Pancuronium dibromide

Pancuronium dibromide is a competitive nicotinic acetylcholine receptor antagonist, used as a muscle relaxant.

Pancuronium dibromide Chemical Structure

Pancuronium dibromide Chemical Structure

CAS: 15500-66-0

Selleck's Pancuronium dibromide has been cited by 6 publications

Purity & Quality Control

Batch: Purity: 99.97%
99.97

Pancuronium dibromide Related Products

Signaling Pathway

Choose Selective AChR Inhibitors

Biological Activity

Description Pancuronium dibromide is a competitive nicotinic acetylcholine receptor antagonist, used as a muscle relaxant.
Targets
AChR [1]
In vitro
In vitro

Pancuronium results in open channel block of embryonic-type nicotinic acetylcholine receptor channels after coapplication of blocker and acetylcholine, characterized by decrease of the time constant of current decay. Pancuronium also results in competitive block of embryonic-type nicotinic acetylcholine receptor channels. [1] Pancuronium increases heart rate, vecuronium and rocuronium produces positive inotropic effects, and vecuronium shortens refractoriness in isolated rat atria.  [2] Pancuronium (0.5 mM) induces a complete fade of the tetanic contraction while leaving the twitch unaffected in the extensor digitorum longus muscle of the rat. Pancuronium decreases the amplitude and increases the tetanic rundown of trains of endplate potentials (e.p.ps) evoked in the frequency of 50 Hz in the extensor digitorum longus muscle of the rat.[3]

In Vivo
In vivo

Pancuronium decreases tidal volume (VT) and minute ventilation (VE) in high dose dogs by 82%. Pancuronium decreases tidal volume (VT) and minute ventilation (VE) in low dose dogs by 40% and 55%. [4] Pancuronium limits cerebral hyperemia during prolonged seizures by attenuating increases in blood pressure as a result of elimination of skeletal muscle activity in newborn pigs. [5] Pancuronium results in a significant difference with control is observed at gallamine concentrations ranging from 0.032-0.32 mM  in tracheal smooth muscle strips from guinea-pigs.[6]

Chemical Information & Solubility

Molecular Weight 732.67 Formula

C35H60N2O4.2Br

CAS No. 15500-66-0 SDF Download Pancuronium dibromide SDF
Smiles CC(=O)OC1CC2CCC3C(C2(CC1[N+]4(CCCCC4)C)C)CCC5(C3CC(C5OC(=O)C)[N+]6(CCCCC6)C)C.[Br-].[Br-]
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (136.48 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : 100 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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