [3] D-cycloserine (DCS), an antimycobacterial agent known to cross the blood-brain barrier, binds with high affinity to this glycine modulatory site, functions as a positive modulator, and facilitates performance of learningtasks in rats. DCS appears to be a potent cognitive enhancer at doses lower than those required for antibacterial activity. [4] D-cycloserine injections (3.25, 15, or 30 mg/kg) before 30 non-reinforced light exposures dose-dependently enhances extinction but does not influence fear-potentiated startle in rats that does not receive extinction training. [5]

Protocol

Solubility (25°C)

In vitro Water 20 mg/mL (195.9 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 102.09
Formula

C3H6N2O2

CAS No. 68-41-7
Storage powder
Synonyms RO-1-9213

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02772211 Not yet recruiting Treatment Resistant Depression Sheba Medical Center|Teva Pharmaceuticals USA|Tel Aviv University June 2016 Phase 4
NCT02687165 Recruiting Post Treatment Lyme Syndrome (PTLS)|Chronic Pain New York State Psychiatric Institute January 2016 --
NCT02656342 Recruiting Obsessive-Compulsive Disorder Haukeland University Hospital|The Research Council of Norway|Helse Vest November 2015 Phase 4
NCT02983734 Recruiting Gulf War Illness Boston University October 2015 Phase 2
NCT02582515 Recruiting Tourette Disorder|Chronic Tic Disorder University of California, Los Angeles October 2015 --
NCT02635893 Recruiting Spinal Cord Injury University of Miami|The Craig H. Neilsen Foundation October 2015 Phase 4

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID