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Cat.No. Product Name Information Product Use Citations Product Validations
S7174 Opaganib (ABC294640) Opaganib (ABC294640) is an orally bioavailable and selective sphingosine kinase-2 (SphK2) inhibitor with IC50 of approximately 60 μM. This compound is in Phase 1/2.
Sci Rep, 2025, 15(1):4152
Cell Res, 2022, 10.1038/s41422-022-00614-0
Bioact Mater, 2022, 15:29-43
Verified customer review of Opaganib (ABC294640)
S7177 PF-543 hydrochloride PF-543 hydrochloride, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM, exhibits >100-fold selectivity over the SphK2 isoform. This compound induces apoptosis, necrosis, and autophagy.
Cell Death Discov, 2025, 11(1):29
FASEB J, 2025, 39(12):e70768
FASEB J, 2025, 39(12):e70768
Verified customer review of PF-543 hydrochloride
S7176 SKI II SKI II (SphK-I2) is a highly selective and non ATP-competitive sphingosine kinase (SphK) inhibitor with IC50 of 0.5 μM, while this compound exhibits no inhibitory action on other kinases including PI3K, PKCα and ERK2.
Transl Cancer Res, 2025, 14(5):2594-2602
Clin Transl Med, 2022, 12(2):e695
Int J Biol Sci, 2022, 18(7):2994-3005
Verified customer review of SKI II
S0817 SKI-V SKI V is a noncompetitive and potent inhibitor of non-lipid sphingosine kinase with IC50 of 2 μM for GST-hSK. This compound also inhibits PI3K with IC50 of 6 μM for hPI3k. It decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P) and induces apoptosis with antitumor activity.
Cell Death Discov, 2022, 8(1):48
Cell Death Discov, 2022, 8(1):48
S6512 Defensamide (MHP) Defensamide (MHP) is an activator of sphingosine kinase (SPHK1) that modulates the innate epidermal immune response by potentiating SPHK1 activity and inducing cAMP production.
bioRxiv, 2025, 2024.08.06.606815
E1218 K6PC-5 K6PC-5, a ceramide derivative, is a sphingosine kinase 1 (SPHK1) activator and elicits a rapid transient increase in intracellular calcium levels.
Cell Prolif, 2024, e13604.
Int J Biol Sci, 2022, 18(7):2994-3005
S5989 SKI-178 SKI-178 is a potent inhibitors of sphingosine kinase-1 (SphK1) and SphK2 with IC50 values ranging from ∼500 nM to ∼1 μM depending on AML cell lines.