AMPK

  • Compare AMPK Products
  • Research Area

AMPK Inhibitors | Activators (8)

water-soluble

Cat.No. Product Name Information Product Use Citation Customer Product Validation
S2697 A-769662 A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM in cell-free assays, little effect on GPPase/FBPase activity.
  • Autophagy, 2016, 12(2):432-8
  • Cancer Res, 2014, 74(1):298-308
  • J Lipid Res, 2014, 55(7):1254-1266
S1802 AICAR (Acadesine) AICAR (Acadesine) results in accumulation of ZMP, which mimics the stimulating effect of AMP on AMPK and AMPK kinase. Phase 3.
  • Br J Pharmacol, 2015, 10.1111/bph.13120
  • Br J Cancer, 2014, 111(8):1562-71
S7306 Dorsomorphin 2HCl Dorsomorphin 2HCl is a potent, reversible, selective AMPK inhibitor with Ki of 109 nM in cell-free assays, exhibiting no significant inhibition of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, and JAK3. Also inhibits type Ⅰ BMP receptor activity.
  • Autophagy, 2016, 12(2):432-8
  • Mol Brain, 2015, 08:20
  • FEBS Lett, 2015, 10.1016/j.febslet.2015.05.020
S2542 Phenformin HCl Phenformin HCl is a hydrochloride salt of phenformin that is an anti-diabetic drug from the biguanide class.
S7317 WZ4003 WZ4003 is a highly specific NUAK kinase inhibitor with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2 in cell-base assays, respectively, without significant inhibition on 139 other kinases.
S7898 GSK621 GSK621 is a specific and potent AMPK activator.
S7318 HTH-01-015 HTH-01-015 is a potent and selective NUAK1 inhibitor with IC50 of 100 nM, >100-fold selectivity over NUAK2.
S7840 Dorsomorphin Dorsomorphin is a potent, reversible, selective AMPK inhibitor with Ki of 109 nM in cell-free assays, exhibiting no significant inhibition of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, and JAK3. Also inhibits type I BMP receptor activity.
  • Autophagy, 2016, 12(2):432-8
  • PLoS One, 2015, 10(4):e0124562
  • Clinical and Experimental Pharmacology and Physiology, 2016, 43(1):125-34

Hover Mouse over '+' to display IC50

Cat.No. Product Name Solubility (25°C)
Water DMSO Ethanol
S2697 A-769662 <1 mg/mL 72 mg/mL <1 mg/mL
S1802 AICAR (Acadesine) <1 mg/mL 51 mg/mL <1 mg/mL
S7306 Dorsomorphin 2HCl 94 mg/mL <1 mg/mL <1 mg/mL
S2542 Phenformin HCl 48 mg/mL 48 mg/mL 12 mg/mL
S7317 WZ4003 <1 mg/mL 7 mg/mL <1 mg/mL
S7898 GSK621 <1 mg/mL 97 mg/mL <1 mg/mL
S7318 HTH-01-015 <1 mg/mL 58 mg/mL 30 mg/mL
S7840 Dorsomorphin <1 mg/mL 3 mg/mL 2 mg/mL
Contact Us