Home Transmembrane Transporters NKCC inhibitor Bumetanide For research use only.

Bumetanide

Synonyms: Ro 10-6338，PF 1593

Bumetanide is a loop diuretic of the sulfamyl category to treat heart failure. Bumetanide is a selective Na+-K+-Cl- cotransporter 1 (NKCC1) inhibitor, weakly inhibits NKCC2, with IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively.

Bumetanide Chemical Structure

Bumetanide Chemical Structure

CAS: 28395-03-1

Selleck's Bumetanide has been cited by 1 publication

Purity & Quality Control

Batch: Purity: 99.99%
99.99

Bumetanide Related Products

Choose Selective NKCC Inhibitors

Biological Activity

Description Bumetanide is a loop diuretic of the sulfamyl category to treat heart failure. Bumetanide is a selective Na+-K+-Cl- cotransporter 1 (NKCC1) inhibitor, weakly inhibits NKCC2, with IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05753059 Recruiting
Heart Failure
Yale University|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
 August 10 2023 Phase 1
NCT05323487 Recruiting
Heart Failure
Yale University
 June 1 2022 Not Applicable
NCT02582476 Terminated
Hypokalemic Periodic Paralysis
University College London
 January 2015 Phase 2
NCT00830531 Completed
Seizures
Soul Janet M.D.|Citizens United for Research in Epilepsy|Harvard Catalyst- Harvard Clinical and Translational Science Center|Translational Research Program Boston Children''s Hospital|Charles H. Hood Foundation|National Institute of Neurological Disorders and Stroke (NINDS)|Mooney Family Initiative for Translational Studies in Rare Diseases Boston Children''s Hospital
 January 2010 Phase 1
NCT00930865 Completed
Type 2 Diabetes Mellitus
AstraZeneca|Bristol-Myers Squibb
 July 2009 Phase 1

Chemical Information & Solubility

Molecular Weight 364.42 Formula

C17H20N2O5S
CAS No. 28395-03-1 SDF Download Bumetanide SDF
Smiles CCCCNC1=C(C(=CC(=C1)C(=O)O)S(=O)(=O)N)OC2=CC=CC=C2
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 73 mg/mL ( (200.31 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 12 mg/mL

Water : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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