Adenosine Receptor

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S2790 Istradefylline <1 mg/mL 6 mg/mL <1 mg/mL
S2153 CGS 21680 HCl <1 mg/mL 100 mg/mL <1 mg/mL
S1647 Adenosine <1 mg/mL 12 mg/mL <1 mg/mL
S8575 A2AR antagonist 1 <1 mg/mL 61 mg/mL <1 mg/mL
S4932 Proxyphylline -1 mg/mL 47 mg/mL -1 mg/mL
S3988 Theophylline-7-acetic acid -1 mg/mL 47 mg/mL -1 mg/mL
S8105 ZM241385 <1 mg/mL 67 mg/mL <1 mg/mL
S8314 5-Iodotubercidin <1 mg/mL 78 mg/mL <1 mg/mL
S8104 SCH58261 <1 mg/mL 69 mg/mL <1 mg/mL
S7588 Reversine <1 mg/mL 5 mg/mL <1 mg/mL
Catalog No. Information Product Use Citations Product Validations


Istradefylline is a selective adenosine A2A receptor (A2AR) antagonist with Ki of 2.2 nM. Phase 3.


CGS 21680 HCl

CGS 21680 HCl is an adenosine A2 receptor agonist with IC50 of 22 nM, exhibits 140-fold over A1 receptor.



Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a β-N9-glycosidic bond.


A2AR antagonist 1

A2AR antagonist 1 is a potent A2AR (Adenosine A2A Receptor) antagonist with Ki values of 4 nM and 264 nM for A2AR and A1R, respectively.



Proxyphylline is a derivative of theophylline which is used as a bronchodilator and for its cardiovascular properties. It selectively antagonizes A1 adenosine receptors (Ki = 82 nM for bovine brain) versus A2 adenosine receptors (Ki = 850 µM for platelets).


AZD-4635 (HTL1071)

AZD-4635 (HTL1071) is an oral A2AR antagonist that binds to human A2AR with a Ki of 1.7 nM and with > 30-fold selectivity over other adenosine receptors.


Theophylline-7-acetic acid

Theophylline-7-acetic acid (Acefylline), acting as an adenosine receptor antagonist, is a stimulant drug of the xanthine chemical class.



ZM-241385 is a high affinity antagonist ligand selective for the adenosine A2A receptor.



5-Iodotubercidin is a potent adenosine kinase inhibitor with IC50 of 26 nM. It inhibits nucleoside transporter, CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC.



SCH 58261 is a potent and selective A2a adenosine receptor antagonist with Ki of 2.3 nM and 2 nM for rat A2a and bovine A2a, respectively.



Reversine is a potent human A3 adenosine receptor antagonist with Ki of 0.66 μM, and a pan-aurora A/B/C kinase inhibitor with IC50 of 12 nM/13 nM/20 nM, respectively. Also used for stem cell dedifferentiation.