Home Neuronal Signaling Adenosine Kinase inhibitor 5-Iodotubercidin For research use only.

5-Iodotubercidin

Synonyms: NSC 113939, 5-ITu

5-Iodotubercidin (NSC 113939, 5-ITu) is a potent adenosine kinase inhibitor with IC50 of 26 nM. It inhibits nucleoside transporter, CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC.

5-Iodotubercidin Chemical Structure

5-Iodotubercidin Chemical Structure

CAS: 24386-93-4

Selleck's 5-Iodotubercidin has been cited by 4 publications

Purity & Quality Control

Batch: Purity: 99.9%
99.9

5-Iodotubercidin Related Products

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Biological Activity

Description 5-Iodotubercidin (NSC 113939, 5-ITu) is a potent adenosine kinase inhibitor with IC50 of 26 nM. It inhibits nucleoside transporter, CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC.
Targets
adenosine kinase [1]
In vitro
In vitro 5-Iodotubercidin(Itu) is a genotoxic drug that activates the Atm-p53 pathway and has anti-tumor activity. Itu is unique compared to other nucleoside analogs in the way that it induces G2 arrest in a p53 -dependent manner. Moreover, at higher doses, Itu might activate p53-independent pathways, which may cooperate with p53 to kill cells and inhibit tumor growth. Incorporation of Itu metabolite into DNA causes DNA breaks, which triggers the DNA damage response. Itu might be a potential chemotherapeutic drug with distinct working mechanisms[2].
Experimental Result Images Methods Biomarkers Images PMID
Western blot A1 receptor p-p53 / p53 / p-ATM / ATM / p-Chk2 / Chk2 25354767
Immunofluorescence AURKA / pAURKA 27562071
In Vivo
In vivo 5-Iodotubercidin is a potent inhibitor of adenosine kinase in the rat brain. 5-iodotubercidin has potent hypotensive, muscle relaxant, and hypothermic actions in mice, and that these effects could be blocked by theophylline, an adenosine receptor antagonist. 5-iodotubercidin (1 mg/kg, i.p.) administered prior to an ischemic episode, fails to provide a degree of cerebroprotection, assessed either by locomotor or histopathological indices Even though 5-iodotubercidin administration is known to enhance extracellular adenosine levels in brain slices[1].
Animal Research Animal Models Male Mongolian gerbils
Dosages 1, 2.5 and 5 mg/kg
Administration i.p.

Chemical Information & Solubility

Molecular Weight 392.15 Formula

C11H13IN4O4
CAS No. 24386-93-4 SDF Download 5-Iodotubercidin SDF
Smiles C1=C(C2=C(N=CN=C2N1C3C(C(C(O3)CO)O)O)N)I
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 78 mg/mL ( (198.9 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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