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AChR Antagonists

Cat.No. Product Name Information Product Use Citations Product Validations
S2497 Pancuronium dibromide Pancuronium dibromide is a competitive nicotinic acetylcholine receptor antagonist, used as a muscle relaxant.
Nat Commun, 2025, 16(1):7764
J Immunother Cancer, 2024, 12(11)e009805
Imaging Neurosci (Camb), 2024, 2imag-2-00314
S2508 Scopolamine (LSM-4015) HBr Scopolamine HBr (LSM-4015,NSC 61806,(-)-Scopolamine hydrobromide, Hyoscine hydrobromide, Scopine hydrobromide) is a competitive muscarinic acetylcholine receptor antagonist with an IC50 of 55.3 nM.
Heliyon, 2024, 10(1):e23945
Zool Res, 2023, 44(4):712-724
Exp Ther Med, 2020, 20(4):3625-3632
S1978 Methscopolamine Methscopolamine is a muscarinic acetylcholine receptor blocker.
Mol Brain, 2021, 14(1):113
Mol Neurobiol, 2020, 10.1007/s12035-020-02175-y
Neuropharmacology, 2019, 146:252-263
S3144 Darifenacin HBr Darifenacin HBr (UK-88525) is a selective M3 muscarinic receptor antagonist with pKi of 8.9.
AAPS PharmSciTech, 2024, 25(7):204
World J Gastroenterol, 2023, 29(20):3103-3118
JCI Insight, 2017, 2(3):e89780
S1683 Ipratropium Bromide Ipratropium Bromide is an antagonist of M3 type muscarinic acetylcholine receptors, used for the treatment of chronic obstructive pulmonary disease (COPD).
Int Forum Allergy Rhinol, 2020, 10(2):233-242
Anal Chem, 2019, 91(18):11888-11896
S2549 Trospium chloride Trospium chloride is a competitive muscarinic cholinergic receptor antagonist.
J Immunother Cancer, 2024, 12(11)e009805
FEBS Lett, 2020, 10.1002/1873-3468.14015
S4713 Atropine Atropine (Atropen, Atnaa, Tropine tropate, DL-Hyoscyamine) is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with anti-myopia effect.
Front Mol Biosci, 2024, 11:1423351
iScience, 2023, 26(3):106241
S1754 Oxybutynin Oxybutynin is a competitive antagonist of the M1, M2, and M3 subtypes of the muscarinic acetylcholine receptor, used to relieve urinary and bladder difficulties.
bioRxiv, 2023, 10.1101/2023.03.08.531806
S3048 Solifenacin succinate Solifenacin succinate (YM905) is a urinary antispasmodic of the antimuscarinic class.
J Immunother Cancer, 2024, 12(11)e009805
S4024 Homatropine Methylbromide Homatropine Methylbromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.
Nature, 2018, 560(7718):372-376
S4027 Flavoxate HCl Flavoxate (NSC-114649) is a muscarinic AChR antagonist with IC50 of 12.2 μM.
Cancer Res Commun, 2025, 10.1158/2767-9764.CRC-24-0433
S9326 Scopolamine Scopolamine (Skopolamin) is a tropane alkaloid derived from plants of the nightshade family, specifically Hyoscyamus niger and Atropa belladonna, with anticholinergic, antiemetic and antivertigo properties.
Immunity, 2024, 57(2):364-378.e9
E7262 Darifenacin Darifenacin (UK-88525) is a selective and orally active antagonist of M3 muscarinic receptor (M3R) with a pKi of 8.86. It exhibits efficacy in overactive bladder, partly due to bladder afferent desensitization. It also shows potential in preventing liver injury and inhibiting colorectal cancer growth in both in vitro and in vivo models.
World J Gastroenterol, 2023, 29(20):3103-3118
S4660 Glycopyrrolate Glycopyrrolate (Glycopyrronium, Robinul, Gastrodyn) is a muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anesthetics.
J Clin Med, 2022, 11(9)2307
S3117 Oxybutynin hydrochloride Oxybutynin(MJ4309-1) is an anticholinergic medication used to relieve urinary and bladder difficulties.
Environ Toxicol Chem, 2021, 10.1002/etc.5018
S2547 Tiotropium Bromide hydrate Tiotropium Bromide hydrate (BA 679BR) is a monohydrate of tiotropium bromide (Spiriva; Tiova; BA 679BR; tiopropium) that is an anticholinergic and bronchodilator and a muscarinic receptor antagonist.
S5873 Scopolamine HBr trihydrate Scopolamine HBr is a competitive muscarinic acetylcholine receptor antagonist with an IC50 of 55.3 nM.
S9847New Methyllycaconitine citrate (MLA) Methyllycaconitine citrate (MLA), the citrate salt of Methyllycaconitine, is a norditerpenoid alkaloid isolated from Delphinium brownii seeds. It acts as a selective antagonist of the α7 neuronal nicotinic acetylcholine receptor (α7nAChR) and exhibits potential as a drug candidate for Alzheimer’s disease treatment.
S0032 Batefenterol  Batefenterol (GSK961081, TD-5959) is both a muscarinic receptor antagonist and a β2-adrenoceptor agonist with Ki of 1.4 nM, 1.3 nM and 3.7 nM for hM2, hM3 muscarinic receptors and hβ2-adrenoceptor, respectively.
S5480 Clidinium Bromide Clidinium Bromide(Ro 2-3773) is an anticholinergic drug.
S6985 Varenicline Varenicline(CP 526555) is highly selective and blocks more potently to α4β2 receptors than to other common nicotinic receptors (>500-fold α3β4, >3,500-fold α7, >20,000-fold α1βγδ), or to non-nicotinic receptors and transporters (>2,000-fold). This compound also acts as an agonist of 5-HT3 serotonine receptors.
S4025 Homatropine Bromide Homatropine Bromide is an muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.
S5238 Solifenacin (YM905) Solifenacin (YM905) is a competitive muscarinic receptor antagonist. The binding of acetylcholine to these receptors, particularly the M3 receptor subtype, plays a critical role in the contraction of smooth muscle.
S5258 Revefenacin Revefenacin (TD-4208, GSK-1160724) is a potent, lung-selective, long-acting muscarinic antagonist that may be for the treatment of respiratory disease.
S2054 Orphenadrine Citrate Orphenadrine Citrate is a skeletal muscle relaxant, it acts in the central nervous system to produce its muscle relaxant effects.
E6073New Solifenacin hydrochloride Solifenacin hydrochloride (YM905 hydrochloride) is an antagonist of muscarinic receptor used for the treatment of overactive bladder. It exhibits pKi values of approximately 7.6, 6.9, and 8.0 for the M1, M2, and M3 muscarinic receptors, respectively, in radioligand binding assays.
S4034 Diphemanil Methylsulfate Diphemanil Methylsulfate is a quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors (mAchR).
E6020 (±)-Darifenacin Darifenacin [(±)-UK-88525] is a potent, specific and competitive M3 selective receptor antagonist (M3 SRA) that has been shown to have high affinity and selectivity for the M3 receptor. It significantly improves major overactive bladder (OAB) symptoms with proven efficacy, tolerability, and safety.
S4143 Pentoxyverine Citrate Pentoxyverine Citrate (Carbetapentane) is an antitussive (cough suppressant) commonly used for cough associated with illnesses like common cold.
E3116 Acanthopanax Senticosus Extract Acanthopanax Senticosus Extract is obtained from Acanthopanax Senticosus, which exhibits dual effects of contraction via muscarinic ACh receptors (mAChRs) and direct relaxation on mouse ileal function, and its relaxant effect could be useful in treating diarrhea symptoms, resulting in an increase in the parasympathetic nerve activities.
S5777 Ipratropium bromide monohydrate Ipratropium bromide (Atrovent, Sch 1000) monohydrate is an antagonist of muscarinic acetylcholine receptors (mAChR) with IC50 of 2.9 nM, 2.0 nM, and 1.7 nM for M1, M2, and M3 receptors, respectively.
S9459 Mecamylamine Hydrochloride Mecamylamine hydrochloride is an orally active, nonselective, noncompetitive nAChR(nicotinic acetylcholine receptors) antagonist.It is also a ganglionic blocker and can across the blood-brain barrier. It can be used in the research of neuropsychiatric disorders, hypertension, antidepressant area.
E0829 Nitrocaramiphen hydrochloride Nitrocaramiphen hydrochloride is an antagonist of muscarinic acetylcholine receptor M1 (mAChR M1), which can completely remove the hyperpolarizing effect of muscarine.
S3701 Benactyzine hydrochloride Benactyzine hydrochloride is a centrally acting muscarinic antagonist. It is used as an antidepressant in the treatment of depression and associated anxiety.
S5699 Scopolamine N-Oxide HydrobroMide Monohydrate Scopolamine N-Oxide (Hyoscine N-oxide, Genoscopolamine) is a muscarinic antagonist used to study binding characteristics of muscarinic cholinergic receptors.
S4623 Methylbenactyzine Bromide Methylbenactyzine Bromide (Gastrimade, Noinarin, Paragone, Semulgin) is a kind of muscarinic cholinergic receptor antagonist with antispasmodic activity.
S4069 Hexamethonium Dibromide Hexamethonium Dibromide is a selective antagonist of neuronal-type nicotinic AChR in ganglia.
S3735 Umeclidinium bromide Umeclidinium bromide(GSK573719A) is a long-acting muscarinic antagonist approved for the maintenance treatment of chronic obstructive pulmonary disease (COPD).
S4834 Propantheline bromide Propantheline bromide (Pro-Banthine, Neometantyl, Neopepulsan) is a muscarinic antagonist used to treat gastrointestinal conditions associated with intestinal spasm and to decrease secretions during anesthesia.
S4992 Nanofin Nanofin (2,6-Dimethylpiperidine, Lupetidine, Naniopinum) is a ganglion blocker alkaloid having nicotinic acetylcholine receptor antagonist action. It has antihypertensive effect used for mild to moderate hypertension.
S3298 Caulophylline (N-Methylcytisine) Caulophylline (N-Methylcytisine, Caulophyllin, NMC) is a tricyclic quinolizidine alkaloid with anti-inflammatory activities. It binds to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia with Kd of 50 nM. This compound significantly reduces myeloperoxidase (MPO) activity and blocks the activation of NF-κB by inhibiting IκB and IKK phosphorylation.
S5921 Cyclopentolate Hydrochloride Cyclopentolate is an antagonist of muscarinic acetylcholine receptors with Ki values of 1.62, 27.5, and 2.63 nM for M1, M2, and M3 receptors, respectively.
S4292 Diphenidol HCl Diphenidol HCl(Diphenidol hydrochloride) is a potent antagonist of muscarinic M2 and M3 receptor with pKb of 6.72 and 7.02, respectively, used in the treatment of vomiting and vertigo.
S1913 Tropicamide Tropicamide(Ro 1-7683) is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist with IC50 of 8.0 nM.
S2130 Atropine sulfate monohydrate Atropine sulfate monohydrate is a competitive antagonist for the muscarinic acetylcholine receptor, used to decrease the production of saliva and secretions of the airway prior to surgery.
Neurosci Bull, 2023, none
Neurochem Res, 2020, 10.1007/s11064-020-03103-1
S5538 Tropisetron Tropisetron (ICS 205-930) is a 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.
Chin Med, 2024, 19(1):87
Neural Regen Res, 2023, 18(9):2019-2028
S4931 Propiverine hydrochloride Propiverine is an anticholinergic drug used for the treatment of overactive bladder and urinary incontinence. Propiverine is a muscarinic receptor antagonist possessing additional properties, i.e., block of L-type Ca2+ channels.
S6469 Thonzylamine Thonzylamine (Neohetramine) is an antihistamine and anticholinergic drug.