Home PI3K/Akt/mTOR AMPK

AMPK Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S7306 Dorsomorphin Dihydrochloride Dorsomorphin 2HCl is a potent, reversible, selective AMPK inhibitor with Ki of 109 nM in cell-free assays, exhibiting no significant inhibition of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, and JAK3. Also inhibits type Ⅰ BMP receptor activity. Dorsomorphin induces autophagy in cancer cell line.
J Clin Invest, 2025, e190215
Redox Biol, 2025, 81:103532
Redox Biol, 2025, 82:103606
Verified customer review of Dorsomorphin Dihydrochloride
S7840 Dorsomorphin (Compound C) Dorsomorphin is a potent, reversible, selective AMPK inhibitor with Ki of 109 nM in cell-free assays, exhibiting no significant inhibition of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, and JAK3. Dorsomorphin selectively inhibits the BMP type I receptors ALK2, ALK3 and ALK6. Dorsomorphin is used in promoting specific cell differentiation and inducing cancer cell line autophagy. For cell testing, the water-soluble S7306 Dorsomorphin (Compound C) 2HCl is recommended.
Nucleic Acids Res, 2025, 53(22)gkaf1397
Theranostics, 2025, 15(12):5931-5952
EMBO Mol Med, 2025, 17(10):2735-2761
Verified customer review of Dorsomorphin (Compound C)
S7317 WZ4003 WZ4003 is a highly specific NUAK kinase inhibitor with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2 in cell-base assays, respectively, without significant inhibition on 139 other kinases.
Cell Rep, 2024, 43(7):114446
Int J Mol Sci, 2024, 25(3):1411.
Int J Mol Sci, 2024, 25(3)1411
Verified customer review of WZ4003
S9833 BAY-3827 BAY-3827 is a potent AMPK inhibitor which inhibits AMPK kinase activity with IC50 values of 1.4 nM at a low, 10 μM ATP concentration and 15 nM at a high, 2 mM ATP concentration.
Int J Mol Sci, 2025, 26(15)7624
Mol Neurobiol, 2025, 62(10):13786-13806
Autophagy, 2024, 1-24.
S7318 HTH-01-015 HTH-01-015 is a potent and selective NUAK1 inhibitor with IC50 of 100 nM, >100-fold selectivity over NUAK2.
Mol Cell, 2020, 77(6):1322-1339
Cell Chem Biol, 2019, 10.1016/j.chembiol.2019.10.005
Breast Cancer Res, 2018, 20(1):22
Verified customer review of HTH-01-015
E3652 Rehmanniae radix praeparata Extract Rehmanniae radix praeparata Extract is extracted from Rehmanniae radix praeparata, which can improve diabetes through AMPK-mediated NF-κB/NLRP3 signaling pathway.
E2818 MARK4 inhibitor 1 MARK4 inhibitor 1 is a potent microtubule affinity-regulating kinase 4 (MARK4) inhibitor, with an IC50 of 1.54 μM for MARK4 inhibition assay.
E0022 Ophiopogonin D Ophiopogonin D (OJV-VI, Deacetylophiopogonin C) is a steroidal glycoside isolated from Chinese herb Radix ophiopogonis and shows anti-tumor property. This compound could suppress TGF-β1-mediated metastatic behavior of MDA-MB-231 cells by regulating ITGB1/FAK/Src/AKT/β-catenin/MMP-9 signaling axis. It also attenuates PM2.5-induced inflammation via suppressing the AMPK/NF-κB pathway in mouse pulmonary epithelial cells.
S0177 XMD-17-51 XMD-17-51 (XMD17-51) is a potent and highly selective inhibitor of NUAK1.
E3029 White Paeony Root Extract White Paeony Root Extract is extracted from Paeonia lactiflora Pall., which can alleviate liver injury in hypercholesterolemic rats through the ROCK/AMPK pathway.
S1208 Doxorubicin (Adriamycin) Hydrochloride Doxorubicin (DOX) HCl is an antibiotic agent that inhibits human DNA topoisomerase II with IC50 of 2.67 μM. Doxorubicin reduces basal phosphorylation of AMPK. Doxorubicin is used in the concomitant treatment of HIV-infected patients but is found to be at high risk of HBV reactivation.This product may precipitate when dissolved in PBS solution. It is recommended to prepare the stock solution in pure water and dilute with either pure water or saline to obtain the working solution.Doxorubicin (Adriamycin) HCl can be used to induce animal models of kidney disease.
Cell Res, 2025, 35(6):437-452.
Nat Commun, 2025, 16(1):8873
Nat Commun, 2025, 16(1):509
Verified customer review of Doxorubicin (Adriamycin) Hydrochloride
S1113 GSK690693 GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM in cell-free assays, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. GSK690693 also potently inhibits AMPK and DAPK3 from the CAMK family with IC50 of 50 nM and 81 nM, respectively. GSK690693 affects Unc-51-like autophagy activating kinase 1 (ULK1) activity, robustly inhibits STING-dependent IRF3 activation. Phase 1.
Theranostics, 2025, 15(18):9819-9837
Cell Rep, 2025, 44(7):115947
Front Cell Infect Microbiol, 2025, 15:1543186
Verified customer review of GSK690693
S8274 STO-609 STO-609 is a specific inhibitor of the Ca2+/Calmodulin-dependent protein kinase kinase(CaM-KK) that inhibits the activities of recombinant CaM-KKα and CaM-KKβ isoforms, with Ki values of 80 and 15 ng/ml, respectively, and also inhibits their autophosphorylation activities. This compound inhibits AMPKK activity and inhibits autophagy.
Redox Rep, 2025, 30(1):2447721
PLoS One, 2025, 20(8):e0330282
Cell Genom, 2025, 5(3):100782
S8161 ON123300 ON123300 is a potent and multi-targeted kinase inhibitor with IC50 of 3.9 nM, 5 nM, 26 nM, 26 nM, 9.2 nM and 11nM for CDK4, Ark5/NUAK1, PDGFRβ, FGFR1, RET (c-RET), and Fyn, respectively.
Cell Rep Med, 2025, S2666-3791(25)00231-9
Cell Rep, 2024, 43(7):114446
J Cell Sci, 2021, jcs.258685