Home GPCR & G Protein cAMP inhibitor PACAP 1-27

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PACAP 1-27 cAMP inhibitor

Cat.No.S8414

Pituitary adenylate cyclase activating polypeptide (PACAP 1-27) is a potent PACAP receptor antagonist.
PACAP 1-27 cAMP inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 3147.61

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Quality Control

Batch: Purity: 99.52%
99.52

Solubility

In vitro
Batch:

Water : 100 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

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In vivo
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Chemical Information, Storage & Stability

Molecular Weight 3147.61 Formula

C142H224N40O39S

 Storage (From the date of receipt)
CAS No. 127317-03-7 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles CCC(C)C(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)O)C(=O)NC(CC(=O)O)C(=O)NC(CO)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC3=CC=C(C=C3)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CCC(=O)N)C(=O)NC(CCSC)C(=O)NC(C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(C)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)N)NC(=O)CNC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(CC5=CNC=N5)N

Mechanism of Action

Targets/IC50/Ki
PACAP receptor
In vitro
PACAP27(100 nM) inhibits all Tat-mediated toxic effects including DNA DSBs, and it prevents the induction of neuronal loss induced by Tat(transactivator of transcription). PACAP27, through CCL5, mitigates the effects of Tat-induced neuronal dysfunction exerting its neuroprotective effect. PACAP-27 (EC50=10nM) stimulates glibenclamide-sensitive and DIDS-insensitive iodide efflux in Calu-3 cells.
In vivo
PACAP-27 is potent VIP-like vasodilators of the femoral arterial bed in dogs. In the cardiovascular system, PACAP27 has vasodepressor actions similar to VIP in anesthetized rats. Intra-arterial infusion of PACAP27 induces dose-related increases in peak femoral arterial flow.
References
  • [4] https://pubmed.ncbi.nlm.nih.gov/24696163/
  • [5] https://pubmed.ncbi.nlm.nih.gov/14744818/

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