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S1250
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MDV3100 (Enzalutamide) |
MDV3100 is an androgen-receptor (AR) antagonist with IC50 of 36 nM. |
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S2246
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Abiraterone Acetate (CB7630) |
Abiraterone acetate (CB7630, CB 7630, CB-7630) is an acetate salt form of Abiraterone which is a steroidal cytochrome CYP17 inhibitor with IC50 of 72 nM. |
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S1190
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Bicalutamide (Casodex) |
Bicalutamide (Casodex, Cosudex, Calutide, Kalumid) is an androgen receptor (AR) antagonist with IC50 of 0.16 μM. |
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S1123
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Abiraterone (CB-7598) |
Abiraterone (CB-7598) is a potent CYP17 inhibitor with IC50 of 2 nM. |
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S2187
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Avasimibe(CI-1011) |
Avasimibe inhibits ACAT and CYP2C9 with IC50 of 3.3 μM and 2.9 μM, respectively. |
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S2921
|
PF-4981517 |
PF-4981517 is a potent and selective inhibitor of CYP3A4 (P450) with IC50 of 0.03 μM. |
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S1442
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Voriconazole |
Voriconazole (VFEND) is a triazole antifungal medication that is generally used to treat serious, invasive fungal infections. |
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S1353
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Ketoconazole |
Ketoconazole inhibits cyclosporine oxidase and testosterone 6 beta-hydroxylase with IC50 of 0.19 mM and 0.22 mM, respectively. |
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S2900
|
Cobicistat (GS-9350) |
Cobicistat (GS-9350) is a potent and selective inhibitor of CYP3A with IC50 of 30-285 nM. |
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S2803
|
Galeterone (TOK-001) |
Galeterone (TOK-001, VN/124-1) is a selective CYP17 inhibitor and androgen receptor (AR) antagonist with IC50 of 300 nM and 384 nM, respectively. |
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S2757
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TH-302 |
TH-302 is selective hypoxia-activated prodrug targeting hypoxic regions of solid tumors with IC50 of 19 nM. |
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S2042
|
Cyproterone acetate |
Cyproterone acetate is an androgen receptor (AR) antagonist with IC50 of 7.1 nM. |
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S2046
|
Pioglitazone HCl (Actos) |
Pioglitazone hydrochloride (Actos) is a hydrochloride salt form of pioglitazone which is a cytochrome P450 (CYP)2C8 and CYP3A4 enzymes inhibitor for CYP2C8, CYP3A4 and CYP2C9 with Ki of 1.7 μM, 11.8 μM and 32.1 μM, respectively.
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S2555
|
Clarithromycin (Biaxin, Klacid) |
Clarithromycin (Biaxin, Klacid) is a macrolide antibiotic and a CYP3A4 substrate and inhibitor. |
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S2526
|
Alizarin |
Alizarin strongly inhibits P450 isoform CYP1A1, CYP1A2 and CYP1B1 with IC50 of 6.2 μM, 10.0 μM and 2.7 μM, respectively. |
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S1908
|
Flutamide (Eulexin) |
Flutamide (Eulexin) is an oral nonsteroidal antiandrogen agent primarily used to treat prostate cancer. |
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S1195
|
TAK-700 (Orteronel) |
TAK-700 (Orteronel) is a potent and highly selective rat and human 17,20-lyase inhibitor with IC50 of 54 nM and 38 nM, respectively. |
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