Pim

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Pim Inhibitors (4)

water-soluble

Cat.No. Product Name Information Product Use Citation Customer Product Validation
S2198 SGI-1776 free base SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. Phase 1.
  • Oncogene, 2013, 32(34):3992-4000
  • Diabetologia., 2015, 58(9):2064-73
  • Oncotarget, 2011, 2(12):1134-44
S8005 SMI-4a SMI-4a is a potent inhibitor of Pim1 with IC50 of 17 nM, modestly potent to Pim-2, does not significantly inhibit any other serine/threonine- or tyrosine-kinases.
  • Blood, 2016, 10.1182/blood-2015-11-685032
S7104 AZD1208 AZD1208 is a potent, and orally available Pim kinase inhibitor with IC50 of 0.4 nM, 5 nM, and 1.9 nM for Pim1, Pim2, and Pim3 in cell-free assays, respectively. Phase 1.
  • Blood, 2016, 10.1182/blood-2015-11-685032
S7041 CX-6258 HCl CX-6258 HCl is a potent, orally efficacious pan-Pim kinase inhibitor with IC50 of 5 nM, 25 nM and 16 nM for Pim1, Pim2, and Pim3, respectively.

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Cat.No. Product Name Solubility (25°C)
Water DMSO Ethanol
S2198 SGI-1776 free base <1 mg/mL 81 mg/mL 81 mg/mL
S8005 SMI-4a <1 mg/mL 55 mg/mL 32 mg/mL
S7104 AZD1208 <1 mg/mL 75 mg/mL <1 mg/mL
S7041 CX-6258 HCl 89 mg/mL 57 mg/mL 1 mg/mL
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