Research Area
Product Type
United States ( Change Country )
Tosedostat (CHR2797) Chemical Structure
Ki16425
Ki16425 is a LPA receptor inhibitor with selectivity for LPA1 (Ki = 0.34 μM)and LPA3(Ki = 0.93 μM)vs. LPA2(Ki = 6.5 µM)
LY315920(Varespladib)
LY315920(Varespladib) is a sPLA2 inhibitor (IC50 of 9.6 ±1 nM)
Abiraterone (CB-7598)
Abiraterone (CB-7598) is a potent steroidal cytochrome P450 17alpha-hydroxylase-17,20-lyase (CYP17) inhibitor with an IC50 at 4 nM.
TAK-700 (Orteronel)
Inhibitor of the 17,20 lyase.
Cilostazol
Cilostazol is a medication used in the alleviation of the symptom of intermittent claudication in individuals with peripheral vascular disease.
Isotretinoin
It was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.
Trilostane
Trilostane is an inhibitor of 3 β-hydroxysteroid dehydrogenase used in the treatment of Cushing’s syndrome.
Sildenafil citrate
Sildenafil citrate is an agent used to treat erectile dysfunction and pulmonary arterial hypertension (PAH).
Voriconazole
Voriconazole (VFEND) is a triazole antifungal medication that is generally used to treat serious, invasive fungal infections.
Cilomilast (SB-207499)
Cilomilast (SB-207499) is among the first of a new generation of PDE4 inhibitors (Ki ≈100 nM).
Biological Activity
Tosedostat (CHR2797) is an aminopeptidase inhibitor with IC50 of 100, 150, 220, >1000, >5000, >10000 and >30000 nM for LAP, PuSA, aminopeptidase N, aminopeptidase B, PILSAP, LTA4 hydrolase and MetAP2, respectively.
It has demonstrated anti-tumour activity in a number of models of cancer, both as a single agent and in synergy with cytotoxic agents such as carboplatin and paclitaxel. [1][2]
References on Tosedostat (CHR2797)
- [1] Cancer Res 2008;68:6669-6679
- [2] Clin Cancer Res 2009;15:4978-4985
Product Information
| Molecular Weight (WM): | 406.47 |
|---|---|
| Formula: | C21H30N2O6 |
| CAS No.: | 238750-77-1 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥81mg/mL |
| Water <1mg/mL | |
| Ethanol ≥81mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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Selleck's high quality products have been used in several published research findings, including the following:
Host proteasomal degradation generates amino acids essential for intracellular bacterial growth.
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