Catalog No.S1188 Synonyms: ZD-1033
Molecular Weight(MW): 293.37
Anastrozole is a third-generation nonsteroidal selective aromatase inhibitor. It may offer greater selectivity compared with other aromatase inhibitors, being without any intrinsic endocrine effects and with no apparent effect on the synthesis of adrenal steroids.
2 Customer Reviews
Cell viability analysis of BCSCs transduced as in A and treated with Anastrozole or Docetaxel, alone or in combination with BKM120 up to 72 hours. Data are mean ± SD of 3 independent experiments.
Oncotarget, 2016, 7(34):54157-54173. Anastrozole purchased from Selleck.
Expression of ER, PR, Bcl-2 and HER receptors in MCF-7 and AI-resistant cell lines. Western blot analysis of protein expression in AI-resistant cell lines grown under standard conditions with their respective AI and MCF-7 cells grown with 1% FCS or grown with 10% NCS + 10−7 M testosterone for 21 weeks. β-actin was used as loading control.
Int J Oncol, 2015, 46(4):1481-90. . Anastrozole purchased from Selleck.
Purity & Quality Control
Choose Selective Aromatase Inhibitors
|Description||Anastrozole is a third-generation nonsteroidal selective aromatase inhibitor. It may offer greater selectivity compared with other aromatase inhibitors, being without any intrinsic endocrine effects and with no apparent effect on the synthesis of adrenal steroids.|
Anastrozole has high intrinsic potency in vitro and inhibits human placental aromatase with an IC50 of 15 nM. Anastrozole it is 200 times as potent as AG, twice as potent as 4-OHA and one third as potent as fadrozole. . Anastrozole inhibits aromatase by binding competitively to the hem group of the CYP unit of the enzyme thereby reducing estrogen biosynthesis in the periphery and the breast. Anastrozole has little or no effect on other steroid hormones. 
|In vivo||Anastrozole (0.1 mg/kg) given orally to mature rats on Day 2 or 3 of the estrous cycle, blocked ovulation in mature females; in pubertal rats, the same dose given for 3 days completely blocks androstenedione-stimulated uterine development. These effects may be attributes to inhibition of the normal preovulatory rise in ovarian follicular estrogen synthesis in mature females and to inhibition of metabolism of the exogenous androstenedione by the immature ovary in prepubertal females. Twice-daily administration of >9.1 mg/kg of Anastrozole given orally to male pigtailed monkeys inhibits peripheral aromatase, thereby reducing circulating estradiol concentrations by 50% to 60%. |
|In vitro||DMSO||59 mg/mL (201.11 mM)|
|Ethanol||59 mg/mL (201.11 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02204098||Recruiting||Breast Cancer|Breast Carcinoma|Malignant Neoplasm of Breast||Washington University School of Medicine|National Cancer Institute (NCI)|The Rising Tide Foundations for Clinical Cancer Research||January 7 2015||Phase 1|
|NCT02291913||Active not recruiting||Breast Cancer||SCRI Development Innovations LLC|Novartis||January 7 2015||Phase 2|
|NCT00310180||Active not recruiting||Breast Adenocarcinoma|Estrogen Receptor and/or Progesterone Receptor Positive|HER2/Neu Negative|Stage IA Breast Cancer AJCC v7|Stage IB Breast Cancer AJCC v7|Stage IIA Breast Cancer AJCC v6 and v7|Stage IIB Breast Cancer AJCC v6 and v7|Stage IIIB Breast Cancer AJCC v7||National Cancer Institute (NCI)|American College of Surgeons|Cancer and Leukemia Group B|NSABP Foundation Inc|NCIC Clinical Trials Group|North Central Cancer Treatment Group|Southwest Oncology Group||April 7 2006||Phase 3|
|NCT03024580||Recruiting||Breast Neoplasm||Instituto Nacional de Cancer Brazil|Cancer Research UK Cambridge Institute||March 6 2017||Phase 2|
|NCT03219476||Recruiting||Breast Cancer|Invasive Breast Cancer||Medical College of Wisconsin||February 5 2017||Phase 2|
|NCT03099174||Recruiting||Neoplasms|Breast Neoplasms||Boehringer Ingelheim||May 4 2017||Phase 1|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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