PAFR

Inhibitory Selectivity

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Notes:
2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Catalog No. Information Product Use Citations Product Validations
S7238

NVP-TNKS656

NVP-TNKS656 is a highly potent, selective, and orally active tankyrase inhibitor with IC50 of 6 nM for TNKS2, > 300-fold selectivity against PARP1 and PARP2.

S1343

Ginkgolide B

Ginkgolide B is a PAFR antagonist with IC50 of 3.6 μM.

Catalog No. Information Product Use Citations Product Validations
S7238

NVP-TNKS656

NVP-TNKS656 is a highly potent, selective, and orally active tankyrase inhibitor with IC50 of 6 nM for TNKS2, > 300-fold selectivity against PARP1 and PARP2.

Catalog No. Information Product Use Citations Product Validations
S1343

Ginkgolide B

Ginkgolide B is a PAFR antagonist with IC50 of 3.6 μM.

2015, 10.1007/s12035-015-9263-6