Research Area
Product Type
Gamma-Secretase Inhibitors
- Cat.No
- Product Name
- Information
- Publications
- Customer Reviews
- S1575
- RO4929097
- RO4929097 is a potent and selective inhibitor of γ secretase (GS) with IC50 of 4 nM.
(0)
(0)
- S1262
- BMS-708163
- BMS-708163 is a γ-secretase inhibitor (GSI) (IC50 =0.3 nM)
- (0)
- (0)
- S2215
- DAPT (GSI-IX)
- DAPT (GSI-IX) is a γ-secretase inhibitor with IC50 of 0.12 and 0.2 μM for total Aβ and Aβ42 levels, respectively.
- (0)
- (0)
- S1594
- Semagacestat (LY450139)
- Semagacestat (LY450139) is a γ-secretase blocker of Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. Semagacestat also inhibits Notch signaling with IC50 of 14.1 nM.
- (0)
- (0)
- S2660
- MK-0752
- MK-0752 is a potent gamma secretase (γ-secretase) inhibitor in clinical development with an IC50 of 5 nM for Aβ40 in human SH-SY5Y cells.
- (0)
- (0)
- S2711
- YO-01027
- YO-01027 is a dipeptidic gamma-secretase inhibitor with IC50 of 2.6 and 2.9 nM for the proteolysis of APPL and Notch, respectively.
- (0)
- (0)
S2714- LY-411575
- LY-411575 is a selective, cell permeable, small molecule gamma secretase inhibitor with an IC50 of 0.1 nM for APP23 and APP51/16 primary neurons.
- (0)
- (0)