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Gamma-Secretase Inhibitors

  • Cat.No
  • Product Name
  • Information
  • Publications
  • Customer Reviews
  • S1575
  • RO4929097
  • RO4929097 is a potent and selective inhibitor of γ secretase (GS) with IC50 of 4 nM.
  • 0 Reference(s) (0)
  • (0)Review(s) (0)
  • S1262
  • BMS-708163
  • BMS-708163 is a γ-secretase inhibitor (GSI) (IC50 =0.3 nM)
  • 0 Reference(s) (0)
  • (0)Review(s) (0)
  • S2215
  • DAPT (GSI-IX)
  • DAPT (GSI-IX) is a γ-secretase inhibitor with IC50 of 0.12 and 0.2 μM for total Aβ and Aβ42 levels, respectively.
  • 0 Reference(s) (0)
  • (0)Review(s) (0)
  • S1594
  • Semagacestat (LY450139)
  • Semagacestat (LY450139) is a γ-secretase blocker of Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. Semagacestat also inhibits Notch signaling with IC50 of 14.1 nM.
  • 0 Reference(s) (0)
  • (0)Review(s) (0)
  • S2660
  • MK-0752
  • MK-0752 is a potent gamma secretase (γ-secretase) inhibitor in clinical development with an IC50 of 5 nM for Aβ40 in human SH-SY5Y cells.
  • 0 Reference(s) (0)
  • (0)Review(s) (0)
  • S2711
  • YO-01027
  • YO-01027 is a dipeptidic gamma-secretase inhibitor with IC50 of 2.6 and 2.9 nM for the proteolysis of APPL and Notch, respectively.
  • 0 Reference(s) (0)
  • (0)Review(s) (0)
  • water-soluble S2714
  • LY-411575
  • LY-411575 is a selective, cell permeable, small molecule gamma secretase inhibitor with an IC50 of 0.1 nM for APP23 and APP51/16 primary neurons.
  • 0 Reference(s) (0)
  • (0)Review(s) (0)